Novel biomaterials to prevent dental peri-implant infections

Project Information

NOMAD

Grant agreement ID: 101091669

DOI

10.3030/101091669

EC signature date 1 December 2022

Start date 1 December 2022

End date 31 May 2027

Funded under

• Digital, Industry and Space

Total cost

€ 4 708 219,25

EU contribution

€ 4 708 219,00

Coordinated by

KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium

Periodic Reporting for period 2 - NOMAD (Novel biomaterials to prevent dental peri-implant infections)

Reporting period: 2024-06-01 to 2025-11-30

Summary of the context and overall objectives of the project

Despite the high success rate for dental implant procedures, a high number of patients develop peri-implant infections, which can ultimately lead to implant instability and bone loss. Microorganisms sticking to implant surface and forming recalcitrant biofilms are a particular point of concern. NOMAD is a EU-funded research and innovation collaborative project aimed at developing the next generation of dental implants that can prevent peri-implant diseases, consequently improving the long-term success of implants while simultaneously reducing the socio-economic burden associated with these diseases in Europe. To tackle these pressing clinical challenges, NOMAD will implement a range of biomaterial innovations across different components of dental implants (including implant fixture, abutment, and restoration). These innovations will involve modifying the current titanium (Ti) implants and emerging zirconia (ZrO2) implants with materials designed to reduce the risk of infection (and associated inflammation), improve soft-tissue sealing at the gum line, and promote osseointegration.

Work performed from the beginning of the project to the end of the period covered by the report and main results achieved so far

In NOMAD, titanium and zirconia have been established as the main candidate materials for dental implants, with various surface modification strategies developed to enhance their biological and mechanical performance. WP1 focused on the design and optimization of biological coatings, while WP2 implemented smart release concepts for antimicrobial agents. A standardized workflow for sample sterilization has been set up, and samples have been evaluated for biomechanical stability according to relevant ISO standards to ensure durability during implantation and long-term use. Cytotoxicity evaluations have been completed, and samples have also been tested for antimicrobial activity and soft tissue regenerative potential, with results reported accordingly. Based on these assessments, the final candidates for in vivo testing have been selected and documented. Preparations are underway to scale up production and generate preclinical efficacy data, while a detailed cost-benefit, regulatory, and technology transfer analysis supports future commercialization of the new dental implant materials.

Progress beyond the state of the art and expected potential impact (including the socio-economic impact and the wider societal implications of the project so far)

At month 36, NOMAD has advanced beyond the state of the art by demonstrating fully functionalized titanium and zirconia surfaces with combined osseointegration-promoting, soft-tissue sealing, and antimicrobial/anti-biofilm properties. Cytotoxicity, antimicrobial activity, and soft tissue regenerative potential of the developed surfaces have been thoroughly evaluated, and the final candidates for in vivo testing have been selected. Comprehensive biomechanical testing, including sterilization resistance and durability under implantation-relevant forces, confirms the robustness and safety of the materials. The project has generated new insights into multifunctional surface design and has developed scalable workflows for surface functionalization, moving closer to preclinical validation. Market and IP analyses, regulatory assessments, and cost-benefit studies are supporting strategies for technology transfer and commercialization, while potential applications beyond dental implants are being actively explored to maximize impact. Dissemination activities continue to promote the innovative nature of the NOMAD approach.