Immune-stromal crosstalk in inflammation and fibrosis: Exploiting the spatiotemporal dynamics of the OSM-OSMR axis in inflammatory bowel disease to develop novel antifibrotic therapies

Project Information

iMOTIONS

Grant agreement ID: 101078069

DOI

10.3030/101078069

EC signature date 1 February 2023

Start date 1 September 2023

End date 31 August 2028

Funded under

• European Research Council (ERC)

Total cost

€ 1 499 816,00

EU contribution

€ 1 499 816,00

Coordinated by

CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (7)

The IL-22–oncostatin M axis promotes intestinal inflammation and tumorigenesis

Author(s): Roodline Cineus; Yanjiang Luo; Mariia Saliutina; Subhakankha Manna; Camila A. Cancino; Luis Velasco Blázquez; Lifen Wang; Diana Bösel; Aya Abdelrahman; Joanna E. Klementowicz; Alexis Scherl; Saskia Hainbuch; Béatrice Bréart; Gino Kwon; Agata Konopka; Gabriela M. Guerra; Elena von Coburg; Lorenz Gerbeth; Juliette Roels; Frederik Heinrich; Nils Müller; Pawel Durek; Nikolaus Deigendesch; James Ziai; Jeffrey Hung; Thomas Conrad; Imke Atreya; Raja Atreya; Petra Bacher; Christoph Becker; Christian Bojarski; Nathalie Britzen-Laurent; Caroline Bosch-Voskens; Hyun-Dong Chang; Andreas Diefenbach; Claudia Günther; Ahmed N. Hegazy; Kai Hildner; Christoph S. N. Klose; Kristina Koop; Susanne Krug; Moritz Leppkes; Rocío López-Posadas; Leif S.-H. Ludwig; Clemens Neufert; Markus Neurath; Jay Patankar; Magdalena Prüß; Andreas Radbruch; Francesca Ronchi; Ashley Sanders; Alexander Scheffold; Jörg-Dieter Schulzke; Sebastian Schürmann; Michael Stürzl; Zlatko Trajanoski; Antigoni Triantafyllopoulou; Maximilian Waldner; Carl Weidinger; Sebastian Zundler; Anja A. Kühl; Stefan Wirtz; Max Löhning; Mary Keir; Andreas Diefenbach; Mir-Farzin Mashreghi; Britta Siegmund; Michael Schumann; Chiara Romagnani; Nathaniel R. West; Ahmed N. Hegazy
Published in: Nature Immunology, 2025, ISSN 1529-2916
Publisher: Springer Nature
DOI: 10.1038/S41590-025-02149-Z

Gastroenterology

Author(s): Veronika Horn; Camila A. Cancino; Lisa M. Steinheuer; Benedikt Obermayer; Konstantin Fritz; Anke L. Nguyen; Kim Susan Juhran; Christina Plattner; Diana Bösel; Lotte Oldenburg; Marie Burns; Axel Ronald Schulz; Mariia Saliutina; Eleni Mantzivi; Donata Lissner; Thomas Conrad; Mir-Farzin Mashreghi; Sebastian Zundler; Elena Sonnenberg; Michael Schumann; Lea-Maxie Haag; Dieter Beule; Lukas Flatz; Imke Atreya; Raja Atreya; Petra Bacher; Christoph Becker; Christian Bojarski; Nathalie Britzen-Laurent; Caroline Bosch-Voskens; Hyun-Dong Chang; Andreas Diefenbach; Claudia Günther; Ahmed N. Hegazy; Kai Hildner; Christoph S.N. Klose; Kristina Koop; Susanne Krug; Anja A. Kühl; Moritz Leppkes; Rocío López-Posadas; Leif S-H. Ludwig; Clemens Neufert; Markus Neurath; Jay Patankar; Magdalena Prüß; Andreas Radbruch; Chiara Romagnani; Francesca Ronchi; Ashley Sanders; Alexander Scheffold; Jörg-Dieter Schulzke; Michael Schumann; Sebastian Schürmann; Britta Siegmund; Michael Stürzl; Zlatko Trajanoski; Antigoni Triantafyllopoulou; Maximilian Waldner; Carl Weidinger; Stefan Wirtz; Sebastian Zundler; Zlatko Trajanoski; Geert D’Haens; Carl Weidinger; Henrik E. Mei; Britta Siegmund; Kevin Thurley; Ahmed N. Hegazy
Published in: Gastroenterology, 2025, ISSN 0016-5085
Publisher: American Gastroenterological Association
DOI: 10.1053/J.GASTRO.2024.09.021

Nature Methods

Author(s): Dominik Vonficht; Lea Jopp-Saile; Schayan Yousefian; Viktoria Flore; Inés Simó Vesperinas; Ruth Teuber; Bogdan Avanesyan; Yanjiang Luo; Caroline Röthemeier; Florian Grünschläger; Mirian Fernandez-Vaquero; Vincent Fregona; Diana Ordoñez-Rueda; Laura K. Schmalbrock; Luca Deininger; Angelo Jovin Yamachui Sitcheu; Zuguang Gu; Maja C. Funk; Ralf Mikut; Mathias Heikenwälder; Angelika Eggert; Arend von Stackelberg; Sebastian Kobold; Jan Krönke; Ulrich Keller; Andreas Trumpp; Ahmed N. Hegazy; Cornelia Eckert; Daniel Hübschmann; Simon Haas
Published in: Nature Methods, 2025, ISSN 1548-7091
Publisher: Springer Nature
DOI: 10.5445/IR/1000183893

