The molecular nexus coupling Cell Metabolism to Cell cycle and Genome Surveillance

Project Information

META-SURVEILLANCE

Grant agreement ID: 101077859

DOI

10.3030/101077859

EC signature date 23 March 2023

Start date 1 October 2023

End date 30 September 2028

Funded under

• European Research Council (ERC)

Total cost

€ 1 499 329,00

EU contribution

€ 1 499 329,00

Coordinated by

SYDDANSK UNIVERSITET
Denmark

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (6)

CDK12/CDK13 inhibition disrupts transcriptional elongation and replication fork progression in glioblastoma

Author(s): Silje Lier, Sara B Markusson, Anja Kocijancic, Martine Narum, Solveig O Lund, Bianka Böllering, Anuja Lipsa, Mirra L C Søegaard, Idun D Rein, Petra Santha, Preeti Jain, Anna Lång, Emma Lång, Niklas Meyer, Aparajita Dutta, Santosh Anand, Sugith B Badugu, Gaute J Nesse, Rune J Forstrøm, Arne Klungland, Ashish Anand, Steven M Pollard, Stig O Bøe, Johanne E Rinholm, Katrin B M Frauenknecht, Anna Golebiewska, Simone P Niclou, Kumar Somyajit, Mads Lerdrup, Deo P Pandey
Published in: EMBO Molecular Medicine, Issue 18, 2026, ISSN 1757-4684
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S44321-026-00393-W

RAD51C-XRCC3 complex regulates FANCM-mediated R-loop resolution to safeguard genome integrity

Author(s): Satyaranjan Sahoo, Tarun Nagraj, Debanjali Bhattacharya, Nupur Nagar, Kumar Somyajit, Krishna Mohan Poluri, Ganesh Nagaraju
Published in: Science Advances, Issue 12, 2026, ISSN 2375-2548
Publisher: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/SCIADV.AEA5932

RTEL1 helicase counteracts RAD51-mediated homologous recombination and fork reversal to safeguard replicating genomes

Author(s): Suruchi Dixit, Tarun Nagraj, Debanjali Bhattacharya, Sneha Saxena, Satyaranjan Sahoo, Rajani Kant Chittela, Kumar Somyajit, Ganesh Nagaraju
Published in: Cell Reports, Issue 43, 2025, ISSN 2211-1247
Publisher: Elsevier BV
DOI: 10.1016/J.CELREP.2024.114594

Oncohistone-sculpted epigenetic mechanisms in pediatric brain cancer

Author(s): Deo Prakash Pandey, Kumar Somyajit
Published in: Current Opinion in Pharmacology, Issue 81, 2025, ISSN 1471-4892
Publisher: Elsevier BV
DOI: 10.1016/J.COPH.2025.102505

Metabolic control of replisome plasticity in genome surveillance

Author(s): Mikkel Bo Petersen, Gita Chhetri, Kumar Somyajit
Published in: Trends in Cell Biology, Issue 35, 2025, ISSN 0962-8924
Publisher: Elsevier BV
DOI: 10.1016/J.TCB.2025.01.006

PAF15–PCNA exhaustion governs the strand-specific control of DNA replication

Author(s): Gita Chhetri, Sugith Babu Badugu, Narcis-Adrian Petriman, Mikkel Bo Petersen, Aylin Seren Güller, Nora Fajri, Manon Coulée, Ganesha Pandian Pitchai, Jan Novotný, Frederik Tibert Larsen, Andreas Fønss Møller, Morten Frendø Ebbesen, Tina Ravnsborg, Anoop Kumar Yadav, Barath Balarasa, Anita Lunding, Hana Polasek-Sedlackova, Ole N. Jensen, Kim Ravnskjaer, Jonathan R. Brewer, Jesper Grud Skat Madsen, Nataliya Petryk, Jens S. Andersen, Kumar Somyajit
Published in: Nature, Issue 651, 2026, ISSN 0028-0836
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41586-025-10011-3