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Novel biomaterials to prevent dental peri-implant infections

Objective

Peri-implant infections are a devastating complication of dental implants, occurring in approximately 20% of all patients, that can ultimately lead to implant instability and loss. Considering this high prevalence rate and the lack of predictive treatments in severe cases, prevention of peri-implantitis has become a major challenge in clinical dentistry.

NOMAD will develop innovative biomaterial approaches for dental implants, from TRL3 to TRL5. Various functionalised implant coatings for titanium and zirconia implant surfaces will reduce the risk of infection (and associated inflammation), improve soft-tissue sealing at the gum line, and promote osseointegration. A further innovation are multi-material crowns and abutments using additive manufacturing combined with grafting of nanotubes, enabling controlled release of prebiotic as well as antimicrobial compounds in response to bacterial adhesion at the onset of infection (i.e. smart conditional release). A combination of these approaches will be employed in the final product to provide a customisable, all-round solution focusing on crown, abutment and/or fixture for prevention of peri-implantitis.

Advanced in vitro testing using complex cell co-cultures in bioreactor systems, and biomechanical stability tests will enable selecting the most promising biomaterials for testing in relevant in vivo models. These results will enable rapid progression to first-in-human studies of new biomaterials after the project. A cost-benefit and regulatory analysis will be performed and an innovation management strategy will develop a roadmap for commercialisation.

The NOMAD consortium includes a major dental implant manufacturer, academic groups, SMEs working on biomaterials innovation and a specialist innovation company. The project is a major opportunity for enhancing EU competitiveness in biomaterials and inter-sector technology transfer.

Coordinator

KATHOLIEKE UNIVERSITEIT LEUVEN
Net EU contribution
€ 1 506 218,00
Address
Oude Markt 13
3000 Leuven
Belgium

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Region
Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00

Participants (11)

Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

HEALTH HOUSE
Belgium
Net EU contribution
€ 37 500,00
Address
Gaston Geenslaan 11 Gebouw B4
3001 Heverlee

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven
Activity type
Other
Other funding
€ 0,00
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
Net EU contribution
€ 451 203,75
Address
Rue Michel Ange 3
75794 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Other funding
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

ECOLE CENTRALE DE LYON
France
Net EU contribution
€ 32 891,25
Address
Avenue Guy De Collongue 36
69134 Ecully

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Region
Auvergne-Rhône-Alpes Rhône-Alpes Rhône
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
UNIVERSIDAD COMPLUTENSE DE MADRID
Spain
Net EU contribution
€ 569 000,00
Address
Avenida De Seneca 2
28040 Madrid

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Region
Comunidad de Madrid Comunidad de Madrid Madrid
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
EDUCELL PODJETJE ZA CELICNO BIOLOGI JO DOO
Slovenia
Net EU contribution
€ 293 350,00
Address
Prevale 9
1236 Trzin

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Slovenija Zahodna Slovenija Osrednjeslovenska
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
ATRINEO AG
Germany
Net EU contribution
€ 236 225,00
Address
Kaiserstr. 118
76133 Karlsruhe

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Baden-Württemberg Karlsruhe Karlsruhe, Stadtkreis
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
ACADEMISCH ZIEKENHUIS GRONINGEN
Netherlands
Net EU contribution
€ 405 000,00
Address
Hanzeplein 1
9713 GZ Groningen

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Region
Noord-Nederland Groningen Overig Groningen
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
ANTHOGYR SAS
France
Net EU contribution
€ 170 000,00
Address
Avenue Andre Lasquin 2237
74700 Sallanches

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Region
Auvergne-Rhône-Alpes Rhône-Alpes Haute-Savoie
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
GLANTREO LIMITED
Ireland
Net EU contribution
€ 247 375,00
Address
Eri Building Lee Road
T23XE10 Cork

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Ireland Southern South-East
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
CROOM PRECISION TOOLING LIMITED
Ireland
Net EU contribution
€ 372 500,00
Address
Garranroe Patrickswell
Limerick

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Ireland Southern Mid-West
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
UNIVERSITAET SIEGEN
Germany
Net EU contribution
€ 386 956,00
Address
Adolf Reichwein Strasse 2a
57076 Siegen

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Region
Nordrhein-Westfalen Arnsberg Siegen-Wittgenstein
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,25