Scientific Reports

Author(s): Reyes Gámez-Belmonte; Yara Wagner; Mousumi Mahapatro; Ru Wang; Lena Erkert; Miguel González-Acera; Roodline Cineus; Saskia Hainbuch; Jay V. Patankar; David Voehringer; Ahmed N. Hegazy; Markus F. Neurath; Stefan Wirtz; Christoph Becker
Published in: Scientific Reports, 2024, ISSN 2045-2322
Publisher: Springer Nature
DOI: 10.1038/S41598-024-78336-Z

Mucosal Immunology

Author(s): Lena Erkert; Barbara Ruder; Melanie Kabisch; Reyes Gamez Belmonte; Jay V. Patankar; Miguel Gonzalez Acera; Lena Schödel; Mircea T. Chiriac; Roodline Cineus; Stylianos Gnafakis; Tamara Leupold; Oana-Maria Thoma; Iris Stolzer; Astrid Taut; Veronika Thonn; Sebastian Zundler; Claudia Günther; Andreas Diefenbach; Anja A. Kühl; Ahmed N. Hegazy; Maximilian Waldner; Marijana Basic; André Bleich; Markus F. Neurath; Stefan Wirtz; Christoph Becker; Imke Atreya; Raja Atreya; Petra Bacher; Christoph Becker; Christian Bojarski; Nathalie Britzen-Laurent; Caroline Bosch-Voskens; Hyun-Dong Chang; Andreas Diefenbach; Claudia Günther; Ahmed N. Hegazy; Kai Hildner; Christoph S.N. Klose; Kristina Koop; Susanne Krug; Anja A. Kühl; Moritz Leppkes; Rocío López-Posadas; Leif S.-H. Ludwig; Clemens Neufert; Markus Neurath; Jay V. Patankar; Christina Plattner; Magdalena Prüß; Andreas Radbruch; Chiara Romagnani; Francesca Ronchi; Ashley Sanders; Alexander Scheffold; Jörg-Dieter Schulzke; Michael Schumann; Sebastian Schürmann; Britta Siegmund; Michael Stürzl; Zlatko Trajanoski; Antigoni Triantafyllopoulou; Maximilian Waldner; Carl Weidinger; Stefan Wirtz; Sebastian Zundler
Published in: Mucosal Immunology, 2025, ISSN 1933-0219
Publisher: Springer Nature
DOI: 10.1016/J.MUCIMM.2025.01.003

Gut

Author(s): Miguel Gonzalez-Acera; Jay V Patankar; Lena Erkert; Roodline Cineus; Reyes Gamez-Belmonte; Tamara Leupold; Marvin Bubeck; Li-Li Bao; Martin Dinkel; Ru Wang; Laura Schickedanz; Heidi Limberger; Iris Stolzer; Katharina Gerlach; Leonard Diemand; Fabrizio Mascia; Pooja Gupta; Elisabeth Naschberger; Kristina Koop; Christina Plattner; Gregor Sturm; Benno Weigmann; Claudia Günther; Stefan Wirtz; Michael Stürzl; Kai Hildner; Anja A Kühl; Britta Siegmund; Andreas Gießl; Raja Atreya; Ahmed N Hegazy; Zlatko Trajanoski; Markus F Neurath; Christoph Becker
Published in: Gut, 2025, ISSN 0017-5749
Publisher: British Society of Gastroenterology
DOI: 10.1136/GUTJNL-2024-333729

A transcriptional atlas of gut-innervating neurons reveals activation of interferon signaling and ferroptosis during intestinal inflammation

Author(s): Patrycja M. Forster; Manuel O. Jakob; Dilmurat Yusuf; Marvin Bubeck; Heidi Limberger; Yanjiang Luo; Paula Thieme; Alexandra Polici; Nele Sterczyk; Sotiria Boulekou; Laura Bartel; Catalina Cosovanu; Mario Witkowski; Miguel González-Acera; Anja A. Kühl; Carl Weidinger; Imke Atreya; Raja Atreya; Petra Bacher; Christoph Becker; Christian Bojarski; Nathalie Britzen-Laurent; Caroline Bosch-Voskens; Hyun-Dong Chang; Andreas Diefenbach; Claudia Günther; Ahmed N. Hegazy; Kai Hildner; Christoph S.N. Klose; Kristina Koop; Susanne Krug; Anja A. Kühl; Moritz Leppkes; Rocío López-Posadas; Leif S.-H. Ludwig; Clemens Neufert; Markus Neurath; Jay V. Patankar; Magdalena Prüß; Andreas Radbruch; Chiara Romagnani; Francesca Ronchi; Ashley Sanders; Alexander Scheffold; Jörg-Dieter Schulzke; Michael Schumann; Sebastian Schürmann; Britta Siegmund; Michael Stürzl; Zlatko Trajanoski; Antigoni Triantafyllopoulou; Maximilian Waldner; Carl Weidinger; Stefan Wirtz; Sebastian Zundler; Rolf Backofen; Ahmed N. Hegazy; Jay V. Patankar; Christoph S.N. Klose
Published in: Neuron, 2025, ISSN 1097-4199
Publisher: Cell Press
DOI: 10.48620/86870