Autoantigen-specific adoptive regulatory T cell therapy against type 1 diabetes (ARTiDe)

Información del proyecto

ARTiDe

Identificador del acuerdo de subvención: 101080823

DOI

10.3030/101080823

Fecha de la firma de la CE 27 Abril 2023

Fecha de inicio 1 Julio 2023

Fecha de finalización 30 Junio 2028

Financiado con arreglo a

• Health

Coste total

€ 6 998 037,50

Aportación de la UE

€ 6 998 037,50

Coordinado por

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

Periodic Reporting for period 1 - ARTiDe (Autoantigen-specific adoptive regulatory T cell therapy against type 1 diabetes (ARTiDe))

Período documentado: 2023-07-01 hasta 2024-12-31

Resumen del contexto y de los objetivos generales del proyecto

The ARTiDe project aims to develop an innovative therapy for type 1 diabetes (T1D) by engineering regulatory T lymphocytes (Tregs) to suppress autoimmunity. By integrating advanced immunological research, genetic engineering, and clinical translation, ARTiDe seeks to enhance personalized immunotherapy for T1D patients. The project involves characterizing T cell responses, evaluating the efficacy and safety of engineered Tregs, developing strategies to maintain their suppressive function, and advancing genetic modification processes for clinical application. Additionally, a comprehensive communication and effective management strategy is implemented to maximize the project's scientific and societal impact.

Trabajo realizado desde el comienzo del proyecto hasta el final del período abarcado por el informe y los principales resultados hasta la fecha

The consortium partners are actively collaborating to achieve the ARTiDe project's objectives, ensuring steady progress across all work packages. They have characterized Treg responses to β-cell antigens, developed insulin-specific TCRs, and established a humanized mouse model for testing. Additionally, partners are working on nanoparticles to stimulate regulatory T cells and optimizing clinical-grade processes for Treg modification. The project has also developed its identity and communication materials, established an Innovation Management Board for IP management, and ensured efficient project management and reporting. Through these efforts, ARTiDe is making significant strides toward developing a T cell-based therapy for T1D, integrating advanced immunological research, genetic engineering, and clinical translation.

Avances que van más allá del estado de la técnica e impacto potencial esperado (incluida la repercusión socioeconómica y las implicaciones sociales más amplias del proyecto hasta la fecha)

At this stage of the ARTiDe project, significant milestones have been achieved. A breakthrough analysis pipeline has been developed to characterize Treg responses against β-cell antigens and identify related TCR sequences, providing a solid foundation for further validation and analysis. The project has the potential to establish a first of its kind highly targeted therapy for T1D, with a tailored preclinical model that could standardize antigen-specific immune therapies. Preliminary results also suggest that proinsulin-carrying nanoparticles selectively accumulate in pancreatic islets, attracting T lymphocytes and reducing islet inflammation.