Dissecting early Skin-based immune responses to PARasites in ControLled human infection studies to design novel vaccines

Project Information

SPARCL

Grant agreement ID: 101075876

DOI

10.3030/101075876

EC signature date 21 December 2022

Start date 1 May 2023

End date 30 April 2028

Funded under

• European Research Council (ERC)

Total cost

€ 1 499 894,00

EU contribution

€ 1 499 894,00

Coordinated by

ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (7)

Clinical tolerance but no protective efficacy in a placebo-controlled trial of repeated controlled schistosome infection

Author(s): Koopman, Jan Pieter R.; Houlder, Emma L.; Janse, Jacqueline J.; Lamers, Olivia. A.C.; Roozen, Geert V.T.; Sijtsma, Jeroen C.; Casacuberta-Partal, Miriam; Hilt, Stan T.; van der Stoep, M.Y. Eileen C.; van Amerongen-Westra, Inge M.; Brienen, Eric A.T.; Wammes, Linda J.; van Lieshout, Lisette; van Dam, Govert J.; Corstjens, Paul L.A.M.; van Diepen, Angela; Yazdanbakhsh, Maria; Hokke, Cornelis H.; Roestenberg, Meta
Published in: Journal of Clinical Investigation, 2024, ISSN 1558-8238
Publisher: New York, N.Y. American Society for Clinical Investigation
DOI: 10.1172/JCI185422

Safety and Efficacy of Immunization with a Late-Liver-Stage Attenuated Malaria Parasite

Author(s): Olivia A.C. Lamers, Blandine M.D. Franke-Fayard, Jan Pieter R. Koopman, Geert V.T. Roozen, Jacqueline J. Janse, Severine C. Chevalley-Maurel, Fiona J.A. Geurten, Helena M. de Bes-Roeleveld, Eva Iliopoulou, Emil Colstrup, Els Wessels, Geert-Jan van Gemert, Marga van de Vegte-Bolmer, Wouter Graumans, Thabitha R. Stoter, Benjamin G. Mordmüller, Emma L. Houlder, Teun Bousema, Rajagopal Murugan, Matthew B.B. McCall, Chris J. Janse, Meta Roestenberg
Published in: New England Journal of Medicine, Issue 391, 2025, ISSN 0028-4793
Publisher: Massachusetts Medical Society
DOI: 10.1056/NEJMOA2313892

Trials

Author(s): Lamers, O.A.C.; Roestenberg, M.; Vries, M.C. de; Hoogerwerf, M.A.
Published in: Trials, 2024, ISSN 1745-6215
Publisher: BioMed Central
DOI: 10.1186/S13063-024-08582-Z

T cell responses in repeated controlled human schistosome infection compared to natural exposure

Author(s): Emmanuella Driciru; Jan Pieter R. Koopman; Sanne Steenbergen; Friederike Sonnet; Koen A. Stam; Helena de Bes-Roeleveld; Eva Iliopoulou; Jacqueline J. Janse; Jeroen Sijtsma; Irene Nambuya; Stan T. Hilt; Marion König; Yvonne Kruize; Miriam Casacuberta-Partal; Moses Egesa; Govert J. van Dam; Paul L.A.M. Corstjens; Lisette van Lieshout; Harriet Mpairwe; Andrew S. MacDonald; Maria Yazdanbakhsh; Alison M. Elliott; Meta Roestenberg; Emma L. Houlder
Published in: MedRXiv, 2025, ISSN 3067-2007
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2025.02.13.25322130

Correlative humoral and cellular immunity to genetically attenuated malaria parasites in humans

Author(s): Emil Colstrup, Rie Nakajima, Jelte M.M. Krol, Olivia A.C. Lamers, Rafael R. de Assis, Aarti Jain, Algis Jasinskas, Eva Iliopoulou, Helena M. de Bes-Roeleveld, Blandine M.D. Franke-Fayard, Meta Roestenberg, Philip L. Felgner, Rajagopal Murugan
Published in: iScience, Issue 28, 2025, ISSN 2589-0042
Publisher: Elsevier BV
DOI: 10.1016/J.ISCI.2025.112589

Early symptom-associated inflammatory responses shift to type 2 responses in controlled human schistosome infection

Author(s): Emma L. Houlder, Koen A. Stam, Jan Pieter R. Koopman, Marion H. König, Marijke C. C. Langenberg, Marie-Astrid Hoogerwerf, Paula Niewold, Friederike Sonnet, Jacqueline J. Janse, Miriam Casacuberta Partal, Jeroen C. Sijtsma, Laura H. M. de Bes-Roeleveld, Yvonne C. M. Kruize, Maria Yazdanbakhsh, Meta Roestenberg
Published in: Science Immunology, Issue 9, 2024, ISSN 2470-9468
Publisher: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/SCIIMMUNOL.ADL1965

Nature Medicine

Author(s): Geert V. T. Roozen; Roos van Schuijlenburg; Annefleur D. O. Hensen; Jan Pieter R. Koopman; Olivia A. C. Lamers; Fiona J. A. Geurten; Jeroen C. Sijtsma; Els Baalbergen; Jacqueline J. Janse; Séverine Chevalley-Maurel; Chanel M. Naar; Sascha Bezemer; Hans Kroeze; Huybert J. F. van de Stadt; Bram de Visser; Pauline Meij; Mara S. Tihaya; Emil Colstrup; Eva Iliopoulou; Helena M. de Bes-Roeleveld; Els Wessels; M. Y. Eileen C. van der Stoep; Chris J. Janse; Rajagopal Murugan; Blandine M. D. Franke-Fayard; Meta Roestenberg
Published in: Nature Medicine, 2025, ISSN 1078-8956
Publisher: New York, NY Nature Pub. Co.
DOI: 10.1038/S41591-024-03347-2