Targeted Protein Degradation as a New Experimental and Therapeutic Approach for Pancreatic Ductal Adenocarcinoma

Project Information

PROTAC-PDAC

Grant agreement ID: 101087045

DOI

10.3030/101087045

EC signature date 12 April 2023

Start date 1 December 2023

End date 30 November 2028

Funded under

• European Research Council (ERC)

Total cost

€ 1 999 401,00

EU contribution

€ 1 999 401,00

Coordinated by

CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (9)

Unhooking the Hook: Optimization of the Aurora A Targeting PROTAC <b>JB170</b> to <b>CCT400028</b> , an <i>In Vitro</i> Degrader Chemical Probe

Author(s): Jack A. O’Hanlon, Katrin Gutsche, Juliane Elisabeth Müller, Nihar Ranjan Prusty, Amin Mirza, Theodoros I. Roumeliotis, Hengzhang Yang, Mark Stubbs, Stephen T. Hallett, Lorenz Eing, Peter Craig McAndrew, Jyoti Sharma Choudhary, Yann-Vaï Le Bihan, John Caldwell, Rob L. M. van Montfort, Paul Workman, Elmar Wolf, Gary K. Newton, Lindsay E. Evans
Published in: Journal of Medicinal Chemistry, Issue 69, 2026, ISSN 0022-2623
Publisher: American Chemical Society (ACS)
DOI: 10.1021/ACS.JMEDCHEM.5C03024

Journal of Medicinal Chemistry

Author(s): Adrian Haag; Václav Němec; Pavlína Janovská; Jana Bartošíková; Bikash Adhikari; Juliane Müller; Martin P. Schwalm; Štěpán Čada; Uli Ohmayer; Henrik Daub; Yeojin Kim; Florian Born; Elmar Wolf; Vítězslav Bryja; Stefan Knapp
Published in: Journal of Medicinal Chemistry, 2024, ISSN 0022-2623
Publisher: American Chemical Society
DOI: 10.1021/ACS.JMEDCHEM.4C02201

Identification of suitable target/E3 ligase pairs for PROTAC development using a rapamycin-induced proximity assay (RiPA)

Author(s): Bikash Adhikari, Katharina Schneider, Mathias Diebold, Christoph Sotriffer, Elmar Wolf
Published in: eLife, Issue 13, 2024, ISSN 2050-084X
Publisher: eLife Sciences Publications, Ltd
DOI: 10.7554/ELIFE.98450

Spatial transcriptomics reveals molecular cues underlying the site specificity of the adult mouse oral mucosa and its stem cell niches

Author(s): Anna C. Seubert, Marion Krafft, Sarah Bopp, Moutaz Helal, Pranjali Bhandare, Elmar Wolf, Anna Alemany, Angela Riedel, Kai Kretzschmar
Published in: Stem Cell Reports, Issue 19, 2025, ISSN 2213-6711
Publisher: Elsevier BV
DOI: 10.1016/J.STEMCR.2024.10.007

Phenotypic screens identify SCAF1 as critical activator of RNAPII elongation and global transcription

Author(s): Pranjali Bhandare, Ashwin Narain, Julia Hofstetter, Teresa Rummel, Julia Wenzel, Christina Schülein-Völk, Stephanie Lamer, Ursula Eilers, Andreas Schlosser, Martin Eilers, Florian Erhard, Elmar Wolf
Published in: Nucleic Acids Research, Issue 53, 2025, ISSN 0305-1048
Publisher: Oxford University Press (OUP)
DOI: 10.1093/NAR/GKAE1219

Combined targeted and epigenetic-based therapy enhances antitumor immunity by stabilizing GATA6-dependent MHCI expression in pancreatic ductal adenocarcinoma

Author(s): JuanFei Peng, JiaJin Yang, Georgia Antonopoulou, Rui Fang, Bikash Adhikari, Markus Vogt, Elmar Wolf, Chong Sun, Shangce Du, Laura Godfrey, Aayush Gupta, Marija Trajkovic-Arsic, Nicole Teichmann, Barbara T. Grünwald, Niklas Krebs, Katja Steiger, Carolin Mogler, Kristina Althoff, Xin Wang, Giovanni Giglio, Sven-Thorsten Liffers, Konstantinos Savvatakis, Rickmer Braren, Rita T. Lawlor, Aldo Scarpa, Diana Behrens, Karl S. Lang, Phyllis F. Cheung, Jens T. Siveke
Published in: Nature Communications, Issue 17, 2026, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41467-026-69013-Y

Development of 2-Aminoadenine-Based Proteolysis-Targeting Chimeras (PROTACs) as Novel Potent Degraders of Monopolar Spindle 1 and Aurora Kinases

Author(s): Eleni Sflakidou; Bikash Adhikari; Christos Siokatas; Elmar Wolf; Vasiliki Sarli
Published in: ACS Pharmacology &amp; Translational Science, 2024, ISSN 2575-9108
Publisher: American Chemical Society
DOI: 10.1021/ACSPTSCI.4C00405

Targeting MYC effector functions in pancreatic cancer by inhibiting the ATPase RUVBL1/2

Author(s): Markus Vogt, Nevenka Dudvarski Stankovic, Yiliam Cruz Garcia, Julia Hofstetter, Katharina Schneider, Filiz Kuybu, Theresa Hauck, Bikash Adhikari, Anton Hamann, Yamila Rocca, Lara Grysczyk, Benedikt Martin, Anneli Gebhardt-Wolf, Armin Wiegering, Markus Diefenbacher, Georg Gasteiger, Stefan Knapp, Dieter Saur, Martin Eilers, Mathias Rosenfeldt, Florian Erhard, Seychelle M Vos, Elmar Wolf
Published in: Gut, Issue 73, 2025, ISSN 0017-5749
Publisher: BMJ
DOI: 10.1136/GUTJNL-2023-331519

Nature Chemical Biology

Author(s): Kristina Wagner; Jan Keiten-Schmitz; Bikash Adhikari; Upayan Patra; Koraljka Husnjak; François McNicoll; Dorothee Dormann; Michaela Müller-McNicoll; Georg Tascher; Elmar Wolf; Stefan Müller
Published in: Nature Chemical Biology, 2025, ISSN 1552-4450
Publisher: Springer Nature
DOI: 10.1038/S41589-025-01886-4