A TRUSTworthy speech-based AI monitorING system for the prediction of relapse in individuals with schizophrenia

Project Information

TRUSTING

Grant agreement ID: 101080251

DOI

10.3030/101080251

EC signature date 5 April 2023

Start date 1 July 2023

End date 31 December 2028

Funded under

• Health

Total cost

€ 5 999 510,00

EU contribution

€ 5 999 510,00

Coordinated by

ACADEMISCH ZIEKENHUIS GRONINGEN
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Demonstrators, pilots, prototypes (1)

e-health course

E-health course ready

Websites, patent fillings, videos etc. (1)

Website

Launching website for TRUSTING Project

Publications

Other (4)

How stable is the semantic space, and what stabilizes it?

Author(s): Rui He, Yan Cong, Trisha Godara, Claudio Palominos, Wolfram Hinzen

Task-voting for schizophrenia spectrum disorders prediction using machine learning across linguistic feature domains.

Author(s): Rui He, Víctor Ortiz-García de la Foz, Luis Manuel Fernández Cacho, Philipp Homan, Iris Sommer, Rosa Ayesa-Arriola, Wolfram Hinzen
Published in: 2024
Publisher: medRxiv
DOI: 10.1101/2024.08.31.24312886

Predicting PANSS symptoms in schizophrenia spectrum disorders using speech only: an international, multi-centre, retrospective, computational study across multiple languages

Author(s): Rui He, Maryia Kirdun, Claudio Palominos, Lara Navarrete Orejudo, Sophie Barthelemy, Simran Bhola, Silvia Ciampelli, Amandine Decker, Cemal Demirlek, Riccardo Fusaroli, José Tomás García-Molina, Guy Gimenez, Roya Hüppi, Katja Koelkebeck..., Wolfram Hinzen
Published in: medRxiv, 2026
Publisher: medRxiv
DOI: 10.64898/2026.02.20.26345632

e-health course

Peer reviewed articles (12)

The global economic burden of schizophrenia: an umbrella review of systematic reviews and meta-analyses with reconstructed primary-study cost data

Author(s): Attila Imre, Ágota Mészáros, Bertalan Németh, Balázs Nagy, Judit Józwiak-Hagymásy, Giacomo Cecere, Philipp Homan, Iris E. C. Sommer, Balázs Babarczy
Published in: Health Economics Review, Issue 16, 2026, ISSN 2191-1991
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/S13561-026-00766-4

Navigating the semantic space: Unraveling the structure of meaning in psychosis using different computational language models

Author(s): Rui He, Claudio Palominos, Han Zhang, Maria Francisca Alonso-Sánchez, Lena Palaniyappan, Wolfram Hinzen
Published in: Psychiatry Research, Issue 333, 2025, ISSN 0165-1781
Publisher: Elsevier BV
DOI: 10.1016/J.PSYCHRES.2024.115752

A single composite index of semantic behavior tracks symptoms of psychosis over time

Author(s): Claudio Palominos, Maryia Kirdun, Amir H. Nikzad, Michael J. Spilka, Philipp Homan, Iris E. Sommer, Sunny X. Tang, Wolfram Hinzen
Published in: Schizophrenia Research, Issue 279, 2025, ISSN 0920-9964
Publisher: Elsevier BV
DOI: 10.1016/J.SCHRES.2025.03.038

The ‘L-factor’: Language as a transdiagnostic dimension in psychopathology

Author(s): Wolfram Hinzen, Lena Palaniyappan
Published in: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Issue 131, 2024, ISSN 0278-5846
Publisher: Elsevier BV
DOI: 10.1016/J.PNPBP.2024.110952

Approximating the semantic space: word embedding techniques in psychiatric speech analysis

Author(s): Claudio Palominos, Rui He, Karla Fröhlich, Rieke Roxanne Mülfarth, Svenja Seuffert, Iris E. Sommer, Philipp Homan, Tilo Kircher, Frederike Stein, Wolfram Hinzen
Published in: Schizophrenia, Issue 10, 2024, ISSN 2754-6993
Publisher: Nature Mental Health 
DOI: 10.1038/S41537-024-00524-7

