Boosting the One Health Research Excellence and Management Capacity of the Estonian University of Life Sciences

Información del proyecto

OH-Boost

Identificador del acuerdo de subvención: 101079349

DOI

10.3030/101079349

Proyecto cerrado

Fecha de la firma de la CE 11 Julio 2022

Fecha de inicio 1 Enero 2023

Fecha de finalización 31 Diciembre 2025

Financiado con arreglo a

• Widening participation and spreading excellence

Coste total

€ 1 499 375,00

Aportación de la UE

€ 1 499 375,00

Coordinado por

EESTI MAAULIKOOL
Estonia

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Data Management Plan (1)

Data management plan

DMP following HEU data management guidelines.

Documents, reports (2)

Online presence established

Including project website, partner websites, social media accounts.

CDE plan

A communication, dissemination and exploitation (CDE) plan guiding WP5 activities.

Publicaciones

Peer reviewed articles (40)

Scientific Reports

Autores: Muhandiram, Subhashini; Kodithuwakku, Suranga; Godakumara, Kasun; Fazeli, Alireza
Publicado en: Scientific Reports, 2024, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/S41598-024-75893-1

Rhythm of the First Language: Dynamics of Extracellular Vesicle-Based Embryo–Maternal Communication in the Pre-Implantation Microenvironment, OH-Boost project related publication, M1 to M16

Autores: Kasun Godakumara, Paul R. Heath and Alireza Fazeli
Publicado en: International Journal of Molecular Sciences (2003), 2023, ISSN 1422-0067
Editor: MDPI
DOI: 10.3390/ijms24076811

Generation of Porcine and Rainbow Trout 3D Intestinal Models and Their Use to Investigate Astaxanthin Effects In Vitro.

Autores: Arcuri, Sharon; PENNAROSSA, GEORGIA; Prasadani, Madhusha; Pasquariello, Rolando; Gandolfi, Fulvio; Brevini, Tiziana A.L.
Publicado en: International Journal of Molecular Sciences, 2024, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/IJMS25115966

Uterine Fluid Extracellular Vesicles Proteome Is Altered During the Estrous Cycle, OH-Boost project related publication, M1 to M16

Autores: Johanna Piibor, Andres Waldmann, Keerthie Dissanayake, Aneta Andronowska, Marilin Ivask, Madhusha Prasadani, Ants Kavak, Suranga Kodithuwakku, and Alireza Fazeli
Publicado en: Molecular and cellular proteomics (2023), 2023, ISSN 1535-9476
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.mcpro.2023.100642

Effects of Bovine Milk-Derived Extracellular Vesicles on a 3D Intestinal Stromal Compartment

Autores: Georgia Pennarossa; Sharon Arcuri; Madhusha Prasadani; Fulvio Gandolfi; Alireza Fazeli; Tiziana A. L. Brevini
Publicado en: Cells, 2026, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/CELLS15030242

Secretory Proteomic Responses of Endometrial Epithelial Cells to Trophoblast-Derived Extracellular Vesicles,OH-Boost project related publication, M1 to M16

Autores: Subhashini Muhandiram, Keerthie Dissanayake, Toomos Orro, Kasun Godakumara, Suranga Kodithuwakku and Alireza Fazeli
Publicado en: International Journal of Molecular Sciences (2023), 2023, ISSN 1422-0067
Editor: MDPI
DOI: 10.3390/ijms241511924

Rapid increase of MFGE8 secretion from endometrial epithelial cells is an indicator of extracellular vesicle mediated embryo maternal dialogue

Autores: Muhandiram, Subhashini; Kodithuwakku, Suranga; Godakumara, Kasun; Fazeli, Alireza
Publicado en: Scientific Reports, 2024, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/S41598-024-75893-1

Journal of Dairy Science

Autores: Premathilaka, Chanaka; Kodithuwakku, Suranga; Midekessa, Getnet; Godakumara, Kasun; Ul Ain Reshi, Qurat; Andronowska, Aneta; Orro, Toomas; Fazeli, Alireza
Publicado en: Bovine fecal extracellular vesicles: A novel noninvasive tool for understanding gut physiology and pathophysiology in calves, 2025, ISSN 0022-0302
Editor: American Dairy Science Association
DOI: 10.3168/JDS.2024-25920

