Elucidating the Spatial and Temporal Dynamics of Acute Myeloid Leukemia Progression Using Functional Omics and High-Throughput In Vivo Screening

Project Information

DynAML

Grant agreement ID: 101088563

DOI

10.3030/101088563

EC signature date 13 June 2023

Start date 1 March 2024

End date 28 February 2029

Funded under

• European Research Council (ERC)

Total cost

€ 1 994 500,00

EU contribution

€ 1 994 500,00

Coordinated by

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (5)

Nature Communications

Author(s): Nabih Maslah; Nina Kaci; Blandine Roux; Gabriela Alexe; Raphael Marie; Hélène Pasquer; Emmanuelle Verger; Rafael Daltro De Oliveira; Cécile Culeux; Bochra Mlayah; Nicolas Gauthier; Fanny Gonzales; Lin-Pierre Zhao; Saravanan Ganesan; Panhong Gou; Frank Ling; Juliette Soret-Dulphy; Nathalie Parquet; William Vainchenker; Emmanuel Raffoux; Rose Ann Padua; Stéphane Giraudier; Caroline Marty; Isabelle Plo; Camille Lobry; Kimberly Stegmaier; Alexandre Puissant; Jean-Jacques Kiladjian; Bruno Cassinat; Lina Benajiba
Published in: Nature Communications, 2025, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/S41467-025-60884-1

Pathway coessentiality mapping reveals complex II is required for de novo purine biosynthesis in acute myeloid leukaemia

Author(s): Amy E. Stewart, Derek K. Zachman, Pol Castellano-Escuder, Lois M. Kelly, Ben Zolyomi, Michael D. I. Aiduk, Christopher D. Delaney, Ian C. Lock, Claudie Bosc, John Bradley, Shane T. Killarney, J. Darren Stuart, Paul A. Grimsrud, Olga R. Ilkayeva, Christopher B. Newgard, Navdeep S. Chandel, Alexandre Puissant, Kris C. Wood, Matthew D. Hirschey
Published in: Nature Metabolism, Issue 7, 2025, ISSN 2522-5812
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S42255-025-01410-X

PitViper: a software for comparative meta-analysis and annotation of functional screening data

Author(s): Paul-Arthur Meslin; Lois M Kelly; Salima Benbarche; Séverine Lecourt; Kevin H Lin; Justine C Rutter; Christopher F Bassil; Raphael Itzykson; Kris C Wood; Alexandre Puissant; Camille Lobry
Published in: NAR Genomics and Bioinformatics, 2024, ISSN 2631-9268
Publisher: Oxford University Press
DOI: 10.1093/NARGAB/LQAE059

Exploiting tumor lineage features for precision cancer therapy

Author(s): Lois M. Kelly, Nina Fenouille, Kris C. Wood, Alexandre Puissant
Published in: Trends in Cancer, Issue 12, 2026, ISSN 2405-8033
Publisher: Elsevier BV
DOI: 10.1016/J.TRECAN.2025.12.004

Targeting a lineage-specific PI3Kɣ–Akt signaling module in acute myeloid leukemia using a heterobifunctional degrader molecule

Author(s): Kelly, Lois; Rutter, Justine; Lin, Kevin; Ling, Frank; Duchmann, Matthieu; Latour, Emmanuelle; Arang, Nadia; Pasquer, Hélène; Ho Nhat, Duong; Charles, Juliette; Killarney, Shane; Ang, Hazel; Namor, Federica; Culeux, Cécile; Lombard, Bérangère; Loew, Damarys; Swaney, Danielle; Krogan, Nevan; Brunel, Luc; Carretero, Élodie; Verdié, Pascal; Amblard, Muriel; Fodil, Sofiane; Huynh, Tony; Sebert, Marie; Adès, Lionel; Raffoux, Emmanuel; Fenouille, Nina; Itzykson, Raphaël; Lobry, Camille; Benajiba, Lina; Forget, Antoine; Martin, Anthony; Wood, Kris; Puissant, Alexandre
Published in: Nature Cancer, 2024, ISSN 2662-1347
Publisher: Springer Nature
DOI: 10.1038/S43018-024-00782-5