Using AI to Detect Psychosis Relapse: Scoping Review

Author(s): Lorenzo Ghelfi, Jack Healy, Francesco Piacenza, Ian French, Nicholas McNamara, Khyber Afridi Rabbi, Benjamin Bond, Emma O'Hora, Darren Roddy, Moyyad Kamali, Sudipto Das, Sandra Anna Just, Enrico Tedeschi, Musarrat Hussain, Karl Øyvind Mikalsen, Stefan Kaiser, Giacomo Cecere, Sanne Koops, Janna de Boer, Elysie Nguyen, Emre Bora, Wolfram Hinzen, Philipp Homan, Iris E Sommer, David Cotter, Mary Cannon, John Paul Lyne
Published in: JMIR Mental Health, Issue 13, 2026, ISSN 2368-7959
Publisher: JMIR Publications Inc.
DOI: 10.2196/92192

Automated Speech-Based Modeling of Item-Level Symptom Severity in Schizophrenia

Author(s): Silvia Ciampelli, Janna N. de Boer, Sanne Koops, Evan Troelstra, Almut Jebens, Jan-Bernard C. Marsman, Arnout C. Smit, Amir Hossein Nikzad, Ryan Partlan, Philipp Homan, Wolfram Hinzen, Sunny X. Tang, Iris E. C. Sommer
Published in: JAMA Network Open, Issue 9, 2026, ISSN 2574-3805
Publisher: American Medical Association (AMA)
DOI: 10.1001/JAMANETWORKOPEN.2026.20239

A double index for tracking symptoms in psychosis based on acoustic and semantic information

Author(s): Maryia Kirdu, Rui He, Cemal Demirlek, José Tomás García-Molina, Roya Hüppi, Werner Surbeck, Noemi Dannecker, Burcu Verim, Berna Yalincetin, Victor Ortiz García de la Foz, Rosa Ayesa Arriola, ..., Wolfram Hinzen, Claudio Palominos
Published in: Schizophrenia Research, ISSN 3067-2007
Publisher: Elsevier Inc.
DOI: 10.64898/2026.08.11.26360092

The challenges of implementing hybrid baselines for the interpretation of longitudinal behavioral data from individuals

Author(s): Sandra Anna Just, Enrico Tedeschi, Einar Holsbø, Karl Øyvind Mikalsen, Lars Ailo Bongo, Philipp Homan, Brita Elvevåg
Published in: npj Digital Medicine, Issue 9, 2026, ISSN 2398-6352
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41746-026-02668-5

What is the retest reliability of computationally extractable speech and language markers?

Author(s): Derya Çokal, Martin Villalba, Rui He, Claudio Flores Palominos, Annkathrin Böke, Philipp Homan, Klaus von Heusinger, Joseph Kambeitz, Wolfram Hinzen
Published in: Computer Speech & Language, Issue 100, 2026, ISSN 0885-2308
Publisher: Elsevier Inc.
DOI: 10.1016/J.CSL.2026.101981

Uncertainty modeling in multimodal speech analysis across the psychosis spectrum

Author(s): Morteza Rohanian, Roya Hüppi, Farhad Nooralahzadeh, Noemi Dannecker, Yves Pauli, Werner Surbeck, Iris Sommer, Wolfram Hinzen, Nicolas Langer, Michael Krauthammer, Philipp Homan
Published in: npj Digital Medicine, Issue 9, 2026, ISSN 2398-6352
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41746-025-02309-3

Prompt Engineering an Informational Chatbot for Educating about Mental Health: Utilizing a Multi-Agent Approach for Enhanced Compliance with Prompt Instruction

Author(s): Per Niklas Waaler, Musarrat Hussain, Igor Molchanov, Lars Ailo Bongo, Brita Elvevåg
Published in: JMIR AI, 2025, ISSN 2817-1705
Publisher: JMIR Publications
DOI: 10.48550/ARXIV.2410.12848

Conference proceedings (1)

EE194 Economic Burden of Schizophrenia: An Umbrella Review of Direct and Indirect Costs

Author(s): A Imre, B Babarczy, Á Mészáros, B Németh, B Nagy
Published in: Value in Health, Issue 27, 2025, ISSN 1098-3015
Publisher: Elsevier BV
DOI: 10.1016/J.JVAL.2024.10.478