Reproduction in Domestic Animals

Autores: Fazeli, Alireza; Godakumara, Kasun; Kodithuwakku, Suranga; Muhandiram, Subhashini
Publicado en: Reproduction in Domestic Animals, 2025, ISSN 0936-6768
Editor: Wiley
DOI: 10.1111/RDA.70112

Uptake of Ascaridia galli extracellular vesicles by chicken immune cells varies according to worm sex and in vitro culture duration

Autores: Anna Sophia Feix; Konstantinos Papanikolaou; Rikke Brødsgaard Kjærup; Chanaka Premathilaka; Suranga Kodithuwakku; Alireza Fazeli; Anders Miki Bojesen; Carolina Corral Yélamos; Tina Sørensen Dalgaard
Publicado en: International Journal for Parasitology, 2025, ISSN 0020-7519
Editor: Elsevier BV
DOI: 10.1016/J.IJPARA.2025.104765

Effect of 3D and 2D cell culture systems on trophoblast extracellular vesicle physico-chemical characteristics and potency

Autores: Norhayati Liaqat Ali Khan; Norhayati Liaqat Ali Khan; Subhashini Muhandiram; Keerthie Dissanayake; Keerthie Dissanayake; Kasun Godakumara; Kasun Godakumara; Getnet Midekessa; Getnet Midekessa; Aneta Andronowska; Paul R. Heath; Suranga Kodithuwakku; Suranga Kodithuwakku; Amber Rose Hart; Alireza Fazeli; Alireza Fazeli; Alireza Fazeli
Publicado en: Frontiers in Cell and Developmental Biology, 2024, ISSN 2296-634X
Editor: Frontiers
DOI: 10.3389/FCELL.2024.1382552

Investigation of Uterine Fluid Extracellular Vesicles’ Proteomic Profiles Provides Novel Diagnostic Biomarkers of Bovine Endometritis

Autores: Piibor, Johanna; Waldmann, Andres; Prasadani, Madhusha; Kavak, Ants; ANDRONOWSKA, Aneta; Klein, Claudia; Kodithuwakku, Suranga; Fazeli, Alireza
Publicado en: Biomolecules, 2024, ISSN 2218-273X
Editor: MDPI
DOI: 10.3390/BIOM14060626

Cryptosporidium spp. infection drives distinct alterations in the faecal extracellular vesicles metaproteome of calves

Autores: Chanaka Premathilaka, Kasun Godakumara, Mandy Jayne Peffers, Emily J. Clarke, Elisabeth Dorbek-Sundström, Toomas Orro, Suranga Kodithuwakku, Alireza Fazeli
Publicado en: Journal of Animal Science and Biotechnology, Edición 17, 2026, ISSN 2049-1891
Editor: Springer Science and Business Media LLC
DOI: 10.1186/S40104-025-01332-4

Cruciferous vegetable-derived indole-3-carbinol prevents coronavirus cell egression mechanisms in tracheal and intestinal 3D in vitro models

Autores: Pennarossa, Georgia; Arcuri, Sharon; Pasquariello, Rolando; Gandolfi, Fulvio; Maranesi, Margherita; Brevini, Tiziana
Publicado en: Phytochemistry, 2023, ISSN 0308-8146
Editor: Elsevier BV
DOI: 10.1016/J.PHYTOCHEM.2023.113713

Bovine Faecal Extracellular Vesicles: A novel non-invasive tool for understanding gut physiology and pathophysiology in calves

Autores: Premathilaka, Chanaka; Kodithuwakku, Suranga; Midekessa, Getnet; Godakumara, Kasun; Ul Ain Reshi, Qurat; Andronowska, Aneta; Orro, Toomas; Fazeli, Alireza
Publicado en: Journal of Dairy Science, 2025, ISSN 0022-0302
Editor: American Dairy Science Association
DOI: 10.3168/JDS.2024-25920

