Human blastoids: a drug discovery platform for women’s reproductive health

Project Information

BLASTOID-DISCOVERY

Grant agreement ID: 101082147

DOI

10.3030/101082147

Project closed

EC signature date 4 October 2023

Start date 1 November 2023

End date 30 April 2025

Funded under

• European Research Council (ERC)

Total cost

No data

EU contribution

€ 150 000,00

Coordinated by

INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH
Austria

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (9)

FoxO transcription factors actuate the formative pluripotency specific gene expression programme

Author(s): Laura Santini, Saskia Kowald, Luis Miguel Cerron-Alvan, Michelle Huth, Anna Philina Fabing, Giovanni Sestini, Nicolas Rivron, Martin Leeb
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41467-024-51794-9

Challenging the Astral mass analyzer to quantify up to 5,300 proteins per single cell at unseen accuracy to uncover cellular heterogeneity

Author(s): Julia A. Bubis, Tabiwang N. Arrey, Eugen Damoc, Bernard Delanghe, Jana Slovakova, Theresa M. Sommer, Harunobu Kagawa, Peter Pichler, Nicolas Rivron, Karl Mechtler, Manuel Matzinger
Published in: Nature Methods, Issue 22, 2025, ISSN 1548-7091
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41592-024-02559-1

Hypoblast from human pluripotent stem cells regulates epiblast development

Author(s): Takumi Okubo, Nicolas Rivron, Mio Kabata, Hideki Masaki, Keiko Kishimoto, Katsunori Semi, May Nakajima-Koyama, Haruko Kunitomi, Belinda Kaswandy, Hideyuki Sato, Hiromitsu Nakauchi, Knut Woltjen, Mitinori Saitou, Erika Sasaki, Takuya Yamamoto, Yasuhiro Takashima
Published in: Nature, Issue 626, 2024, ISSN 0028-0836
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41586-023-06871-2

An update on human pre- and peri-implantation development: a blueprint for blastoids

Author(s): Laurent David, Alexandre Bruneau, Thomas Fréour, Nicolas Rivron, Hilde Van de Velde
Published in: Current Opinion in Genetics & Development, Issue 83, 2023, ISSN 0959-437X
Publisher: Elsevier BV
DOI: 10.1016/J.GDE.2023.102125

mTOR activity paces human blastocyst stage developmental progression

Author(s): Dhanur P. Iyer, Heidar Heidari Khoei, Vera A. van der Weijden, Harunobu Kagawa, Saurabh J. Pradhan, Maria Novatchkova, Afshan McCarthy, Teresa Rayon, Claire S. Simon, Ilona Dunkel, Sissy E. Wamaitha, Kay Elder, Phil Snell, Leila Christie, Edda G. Schulz, Kathy K. Niakan, Nicolas Rivron, Aydan Bulut-Karslioğlu
Published in: Cell, Issue 187, 2024, ISSN 0092-8674
Publisher: Elsevier BV
DOI: 10.1016/J.CELL.2024.08.048

Criteria for the standardization of stem-cell-based embryo models

Author(s): Alfonso Martinez Arias, Nicolas Rivron, Naomi Moris, Patrick Tam, Cantas Alev, Jianping Fu, Anna-Katerina Hadjantonakis, Jacob H. Hanna, Gabriella Minchiotti, Olivier Pourquie, Guojun Sheng, Liliana Solnica Krezel, Jesse V. Veenvliet, Aryeh Warmflash
Published in: Nature Cell Biology, Issue 26, 2024, ISSN 1465-7392
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41556-024-01492-X

Generating human blastoids modeling blastocyst-stage embryos and implantation

Author(s): Heidar Heidari Khoei, Alok Javali, Harunobu Kagawa, Theresa Maria Sommer, Giovanni Sestini, Laurent David, Jana Slovakova, Maria Novatchkova, Yvonne Scholte op Reimer, Nicolas Rivron
Published in: Nature Protocols, Issue 18, 2024, ISSN 1754-2189
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41596-023-00802-1

An ethical framework for human embryology with embryo models

Author(s): Nicolas C. Rivron, Alfonso Martinez Arias, Martin F. Pera, Naomi Moris, Hafez Ismaili M’hamdi
Published in: Cell, Issue 186, 2024, ISSN 0092-8674
Publisher: Elsevier BV
DOI: 10.1016/J.CELL.2023.07.028

Changing the public perception of human embryology

Author(s): Nicolas C. Rivron, Alfonso Martinez-Arias, Karen Sermon, Christine Mummery, Hans R. Schöler, James Wells, Jenny Nichols, Anna-Katerina Hadjantonakis, Madeline A. Lancaster, Naomi Moris, Jianping Fu, Roger G. Sturmey, Kathy Niakan, Janet Rossant, Kazuto Kato
Published in: Nature Cell Biology, Issue 25, 2023, ISSN 1465-7392
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41556-023-01289-4