Objective In the EU, 1 in 35 women and 1 in 23 men will be diagnosed with colorectal cancer (CRC) in their life span (ca. 340,000 cases and 156,000 deaths in 2020) causing an annual economic burden of ca. 20 billion EUR. Identifying CRC early enables better treatment options. Screening usually entails a quantitative faecal immunological test (FIT) to predict the need of colonoscopy for the detection of colorectal lesions, an expensive and invasive procedure. We aim to predict this need with specificity increased by >20 percentage points by using metagenomic microbiomes. We hypothesise that computational microbiome profiles extracted using artificial intelligence (Al) technology will allow for optimised personal therapy stratification. However, clinicians do not have access to broad microbiome data. With Microb-AI-ome, we will develop a novel kind of computational stratification technology to enable microbiome-enhanced precision medicine of CRC. Metagenomic microbiome data to date is distributed over many national registries, and privacy regulations are hindering its effective integration. With Microb-AI-ome, we will overcome this barrier by establishing the first privacy-preserving federated big data network in CRC research. We will integrate isolated, national databases into one international federated database network - rather than a cloud - covering metagenomes for over 5,000 individuals screened for CRC, and an expected total of 100,000 by 2026. Microb-AI-ome ensures that no sensitive patient data will leave the safe harbours of the local databases while still allowing for the classification of clinical CRC phenotypes, which we will demonstrate in clinical practice allowing regulatory bodies to adopt evidence-based guidelines. Our consortium combines expertise in CRC and its treatment, microbiomics, artificial intelligence, software development, and privacy protection to close the gap between privacy and big data in international medical research. Fields of science natural sciencescomputer and information sciencesartificial intelligencenatural sciencescomputer and information sciencesdatabasesnatural sciencescomputer and information sciencesdata sciencebig datamedical and health sciencesclinical medicineoncologycolorectal cancernatural sciencesbiological sciencesmicrobiology Keywords privacy by design federated database network colorectal cancer microbiomes Programme(s) HORIZON.2.1 - Health Main Programme HORIZON.2.1.5 - Tools, Technologies and Digital Solutions for Health and Care, including personalised medicine Topic(s) HORIZON-HLTH-2022-TOOL-12-01-two-stage - Computational models for new patient stratification strategies Call for proposal HORIZON-HLTH-2022-TOOL-12-two-stage See other projects for this call Funding Scheme HORIZON-RIA - HORIZON Research and Innovation Actions Coordinator UNIVERSITAET HAMBURG Net EU contribution € 1 280 175,00 Address MITTELWEG 177 20148 Hamburg Germany See on map Region Hamburg Hamburg Hamburg Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 280 175,00 Participants (7) Sort alphabetically Sort by Net EU contribution Expand all Collapse all UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK Ireland Net EU contribution € 688 748,75 Address WESTERN ROAD T12 YN60 Cork See on map Region Ireland Southern South-East Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 688 748,75 GNOME DESIGN SRL Romania Net EU contribution € 500 000,00 Address STR DAKO 2A 520014 Sfantu Gheorghe See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Macroregiunea Unu Centru Covasna Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 500 000,00 TP21 GMBH Germany Net EU contribution € 400 000,00 Address LUISENSTRASSE 14 10117 Berlin See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Berlin Berlin Berlin Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 400 000,00 RESEARCH INSTITUTE AG & CO KG Austria Net EU contribution € 631 367,50 Address AMUNDSENSTRASSE 9 1170 Wien See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Ostösterreich Wien Wien Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 631 367,50 INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT France Net EU contribution € 1 163 092,50 Address 147 RUE DE L'UNIVERSITE 75007 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 163 092,50 ASSISTANCE PUBLIQUE HOPITAUX DE PARIS France Net EU contribution € 675 000,00 Address 55 BOULEVARD DIDEROT 75012 Paris See on map Region Ile-de-France Ile-de-France Val-de-Marne Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 675 000,00 MATER MISERICORDIAE UNIVERSITY HOSPITAL Ireland Net EU contribution € 658 435,00 Address ECCLES STREET 7 Dublin See on map Region Ireland Eastern and Midland Dublin Activity type Other Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 658 435,00