Extracellular Vesicles in Reproduction: Biology, Production, and Potential Applications in Livestock Breeding

Autores: Fazeli, Alireza; Godakumara, Kasun; Kodithuwakku, Suranga; Muhandiram, Subhashini
Publicado en: Reproduction in Domestic Animals, 2025, ISSN 0936-6768
Editor: Blackwell Publishing Inc.
DOI: 10.1111/RDA.70112

Bioengineering-tissue strategies to model mammalian implantation in vitro

Autores: Pennarossa, Georgia; Arcuri, Sharon; Zmijewska, Agata; Orini, Elena; Gandolfi, Fulvio; Brevini, Tiziana
Publicado en: Frontiers in Bioengineering and Biotechnology, 2024, ISSN 2296-4185
Editor: Frontiers
DOI: 10.3389/FBIOE.2024.1430235

Does extracellular vesicle specificity truly exist?

Autores: Muhandiram, Subhashini;Fazeli, Alireza
Publicado en: Cell Communication and Signaling, 2026, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1186/S12964-026-02654-0

SARS-CoV-2 clade dynamics and their associations with hospitalisations during the first two years of the COVID-19 pandemic

Autores: Soeorg, Hiie; Abroi, Aare; Päll, Taavi; Dotsenko, Liidia; Jaaniso, Erik; Kaarna, Katrin; Lahesaare, Andrio; Naaber, Paul; Niglas, Heiki; Oopkaup, Ott Eric; Peterson, Hedi; Reisberg, Tuuli; Sadikova, Olga; Smit, Steven; Talas, Ulvi Gerst; Avi, Radko; Lutsa
Publicado en: PLOS ONE, 2024, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/JOURNAL.PONE.0303176

Food Chemistry

Autores: Pennarossa, Georgia; Arcuri, Sharon; Pasquariello, Rolando; Gandolfi, Fulvio; Maranesi, Margherita; Brevini, Tiziana
Publicado en: Phytochemistry, 2023, ISSN 0308-8146
Editor: Elsevier BV
DOI: 10.1016/J.PHYTOCHEM.2023.113713

Harnessing Nature’s Defence: The Antimicrobial Efficacy of Pasteurised Cattle Milk-Derived Extracellular Vesicles on Staphylococcus aureus ATCC 25923, OH-Boost project related publication, M1 to M16

Autores: Dulmini Nanayakkara Sapugahawatte, Kasun Godakumara, Mihkel Mäesaar, Gayandi Ekanayake, Getnet Balcha Midekessa, Madhusha Prasadani, Suranga Kodithuwakku, Mati Roasto, Aneta Andronowska andAlireza Fazeli
Publicado en: International Journal of Molecular Sciences (2024 April), 2024, ISSN 1422-0067
Editor: MDPI
DOI: 10.3390/ijms25094759

Therapeutic Potential of Bovine Milk-Derived Extracellular Vesicles.

Autores: Prasadani, Madhusha; Kodithuwakku, Suranga; PENNAROSSA, GEORGIA; Fazeli, Alireza; Brevini, Tiziana A.L.
Publicado en: International Journal of Molecular Sciences, 2024, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/IJMS25105543

International Journal of Molecular Sciences

Autores: Arcuri, Sharon; PENNAROSSA, GEORGIA; Prasadani, Madhusha; Pasquariello, Rolando; Gandolfi, Fulvio; Brevini, Tiziana A.L.
Publicado en: International Journal of Molecular Sciences, 2024, ISSN 1422-0067
Editor: MDPI
DOI: 10.3390/IJMS25115966

The evolving roles of extracellular vesicles in embryo-maternal communication

Autores: Godakumara, Kasun; Fazeli, Alireza
Publicado en: Communications Biology, 2024, ISSN 2399-3642
Editor: Spring Nature
DOI: 10.1038/S42003-024-06442-9

Combination of epigenetic erasing and mechanical cues to generate human epiBlastoids from adult dermal fibroblasts

