Project description DEENESFRITPL Effects of supramaximal high-intensity training on brain, muscle and heart health The mortality rate in chronic obstructive pulmonary disease (COPD) patients is often attributed to extrapulmonary manifestations. New treatment modalities beyond the lungs are needed. The EU-funded COPD-HIT project will improve our understanding of the development and treatment of extrapulmonary manifestations in COPD. It will focus on brain health, muscle quality and cardiac function. The project will conduct multicentre randomised controlled and experimental trials to assess the impact of supramaximal high-intensity training on the brain, muscles and heart. It will also study the relationship between exercise and inflammation and their effect on neurodegeneration. COPD HIT will also develop an in vitro model to analyse the signalling pathways activated by different levels of loading intensities. Show the project objective Hide the project objective Objective Given the substantial negative impact of extrapulmonary manifestations on vital clinical outcomes, including mortality, the need for new effective treatment modalities also beyond the lungs has been highlighted as an urgent challenge in the management of chronic obstructive pulmonary disease (COPD), one of the most common and deadliest diseases of the 21st century. The aim of COPD-HIT is to pave the way for new understanding of the development and treatment of extrapulmonary manifestations in COPD with a focus on brain health, muscle quality, and cardiac function. To do this I will focus on the following research objectives (RO):● RO1) Determine the effect of supramaximal High-Intensity Training (HIT) on the brain, muscle, and heart● RO2) Determine how exercise training and inflammation impacts the trajectories of neurodegeneration● RO3) Develop a novel in-vitro model to determine signaling pathways following various loading intensitiesTo reach these objectives, I aim to conduct high-quality multicenter randomized controlled and experimental trials. Further, I will lead an international research alliance with access to state-of-the-art research infrastructures and enable a unique interdisciplinary approach to fulfill my goals. This includes using advanced measurement techniques for muscle, brain, and cardiorespiratory evaluations, muscle biopsy analyses, in-vivo & in-vitro strategies, and combining quantitative and qualitative methods. Taken together, with COPD-HIT, I am in a strong position to perform an international novel project that will determine how to enable extrapulmonary benefits in COPD in a hitherto unprecedented way. Fields of science natural sciencesbiological sciencesneurobiologysocial sciencessociologydemographymortality Keywords high-intensity interval training COPD skeletal muscle cognitive dysfunction limb muscle dysfunction Programme(s) HORIZON.1.1 - European Research Council (ERC) Main Programme Topic(s) ERC-2022-STG - ERC STARTING GRANTS Call for proposal ERC-2022-STG See other projects for this call Funding Scheme ERC - Support for frontier research (ERC) Coordinator UMEA UNIVERSITET Net EU contribution € 1 490 438,00 Address Universitetomradet 901 87 Umea Sweden See on map Region Norra Sverige Övre Norrland Västerbottens län Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00
