Project description
Effects of supramaximal high-intensity training on brain, muscle and heart health
The mortality rate in chronic obstructive pulmonary disease (COPD) patients is often attributed to extrapulmonary manifestations. New treatment modalities beyond the lungs are needed. The EU-funded COPD-HIT project will improve our understanding of the development and treatment of extrapulmonary manifestations in COPD. It will focus on brain health, muscle quality and cardiac function. The project will conduct multicentre randomised controlled and experimental trials to assess the impact of supramaximal high-intensity training on the brain, muscles and heart. It will also study the relationship between exercise and inflammation and their effect on neurodegeneration. COPD HIT will also develop an in vitro model to analyse the signalling pathways activated by different levels of loading intensities.
Objective
Given the substantial negative impact of extrapulmonary manifestations on vital clinical outcomes, including mortality, the need for new effective treatment modalities also beyond the lungs has been highlighted as an urgent challenge in the management of chronic obstructive pulmonary disease (COPD), one of the most common and deadliest diseases of the 21st century.
The aim of COPD-HIT is to pave the way for new understanding of the development and treatment of extrapulmonary manifestations in COPD with a focus on brain health, muscle quality, and cardiac function.
To do this I will focus on the following research objectives (RO):
RO1) Determine the effect of supramaximal High-Intensity Training (HIT) on the brain, muscle, and heart
RO2) Determine how exercise training and inflammation impacts the trajectories of neurodegeneration
RO3) Develop a novel in-vitro model to determine signaling pathways following various loading intensities
To reach these objectives, I aim to conduct high-quality multicenter randomized controlled and experimental trials. Further, I will lead an international research alliance with access to state-of-the-art research infrastructures and enable a unique interdisciplinary approach to fulfill my goals. This includes using advanced measurement techniques for muscle, brain, and cardiorespiratory evaluations, muscle biopsy analyses, in-vivo & in-vitro strategies, and combining quantitative and qualitative methods.
Taken together, with COPD-HIT, I am in a strong position to perform an international novel project that will determine how to enable extrapulmonary benefits in COPD in a hitherto unprecedented way.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2022-STG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
901 87 UMEA
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.