Autores: Pennarossa, Georgia; Arcuri, Sharon; De Iorio, Teresina; Ledda, Sergio; Gandolfi, Fulvio; Brevini, Tiziana
Publicado en: Journal of Assisted Reproduction and Genetics, 2023, ISSN 1058-0468
Editor: Kluwer Academic/Plenum Publishers
DOI: 10.1007/S10815-023-02773-4

Dynamics of SARS-CoV-2 lineages in children and adults in 2021 and 2022

Autores: Hiie Soeorg, Aare Abroi, Taavi Päll, Liidia Dotsenko, Erik Jaaniso, Katrin Kaarna, Andrio Lahesaare, Paul Naaber, Heiki Niglas, Ott Eric Oopkaup, Hedi Peterson, Tuuli Reisberg, Olga Sadikova, Steven Smit, Ulvi Gerst Talas, Radko Avi, Irja Lutsar, Kristi Huik
Publicado en: PLOS ONE, Edición 19, 2024, ISSN 1932-6203
Editor: Public Library of Science (PLoS)
DOI: 10.1371/JOURNAL.PONE.0316213

Extracellular vesicles as mediators of stress response in embryo-maternal communication

Autores: Seyed Omid Mousavi; Qurat Ul Ain Reshi; Qurat Ul Ain Reshi; Kasun Godakumara; Suranga Kodithuwakku; Suranga Kodithuwakku; Alireza Fazeli; Alireza Fazeli; Alireza Fazeli
Publicado en: Frontiers in Cell and Developmental Biology, 2024, ISSN 2296-634X
Editor: Frontiers
DOI: 10.3389/FCELL.2024.1440849

Frontiers in Plant Science

Autores: Gayandi Ekanayake; Johanna Piibor; Getnet Midekessa; Getnet Midekessa; Kasun Godakumara; Keerthie Dissanayake; Keerthie Dissanayake; Aneta Andronowska; Rajeev Bhat; Alireza Fazeli; Alireza Fazeli; Alireza Fazeli
Publicado en: Frontiers in Plant Science, 2024, ISSN 1664-462X
Editor: Frontiers Media S. A.
DOI: 10.3389/FPLS.2024.1477614

Immunomodulatory effects of Ascaridia galli excretory-secretory products,including extracellular vesicles, on host immune cell function

Autores: Premathilaka, Chanaka; Feix, Anna Sophia; Papanikolaou, Konstantinos; Kjærup, Rikke Brødsgaard; ANDRONOWSKA, Aneta; Kodithuwakku, Suranga; Fazeli, Alireza; Dalgaard, Tina
Publicado en: Avian Pathology, 2025, ISSN 1465-3338
Editor: Taylor & Francis
DOI: 10.1080/03079457.2025.2528838

Generation of Artificial Blastoids Combining miR-200-Mediated Reprogramming and Mechanical Cues

Autores: Georgia Pennarossa; Sharon Arcuri; Fulvio Gandolfi; Tiziana Brevini
Publicado en: Cells, 2024, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/CELLS13070628

Milk-Derived Extracellular Vesicles Protect Bovine Oviduct Epithelial Cells from Oxidative Stress

Autores: Seyed Omid Reza Mousavi, Qurat Ul Ain Reshi, Kasun Godakumara, Subhashini Muhandiram, Getnet Midekessa, Aneta Andronowska, Sergei Kopanchuk, Darja Lavogina, Ago Rinken, Suranga Kodithuwakku, Alireza Fazeli
Publicado en: Cells, Edición 15, 2025, ISSN 2073-4409
Editor: MDPI AG
DOI: 10.3390/CELLS15010018

Systematic characterization of extracellular vesicles from potato (Solanum tuberosum cv. Laura) roots and peels: biophysical properties and proteomic profiling

Autores: Gayandi Ekanayake; Johanna Piibor; Getnet Midekessa; Getnet Midekessa; Kasun Godakumara; Keerthie Dissanayake; Keerthie Dissanayake; Aneta Andronowska; Rajeev Bhat; Alireza Fazeli; Alireza Fazeli; Alireza Fazeli
Publicado en: Frontiers in Plant Science, 2024, ISSN 1664-462X
Editor: Frontiers Media S. A.
DOI: 10.3389/FPLS.2024.1477614

