Charting Cell Type-Specific Nucleic Acid Immunity

Project Information

SENTINEL

Grant agreement ID: 101087092

DOI

10.3030/101087092

EC signature date 7 April 2023

Start date 1 October 2023

End date 30 September 2028

Funded under

• European Research Council (ERC)

Total cost

€ 2 000 000,00

EU contribution

€ 2 000 000,00

Coordinated by

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (6)

Cytoplasmic DNA sensors and their regulators

Author(s): Roger J. Eloiflin, Isabelle K. Vila, Nadine Laguette
Published in: Biomedical Journal, 2026, ISSN 2319-4170
Publisher: Elsevier BV
DOI: 10.1016/J.BJ.2026.100988

DNA-PK interacts with cyclic dinucleotides and inhibits type I interferon responses

Author(s): Isabelle K. Vila, Yasmine Messaoud-Nacer, Clara Taffoni, Jane Jardine, Roger J. Eloiflin, Adeline Augereau, Soumyabrata Guha, Moritz Schussler, Pierre Le Hars, Joe McKellar, Tamara Carvalho, Jeanne Postal, Morgane Chemarin, Joanna Re, Florence Guivel-Benhassine, Raphaëlle Lopez, Kilian Trillet, Jennifer Barrat, Maximin Serbier, Insaf El Mansouri, Charlotte Luchsinger, George P. Chrousos, Françoise Porrot, Felipe Diaz-Griffero, Olivier Schwartz, Fabien P. Blanchet, Karim Majzoub, Nicolas Bidère, Dimitrios Vlachakis, Nadine Laguette
Published in: Journal of Experimental Medicine, Issue 223, 2026, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/JEM.20251796

Targeting SUMOylation Triggers IFN-β–dependent Activation of Patient and Allogenic NK Cells in Preclinical Models of Acute Myeloid Leukemia

Author(s): Rawan Hallal; Marion de Toledo; Denis Tempé; Rayane Berrahouane; Sara Zemiti; Loïs Coënon; Delphine Gitenay; Simon George; Moritz Schüssler; Nadine Laguette; Sarah Bonnet; Ludovic Gabellier; Guillaume Cartron; Mireia Pelegrin; Martin Villalba; Guillaume Bossis
Published in: Molecular Cancer Therapeutics, 2025, ISSN 1538-8514
Publisher: America Association for Cancer Research
DOI: 10.1158/1535-7163.MCT-25-0504

Nature Communications

Author(s): Chamma, Hanane; Guha, Soumyabrata; Eloiflin, Roger; Augereau, Adeline; Le Hars, Pierre; Schüssler, Moritz; Messaoud-Nacer, Yasmine; Salma, Mohammad; Mckellar, Joe; Re, Joanna; Chemarin, Morgane; Carrier, Arnaud; Disyak, Michael; Taffoni, Clara; Charpentier, Robin; Husson, Zoé; Valjent, Emmanuel; Andrieu-Soler, Charlotte; Soler, Eric; Christensen, Maria; Paludan, Søren; Schmidt, Florian; Tropea, Daniela; Majzoub, Karim; Vila, Isabelle; Laguette, Nadine
Published in: Nature Communications, 2025, ISSN 2041-1723
Publisher: Nature Communications
DOI: 10.1038/S41467-025-65713-Z

Deltaviruses spread through a viral Trojan Horse

Author(s): Mckellar, Joe; Fouillen, Aurélien; Lyonnais, Sébastien; Blanchard, Marie-Pierre; Seigneuret, Florian; Trullo, Antonio; Denis, Zoé; Sleiman, Roni; Le Bon, Brandon; Berry, Laurence; Kumarasinghe, Lorena; Bouget, Jules; Apostel, Arinya; Bacia-Verloop, Maria; de Rossi, Sylvain; Messaoud-Nacer, Yasmine; Colomb, Sophie; Desagher, Solange; Vila, Isabelle; Laguette, Nadine; Granier, Sébastien; de Rocquigny, Hugues; Gaudin, Raphael; Courgnaud, Valérie; Gutsche, Irina; Hepojoki, Jussi; Majzoub, Karim
Published in: Cell, 2026, ISSN 1097-4172
Publisher: Cell press
DOI: 10.1016/J.CELL.2026.01.037

Interferon stimulatory DNA activates the DNA damage signaling through ATM and DNA-PK sensing

Author(s): Samira Kemiha, Lorena Rejón-Franco, Estelle Ghibaudo, Roger J. Eloiflin, Morgane Chemarin, Karim Hawillo, Nadine Laguette, Hervé Técher
Published in: Journal of Biological Chemistry, Issue 302, 2026, ISSN 0021-9258
Publisher: Elsevier BV
DOI: 10.1016/J.JBC.2026.111362