Project description DEENESFRITPL Novel materials for reduced dental implant inflammation and infection Peri-implantitis is a condition associated with infections in the soft and hard tissues around dental implants that may ultimately lead to implant loss. It occurs in nearly 1 in 5 cases, creating a major issue in prosthetic dentistry. The key objective of the EU-funded NOMAD project is to develop innovative biomaterials for dental implants which have a lower risk of inflammation and infection. The proposal is to modify the surface of titanium or zirconia dental materials with multifunctional coatings that limit bacterial adhesion and at the same time promise to improve soft-tissue sealing and promote osseointegration. These innovative materials combining 3D printing, nanotechnology, and antimicrobial compounds will introduce a new generation of customisable products in the dental implant field. Show the project objective Hide the project objective Objective Peri-implant infections are a devastating complication of dental implants, occurring in approximately 20% of all patients, that can ultimately lead to implant instability and loss. Considering this high prevalence rate and the lack of predictive treatments in severe cases, prevention of peri-implantitis has become a major challenge in clinical dentistry.NOMAD will develop innovative biomaterial approaches for dental implants, from TRL3 to TRL5. Various functionalised implant coatings for titanium and zirconia implant surfaces will reduce the risk of infection (and associated inflammation), improve soft-tissue sealing at the gum line, and promote osseointegration. A further innovation are multi-material crowns and abutments using additive manufacturing combined with grafting of nanotubes, enabling controlled release of prebiotic as well as antimicrobial compounds in response to bacterial adhesion at the onset of infection (i.e. smart conditional release). A combination of these approaches will be employed in the final product to provide a customisable, all-round solution focusing on crown, abutment and/or fixture for prevention of peri-implantitis.Advanced in vitro testing using complex cell co-cultures in bioreactor systems, and biomechanical stability tests will enable selecting the most promising biomaterials for testing in relevant in vivo models. These results will enable rapid progression to first-in-human studies of new biomaterials after the project. A cost-benefit and regulatory analysis will be performed and an innovation management strategy will develop a roadmap for commercialisation. The NOMAD consortium includes a major dental implant manufacturer, academic groups, SMEs working on biomaterials innovation and a specialist innovation company. The project is a major opportunity for enhancing EU competitiveness in biomaterials and inter-sector technology transfer. Fields of science medical and health sciencesclinical medicineodontologydental implantologysocial scienceseconomics and businessbusiness and managementinnovation managementengineering and technologymechanical engineeringmanufacturing engineeringadditive manufacturingengineering and technologyindustrial biotechnologybiomaterialsmedical and health sciencesmedical biotechnologyimplants Programme(s) HORIZON.2.4 - Digital, Industry and Space Main Programme HORIZON.2.4.9 - Low-Carbon and Clean Industries HORIZON.2.4.4 - Advanced Materials Topic(s) HORIZON-CL4-2022-RESILIENCE-01-13 - Smart and multifunctional biomaterials for health innovations (RIA) Call for proposal HORIZON-CL4-2022-RESILIENCE-01 See other projects for this call Funding Scheme RIA - Research and Innovation action Coordinator KATHOLIEKE UNIVERSITEIT LEUVEN Net EU contribution € 1 506 218,00 Address Oude markt 13 3000 Leuven Belgium See on map Region Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Participants (11) Sort alphabetically Sort by Net EU contribution Expand all Collapse all Third-party Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure. HEALTH HOUSE Belgium Net EU contribution € 37 500,00 Address Gaston geenslaan 11 gebouw b4 3001 Heverlee See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven Activity type Other Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS France Net EU contribution € 451 203,75 Address Rue michel ange 3 75794 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Third-party Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure. ECOLE CENTRALE DE LYON France Net EU contribution € 32 891,25 Address Avenue guy de collongue 36 69134 Ecully See on map Region Auvergne-Rhône-Alpes Rhône-Alpes Rhône Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSIDAD COMPLUTENSE DE MADRID Spain Net EU contribution € 569 000,00 Address Avenida de seneca 2 28040 Madrid See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 EDUCELL PODJETJE ZA CELICNO BIOLOGI JO DOO Slovenia Net EU contribution € 293 350,00 Address Prevale 9 1236 Trzin See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Slovenija Zahodna Slovenija Osrednjeslovenska Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 ATRINEO AG Germany Net EU contribution € 236 225,00 Address Kaiserstr. 118 76133 Karlsruhe See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Baden-Württemberg Karlsruhe Karlsruhe, Stadtkreis Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 ACADEMISCH ZIEKENHUIS GRONINGEN Netherlands Net EU contribution € 405 000,00 Address Hanzeplein 1 9713 GZ Groningen See on map Region Noord-Nederland Groningen Overig Groningen Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 ANTHOGYR SAS France Net EU contribution € 170 000,00 Address Avenue andre lasquin 2237 74700 Sallanches See on map Region Auvergne-Rhône-Alpes Rhône-Alpes Haute-Savoie Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 GLANTREO LIMITED Ireland Net EU contribution € 247 375,00 Address Eri building lee road T23XE10 Cork See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Ireland Southern South-East Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 CROOM PRECISION TOOLING LIMITED Ireland Net EU contribution € 372 500,00 Address Garranroe patrickswell Limerick See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Ireland Southern Mid-West Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSITAET SIEGEN Germany Net EU contribution € 386 956,00 Address Adolf reichwein strasse 2a 57076 Siegen See on map Region Nordrhein-Westfalen Arnsberg Siegen-Wittgenstein Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,25
