THERAPEUTIC EPIGENETIC ENHANCEMENT OF THE INNATE IMMUNITY TO EFFECTIVELY COMBAT ANTIMICROBIAL RESISTANCE [IN-ARMOR]

Project Information

IN-ARMOR

Grant agreement ID: 101080889

DOI

10.3030/101080889

EC signature date 15 March 2023

Start date 1 May 2023

End date 30 April 2027

Funded under

• Health

Total cost

€ 5 998 972,50

EU contribution

€ 5 998 972,25

Coordinated by

HASKOLI ISLANDS
Iceland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (5)

Plan for Dissemination of Results (PDR), with Project Communication Plan (PCP)

Document containing the definition of the dissemination of results and communication plan and tools to be used during the life of the project. All possible dissemination routes for the obtained results will be identified and used during the whole course of the project.

Review of costs related to GI diseases. Elaboration of a scientific health-economics report with results from CEA based on current available studies on GI diseases.

The Document will consider data on the resources used in different treatment strategies of immunotherapies for GI diseases and the unit cost or price per resource and the main effects in terms of health gain. The analysis will capture the variability in the use and costs of the resources between multi-clinical units and in relation to patient status.

Policy Briefing II

On-page policy briefing to be shared with policy makers and their DGs. The document will list the achievements and results to date, pathways to impact and next steps to be taken.

Health Technology Assessment structure definition.

Document presenting the basic structure of the HTA report, which will be continuously fulfilled as results of project are produced  and the information for these  parts of the HTA will be known: problem and new therapy description,  clinical effectiveness and safety,  costs and economic evaluation,  ethical aspects,  organisational aspects,  patients and social aspects. HTA report will present the projects outcomes and its effects on society, that may occur when a therapy is introduced, extended, or modified, with emphasis on the impacts that are direct but also unintended or indirect.

Policy Briefing I

On-page policy briefing to be shared with policy makers and their DGs. The document will list the achievements and results to date, pathways to impact and next steps to be taken.

Websites, patent fillings, videos etc. (1)

In-Armor public website and social channels

Document describing In-Armor webpage prepared in the first month of the project.

Publications

Peer reviewed articles (4)

Impact of HDAC inhibitors on macrophage polarization to enhance innate immunity against infections

Author(s): Mohammad Faizan Bhat, Sonja Srdanović, Lotta-Riina Sundberg, Helga Kristín Einarsdóttir, Varpu Marjomäki, Frank J. Dekker
Published in: Drug Discovery Today, Issue 29, 2024, ISSN 1359-6446
Publisher: Elsevier BV
DOI: 10.1016/j.drudis.2024.104193

Cost-effectiveness of treatment and care of patients with gastrointestinal inflammatory diseases: a systematic review

Author(s): Kristina Randlová, Petra Marešová, Lukáš Režný, Jan Hruška, Sonja Srdanović, Guðmundur H. Guðmundsson, Egill Másson, Kamil Kuča
Published in: Journal of Medical Economics, Issue 29, 2026, ISSN 1369-6998
Publisher: Informa UK Limited
DOI: 10.1080/13696998.2026.2637360

Host-directed therapies modulating innate immunity against infection in hematologic malignancies

Author(s): Qiong Wang, Kristján Hermannsson, Egill Másson, Peter Bergman, Guðmundur Hrafn Guðmundsson
Published in: Blood Reviews, 2024, ISSN 0268-960X
Publisher: Elsevier BV
DOI: 10.1016/j.blre.2024.101255

Histone Deacetylase 3‐Directed PROTACs Have Anti‐inflammatory Potential by Blocking Polarization of M0‐like into M1‐like Macrophages

Author(s): Chunlong Zhao, Shipeng Chen, Deng Chen, Clàudia Río‐Bergé, Jianqiu Zhang, Petra E. Van Der Wouden, Toos Daemen, Frank J. Dekker
Published in: Angewandte Chemie International Edition, Issue 62, 2023, ISSN 1433-7851
Publisher: Wiley
DOI: 10.1002/ANIE.202310059