Immunomodulatory effects of <i>Ascaridia galli</i> excretory-secretory products, including extracellular vesicles, on host immune cell function

Autores: Premathilaka, Chanaka; Feix, Anna Sophia; Papanikolaou, Konstantinos; Kjærup, Rikke Brødsgaard; ANDRONOWSKA, Aneta; Kodithuwakku, Suranga; Fazeli, Alireza; Dalgaard, Tina
Publicado en: Avian Pathology, 2025, ISSN 1465-3338
Editor: Taylor & Francis
DOI: 10.1080/03079457.2025.2528838

Detection of Organelle-Specific Dyes Labeled Extracellular Vesicles with Colocalization-Fluorescence Nanoparticle Tracking Analysis

Autores: Midekessa, Getnet; Godakumara, Kasun; Hasan, Mohammad Mehedi; Andronowska, Aneta; Fazeli, Alireza
Publicado en: ACS Omega, 2026, ISSN 2470-1343
Editor: ACS
DOI: 10.1021/ACSOMEGA.5C12069

Journal of Assisted Reproduction and Genetics

Autores: Pennarossa, Georgia; Arcuri, Sharon; De Iorio, Teresina; Ledda, Sergio; Gandolfi, Fulvio; Brevini, Tiziana
Publicado en: Journal of Assisted Reproduction and Genetics, 2023, ISSN 1058-0468
Editor: Kluwer Academic/Plenum Publishers
DOI: 10.1007/S10815-023-02773-4

PLoS ONE

Autores: Soeorg, Hiie; Abroi, Aare; Päll, Taavi; Dotsenko, Liidia; Jaaniso, Erik; Kaarna, Katrin; Lahesaare, Andrio; Naaber, Paul; Niglas, Heiki; Oopkaup, Ott Eric; Peterson, Hedi; Reisberg, Tuuli; Sadikova, Olga; Smit, Steven; Talas, Ulvi Gerst; Avi, Radko; Lutsar, Irja; Huik, Kristi
Publicado en: PLOS ONE, 2024, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/JOURNAL.PONE.0316213

Do extracellular vesicles have specific target cells?; Extracellular vesicle mediated embryo maternal communication

Autores: Keerthie Dissanayake; Keerthie Dissanayake; Keerthie Dissanayake; Kasun Godakumara; Kasun Godakumara; Subhashini Muhandiram; Suranga Kodithuwakku; Suranga Kodithuwakku; Alireza Fazeli; Alireza Fazeli; Alireza Fazeli
Publicado en: Frontiers in Molecular Biosciences, 2024, ISSN 2296-889X
Editor: Frontiers
DOI: 10.3389/FMOLB.2024.1415909

Use of Decellularized Bio-Scaffolds for the Generation of a Porcine Artificial Intestine

Autores: Arcuri, Sharon; PENNAROSSA, GEORGIA; Prasadani, Madhusha; Gandolfi, Fulvio; Brevini, Tiziana A.L.
Publicado en: Methods and Protocols, 2024, ISSN 2409-9279
Editor: MDPI
DOI: 10.3390/MPS7050076

International Journal of Molecular Sciences

Autores: Prasadani, Madhusha; Kodithuwakku, Suranga; PENNAROSSA, GEORGIA; Fazeli, Alireza; Brevini, Tiziana A.L.
Publicado en: International Journal of Molecular Sciences, 2024, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/IJMS25105543

PLoS ONE

Autores: Soeorg, Hiie; Abroi, Aare; Päll, Taavi; Dotsenko, Liidia; Jaaniso, Erik; Kaarna, Katrin; Lahesaare, Andrio; Naaber, Paul; Niglas, Heiki; Oopkaup, Ott Eric; Peterson, Hedi; Reisberg, Tuuli; Sadikova, Olga; Smit, Steven; Talas, Ulvi Gerst; Avi, Radko; Lutsar, Irja; Huik, Kristi
Publicado en: PLOS ONE, 2024, ISSN 1932-6203
Editor: Zenodo
DOI: 10.1371/JOURNAL.PONE.0303176