Next Generation Vaccine Platform Leveraging Skin Immunity to Provide Disease-Modifying Treatment of Parkinson’s Disease

Project Information

NEXGEN-PD

Grant agreement ID: 101080267

DOI

10.3030/101080267

EC signature date 15 March 2023

Start date 1 April 2023

End date 31 March 2027

Funded under

Health

Total cost

€ 6 071 762,50

EU contribution

€ 6 071 762,50

6 071 762,50

Coordinated by

TRIDEM BIOSCIENCE GMBH & CO KG
Austria

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Comparison of 4 different vaccine schedules combined with different doses of vaccine induced immune response in vivo

Determined by assessing the key immune response parameters in blood and tissue in mice

Demonstration of superior immune response resulting from the modification of conventional GCVs with WISIT technology

Comparing responses generated against aSyn and at least 2 infectious disease epitopes, assessing the key immune response parameters in blood and tissue in mice

Initial Communication and Dissemination Plan

To be updated as the project progresses

Comparison of 4 different ID application methods effects on vaccine induced immune response in vivo

Determined by assessing the key immune response parameters in blood and tissue in mice

Definition of care as usual and final conceptual model for PD

as necessary to evaluate the economic impact of WISIT and extracellular vesicle-based biomarkers

Cross reactivity of vaccine induced aSyn antibodies generated by the top 3 PD-WISIT candidates

measuring reactivity to human and murine aSyn, βSyn and γSyn, without cross reactivity to βSyn and/or γSyn

Publications

PLoS ONE

Author(s): Sabine Schmidhuber; James Dickie; Mihály Cserepes; József Tóvári; Achim Schneeberger; Markus Mandler
Published in: PLOS ONE, 2025, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/JOURNAL.PONE.0318293

Human Cardiac Microtissues Display Improved Engraftment and Survival in a Porcine Model of Myocardial Infarction

Author(s): Evelyne Demkes; Aina Cervera-Barea; Patricia Ebner-Peking; Martin Wolf; Sarah Hochmann; Amy S. Scheren; Mayke Bijsterveld; C. Marlies van Oostveen; Marlijn Jansen; Joyce Visser; Wiebke Triebert; Caroline Halloin; Johannes G. G. Dobbe; Judith de Vos; Melanie Schürz; Joachim Danmayr; Maurice C. G. Aalders; Gerard J. J. Boink; Klaus Neef; Dirk Strunk; Robert Zweigerdt; Saskia C. A. de Jager; Joost P. G. Sluijter
Published in: Journal of Cardiovascular Translational Research, 2025, ISSN 1937-5395
Publisher: Springer Nature
DOI: 10.1007/S12265-025-10596-0

Selective EV Protein Sorting and Pathway Perturbation in AML Upon Synergistic FLT3 and Hedgehog Pathway Inhibition

Author(s): Blöchl, Constantin; Blümel, Gabriele; Wolf, Martin; Regl, Christof; Binder, Heide‐Marie; Tesanovic, Suzana; Lankes, Daniel; Maeding, Nicole; Krenn, Peter W.; Strunk, Dirk; Aberger, Fritz; Huber, Christian G.
Published in: Journal of Extracellular Vesicles, 2025, ISSN 2001-3078
Publisher: Taylor & Francis
DOI: 10.1002/JEV2.70163

T-cell repertoire correlates with cytokine imbalance in multiple sclerosis patients

Author(s): Lisa Weidner; Lisa Weidner; Rodolphe Poupardin; Tobias Zrzavy; Sandra Laner-Plamberger; Georg Gratz; Tanja Eichhorn; Viktoria Weber; Paulus S. Rommer; Christof Jungbauer; Christof Jungbauer; Dirk Strunk; Dirk Strunk
Published in: Frontiers in Immunology, 2025, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/FIMMU.2025.1604452

Effective vaccines for non-communicable diseases - A pipe dream?

Author(s): Markus Mandler
Published in: Crossref, 2024
Publisher: Open Access Government
DOI: 10.56367/oag-041-11136

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Deliverables

Publications

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