Project description
Key players in plant stress responses
Plants respond to stress and regulate various physiological processes through a class of hormones known as jasmonates (JA), and in particular through the bioactive JA derivative, jasmonoyl-isoleucine (JA-lle). Although JA-lle biosynthesis and signalling have been well characterised, the precise signalling pathway in plants in reaction to tissue injury remains elusive. Funded by the European Research Council, the MECHANOJAS project aims to investigate the mechanical forces and osmotic pressure required for JA biosynthesis and to delineate the cellular events implicated in the transmission of stress signals. Identification of the components responsible for sensing and translating biophysical stimuli into JA-Ile production will improve our understanding of plant biology and help safeguard them against biotic and abiotic challenges.
Objective
Both animals and plants produce potently active mediators in response to tissue injury. These oxygenated lipid derivatives include leukotrienes and prostaglandins in animals, and jasmonates (JAs) in plants with JA-Ile serving as the bioactive phytohormone in angiosperms. JAs are synthesized from poly unsaturated fatty acids residing in plant-specific plastidial membranes, and are essential to protect plants against numerous biotic and abiotic challenges including insect herbivory and temperature extremes. Despite the vital roles of JAs in sustaining plant fitness and although JA-Ile biosynthesis and signalling are well characterized, it is still unknown how are damage signals transmitted to plastids to initiate phytohormone production and what is the nature of the transmitted signal(s). Our previous work in Arabidopsis uncovered that osmotically-induced turgor pressure changes elicit JA-Ile biosynthesis. We hence hypothesise that JA-Ile biosynthesis initiation may result from the transmission of mechanical signals through tissues and cell compartments leading to biophysical changes of plastidial membranes granting substrate accessibility to JA biosynthesis enzymes. To address these central questions in plant biology we aim to:
1. Quantify the mechanical forces and osmotic pressure changes required to induce JA biosynthesis
2. Characterize cellular events that transduce mechanical and osmotic stress signals to plastids for JA-Ile precursor production
3. Alter plastidial biophysical parameters and study the consequences on JA-Ile precursor production
4. Identify genetic components involved in sensing and decoding biophysical stimuli for JA-Ile production
This proposal thus intends to fill a critical gap in knowledge on stress phytohormone biology regulating plant acclimation and, concomitantly, expand our understanding on fundamental aspects of plant mechano- and osmo-sensing.
Fields of science (EuroSciVoc)
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CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
This project's classification has been validated by the project's team.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
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Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2022-COG
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06120 Halle
Germany
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