Development of a multifunctional biomaterial patch for buccal delivery of peptide-analogue treatments

Project Information

BUCCAL-PEP

Grant agreement ID: 101091765

DOI

10.3030/101091765

EC signature date 18 November 2022

Start date 1 January 2023

End date 31 December 2026

Funded under

• Digital, Industry and Space

Total cost

€ 3 986 438,75

EU contribution

€ 3 971 426,50

Coordinated by

UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Ireland

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Conference proceedings (9)

Non-injected GLP-1 analogue administration : self-nanoemulsification with hydrophobic ion pairing.

Author(s): Ijaz, M.,& Brayden, D. J.
Publisher: 5th European Pharmaceutical Conference, Porto

Dissolvable microneedle-based mucoadhesive buccal patch for anti-cancer peptide delivery

Author(s): Malhotra, S., Lijnse, T, O’Cearbhaill, E, & Brayden, D. J.
Publisher: TERMIS, Freiberg, Germany

Utilizing bilosomes for buccal peptide delivery

Author(s): Eleftheria Pantazoglou; Matteo Tollemeto; Mathilde Sophie Felding; Leticia Hosta-Rigau; Jette Jacobsen; Line Hagner Nielsen
Published in: 2024
Publisher: CRS Bologna.

Design of a bilayer film for buccal delivery of GLP-1 peptide receptor agonist for the treatment of Type 2 Diabetes Mellitus

Author(s): Karki, S. Malhotra, Ijaz, M., O'Cearbhaill, E., & Brayden, D. J.
Publisher: 5th European Pharmaceutical Conference, Porto

Non-covalent lipidation and self nano-emulsions: ex-vivo porcine buccal mucosal permeation of a GLP-1RA peptide

Author(s): Ijaz, M., Karki, S., & Brayden, D. J.
Publisher: ...

Buccal peptide delivery using polymeric films: Exploring the role of glycerol.

Author(s): Eleftheria Pantazoglou; Matteo Tollemeto; Nazanin Zanjanizadeh Ezazi; Tien-Jen Chang; Leticia Hosta-Rigau; Jette Jacobsen; Line Hagner Nielsen
Publisher: Austria Centre Vienna

Hydrophobic ion pair complexes of a GLP-1 peptide receptor agonist analogue designed to increase peptide permeability across the buccal epithelium.

Author(s): Ijaz, M. & Brayden, D.J.
Published in: 2024
Publisher: CRS Bologna

Designing dissolvable microneedle patches for buccal peptide administration

Author(s): Malhotra, S., Lijnse, T., O’ Cearbhaill,E., & Brayden, D. J.
Publisher: 5th European Pharmaceutical Conference, Porto

Enhancing transmucosal uptake of a GLP-1 analogue: combining ionic lipidation and Self-Nanoemulsifying Drug Delivery (SNEDDS) systems.

Author(s): Ijaz, M., Karki, S., & Brayden, D. J.
Publisher: xx

Peer reviewed articles (6)

Real-time monitoring and characterization of thin film drug delivery systems using optical coherence tomography

Author(s): Johan Barfoed, Eleftheria Pantazoglou, Gavrielle R. Untracht, Nazanin Zanjanizadeh Ezazi, Line Hagner Nielsen, Peter E. Andersen
Published in: International Journal of Pharmaceutics, Issue 685, 2026, ISSN 0378-5173
Publisher: Elsevier BV
DOI: 10.1016/J.IJPHARM.2025.126201

Boosting buccal drug absorption: Mechanistic insights into bilosome-mediated delivery

Author(s): Eleftheria Pantazoglou, Scarlett Zeiringer, Matteo Tollemeto, Nazanin Zanjanizadeh Ezazi, Zhongyang Zhang, Leticia Hosta-Rigau, Jette Jacobsen, Ramona Jeitler, Eva Roblegg, Line Hagner Nielsen
Published in: International Journal of Pharmaceutics: X, Issue 10, 2025, ISSN 2590-1567
Publisher: Elsevier BV
DOI: 10.1016/J.IJPX.2025.100444

Devices to overcome the buccal mucosal barrier to administer therapeutic peptides

Author(s): Sahil Malhotra, Thomas Lijnse, Eoin O’ Cearbhaill, David J. Brayden
Published in: Advanced Drug Delivery Reviews, Issue 220, 2025, ISSN 0169-409X
Publisher: Elsevier BV
DOI: 10.1016/J.ADDR.2025.115572

Buccal delivery of small molecules and biologics: Of mucoadhesive polymers, films, and nanoparticles - An update

Author(s): Varsha V Nair , Pablo Cabrera , Constanza Ramírez-Lecaros , Miguel O Jara, David J Brayden, Javier O Morales
Published in: International Journal of Pharmaceutics, ISSN 0378-5173
Publisher: Elsevier
DOI: 10.1016/J.IJPHARM.2023.122789

Oromucosal films for peptide delivery: formulation strategies using permeation enhancers and polymers

Author(s): Sandeep Karki, Sahil Malhotra, Muhammad Ijaz, Eoin D. O’Cearbhaill, Line Hagner Nielsen, David J. Brayden
Published in: Drug Delivery and Translational Research, 2025, ISSN 2190-393X
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/S13346-025-02004-6

Safety of surfactant excipients in oral drug formulations

Author(s): Sam Maher, Caroline Geoghegan, David J. Brayden
Published in: Advanced Drug Delivery Reviews, ISSN 1872-8294
Publisher: Elsevier
DOI: 10.1016/J.ADDR.2023.115086