Towards Artificial Human Embryoid Models: Engineered and Synthetic Platforms for Ex Utero Mammalian Embryogenesis

Project Information

ExUteroEmbryogenesis

Grant agreement ID: 101089297

DOI

10.3030/101089297

EC signature date 25 May 2023

Start date 1 June 2023

End date 31 May 2028

Funded under

• European Research Council (ERC)

Total cost

€ 2 000 000,00

EU contribution

€ 2 000 000,00

Coordinated by

WEIZMANN INSTITUTE OF SCIENCE
Israel

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (4)

Temporal BMP4 effects on mouse embryonic and extraembryonic development

Author(s): Ron Hadas; Hernan Rubinstein; Markus Mittnenzweig; Yoav Mayshar; Raz Ben-Yair; Saifeng Cheng; Alejandro Aguilera-Castrejon; Netta Reines; Ayelet-Hashahar Orenbuch; Aviezer Lifshitz; Dong-Yuan Chen; Michael B. Elowitz; Magdalena Zernicka-Goetz; Jacob H. Hanna; Amos Tanay; Yonatan Stelzer
Published in: Nature, 2024, ISSN 1476-4687
Publisher: Nature
DOI: 10.1038/S41586-024-07937-5

Putting together pieces of the LIN28A pathway puzzle

Author(s): Alperen Yilmaz; Gulben Gurhan; Jacob H. Hanna
Published in: Nature Structural & Molecular Biology, 2024, ISSN 1545-9985
Publisher: Nature
DOI: 10.1038/S41594-024-01380-W

Complete human day 14 post-implantation embryo models from naive ES cells

Author(s): Bernardo Oldak; Emilie Wildschutz; Vladyslav Bondarenko; Mehmet-Yunus Comar; Cheng Zhao; Alejandro Aguilera-Castrejon; Shadi Tarazi; Sergey Viukov; Thi Xuan Ai Pham; Shahd Ashouokhi; Dmitry Lokshtanov; Francesco Roncato; Eitan Ariel; Max Rose; Nir Livnat; Tom Shani; Carine Joubran; Roni Cohen; Yoseph Addadi; Muriel Chemla; Merav Kedmi; Hadas Keren-Shaul; Vincent Pasque; Sophie Petropoulos; Fredrik Lanner; Noa Novershtern; Jacob H. Hanna
Published in: Nature, 2023, ISSN 1476-4687
Publisher: Nature
DOI: 10.1038/S41586-023-06604-5

Transgene-free generation of mouse post-gastrulation whole embryo models solely from naive ESCs and iPSCs

Author(s): Alperen Yilmaz, Gulben Gurhan, Mehmet-Yunus Comar, Sergey Viukov, Inbal Serfaty, Mert Gayretli, Sergey Golenchenko, Dmitry Lokshtanov, Shahd Ashouokhi, Angel Polanco, Idan Berlad, Tae-Won Ha, Alejandro Aguilera-Castrejon, Shadi Tarazi, Marina Cohen, Nir Livnat, Komal Kumar, Hisham Cholakkal, Nathan Levy, Nir Yosef, Nizar Khatib, Reli Rachel Kakun, Merav Kedmi, Inbal Bolocan Nachman, Hadas Keren-Shaul, Yoseph Addadi, Ayelet-Hashahar Orenbuch, Karina Korovin, Alina Molchadsky, Konrad Hochedlinger, Ohad Gafni, Itay Maza, Noa Novershtern, Bernardo Oldak, Jacob H. Hanna
Published in: Cell Stem Cell, 2025, ISSN 1934-5909
Publisher: Elsevier BV
DOI: 10.1016/J.STEM.2025.07.005