The SAFE project has achieved significant progress in various areas, aiming to reduce nutrient emissions from freshwater aquaculture by utilizing liquid and solid effluents in biomass production. To this end, different systems such as recirculating aquaculture systems (RAS), integrated multi-trophic aquaculture (IMTA), ponds, and flow-through systems were tested, considering seasonal variations in water quality, effluents, and sludge. Analyses of samples for macronutrients and trace elements, including pesticides, antibiotics, and particle sizes, revealed no concerns of harmful chemical compounds. The project explored several innovations in aquaculture, resulting in advancements in production system designs, waste management, aquafeed development, and digital innovations. One notable achievement is the creation of a low-cost, natural filtering system prototype using straw bricks for pond aquaculture. Enriched straw bricks were also tested as substrates for oyster mushroom cultivation. Additionally, a novel heat pump was developed to dry and utilize sludge effectively. Assessments were conducted to evaluate the impact of aquaculture on local biodiversity before and after applying SAFE technologies, including seasonal measurements of physiochemical parameters and macrobenthos sampling. In Ireland, the species diversity of benthic invertebrates was assessed, with diatom samples currently under analysis. In Poland, benthic diatom and macroinvertebrate samples from inflow and outflow channels were collected. Microalgae cultivation using processed wastewater from RAS was investigated to ensure water purity, with semi-continuous cultivation optimized for fish feed trials and lipid production. Aquaponics systems using liquid effluent from RAS were tested for growing edible vegetables and fruits, all of which showed positive growth trends while maintaining good water quality. For mushroom cultivation, two substrates were tested: straw bales enriched with sediments from common carp pond farming and insect frass from mealworms. Best yield results came from straw bales, leading to a commercial-scale trial. Initial trials on worms indicated that they consumed duckweed and sludge but did not mature and reproduce as expected, prompting further trials to investigate different ratios of them. An on-site redworm rearing workshop for carp farmers is planned at the National Carp Conference. Furthermore, mealworm trials tested three substrates: duckweed, watercress, and spent mushroom substrate (SMS), with results showing better growth with less watercress or duckweed. Future trials will use new substrates with varying percentages of straw and sediment to optimize mealworm growth. In summary, the SAFE project is making strides in reducing nutrient emissions, enhancing aquaculture systems, and promoting sustainable practices through innovative technologies and comprehensive assessments.