SAFE has made substantial progress in characterising and utilising waste streams from freshwater aquaculture and in demonstrating circular concepts at pilot and farm scale. Across RAS, pond, IMTA, and flow-through systems, seasonal sampling of water, effluents, and sludge has been performed for macronutrients, trace elements, particle size, pesticides, antibiotics, and microbial indicators, revealing no critical levels of harmful compounds. On this basis, several innovations have been designed, built, and tested: a low-cost, natural sediment filtration system based on straw bricks has been installed in carp ponds, with nutrient-enriched bricks subsequently used as substrates for oyster mushroom cultivation; a transcritical CO2 heat pump dryer has been developed and demonstrated for efficient sludge drying; and processed RAS wastewater has been successfully used for semi-continuous microalgae cultivation for feed trials and lipid (EPA) enrichment. Aquaponics trials using RAS effluents have shown that vegetables and fruits can be grown with good water quality. Substrates derived from pond sediments, insect frass, duckweed, watercress, and spent mushroom substrate have been tested for mushroom, redworm, and mealworm production, with follow-up trials planned to refine mixtures that support growth and reproduction. Biodiversity assessments before and after the application of SAFE technologies have been conducted in Norway, Poland, and Ireland, showing no deterioration in benthic or diatom communities and, in some cases, improved conditions downstream of interventions. In parallel, digital innovations – including new optimisation modules in Cobália and major upgrades to the image-based fish measurement system – have progressed, laying the foundations for more efficient and sustainable farm management decisions.