CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.
Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .
Resultado final
Both graphene and graphene oxide (GO)materials will be synthesised and provided. Graphene will be obtained by the electrochemical exfoliation of graphite throughthe application of a voltage to graphite foils in an aqueous solution of sulphate salts. The materials will then becollected, purified, and studied both in suspension and in powder form. GO will be obtained by the chemicaloxidation of graphite in water following the well-known modified Hummers method. The oxidation process canbe modified in several parts through the DoE to tune the final product characteristics. Both graphene and GOmaterials can undergo a final step of sonication. GFMs with characteristics of interest from a morphological andbiological point of view will be functionalized with different chemical groups, such as amine (-NH2) andcarboxylic acid (-COOH) groups, by treating the GFMs under specific conditions.
Report on measurement procedures developed for the accurate chemical analysis of GFMs, including correlation with the morphological analysis in T2.1 (se abrirá en una nueva ventana)Reporting the approaches to correlate the chemical characteristics, as determined by the high-resolution methods Auger electron microscopy (BAM), ToF-SIMS (BAM), and TEM/EDS/EELS (UOxf, BAM), with the bulk material chemistry, using SEM/EDS (BAM) and Raman (Hay, UniTo), and local morphology and structure, via SEM, TEM, SAED, and XRD (by BAM, UOxf, Hay and UniTo). The generated chemical data will be selectively prepared for WP4, and further application for the commercial materials in WP3 for multi-scale descriptors.
Communication and dissemination plan (se abrirá en una nueva ventana)A Communication and Dissemination plan, focusing on its implementation and monitoring of the project results. Developed and presented in M3, the plan will be detailed and flexible, being periodically updated and deployed along the project life cycle (M15, M30 and M42). The plan will include target audiences, which key messages need to be shared, the communication channels that will be used, and the timeline for the various communication activities. Project results will be efficiently communicated to all stakeholders paying special attention to regulatory agencies, standardisation and test validation organizations, industry (including instrument manufacturers, NM manufacturers, and industry associations), academia, research labs, and the general public.
Set-up of Management Framework and Grant agreement (se abrirá en una nueva ventana)A shared file server will be set up on the project website for exchanging documents between all project partners and for preparing templates and tools for documentation. A kick-off meeting will be organized in month 1 to inform all partners (General Assembly, GA) about their roles, responsibilities, rights and obligations, along with information regarding structures, procedures, templates and tools for reporting, dissemination, and data filing. The Project Management Board will act as the supervisory body for the execution of the project reporting to the GA, and the coordinator - the legal entity acting as the intermediary between the Parties and the Funding Authority. The project Steering Board (SB) (cf. below), which will consist of all WP leaders, will meet at the same time and agree on a Quality Management Plan (QMP), to be prepared by the Coordinator, which will define clear criteria for fulfilment, timing, and roles/responsibilities for all Deliverables and Milestones showing who will be the main responsible partner and who will collaborate.
Guidance on hazard and toxicity tests developed for GFMs. Tiered approach to biological/safety characterisation of GFMs. (se abrirá en una nueva ventana)Development of tiered strategy for correlative GFM biological/safety characterisation will be elaborated. The tiered bio-testing approach will integrate biological methods at different levels of biological complexity (molecules done by UL, UoB, cells in vitro done by UL, NWU and WFSR), organoid model (WFSR), environmentally relevant test with unicellularorganism done by UL) and assays with different throughput levels, measured endpoints, labelling needs, potentials for correlating imaging/non-imaging techniques with physico-chemical characterization, and levels of practicality/simplicity to perform (on the spot or by using advanced imaging techniques).
Report on measurement procedures developed for the accurate analysis of the morphology and structure of GFMs (se abrirá en una nueva ventana)The three classes of laboratory-scale GFMs (graphene, GO, and functionalized graphene) synthesised by UniTo will constitute the base material for systematic morphological characterisation and method development in this task. High-resolution SEM, STEM-in-SEM, and AFM will be used by BAM and (HR)TEM by UOxf to precisely characterise the morphology of the GFMs from WP1. In the first phase (M2-6), sample preparation procedures (powders and liquid suspension) will be developed or available knowledge optimised to obtain homogeneous and accurate depositions of the GFMs as individual objects on a suited substrate.Correlative approaches, such as with SEM in different detection modes (InLens, transmission mode), but also with TEM, SAED, AFM, and imaging ellipsometry, will be developed by both BAM and UOxf. Descriptive microscopy procedures to quickly andapproximately indicate the size and shape of GFMs, in addition to accurate and sophisticated approaches, will be elaborated jointly by BAM and UniTo. The morphological data will be prepared for WP4 (by EwC).
Quality Management Plan (se abrirá en una nueva ventana)The coordination team will monitor scientific task implementation across theproject and, if necessary, take mitigating actions to keep the project in line with timing and budget. This task includes the following activities: elaboration of the Consortium Agreement, supervision of financial, legal, ethical, and administrative management, coordination and revision of the performance, timing, and quality of the technical work progress, monitoring the members’ work execution according to the project planning, organization and chairing of the consortium meetings, and periodic reporting with contributions from the rest of the participants. A secure server will be set up to share administrative documents, templates for documentation, and procedural guides. The server will later contain reports, minutes, and presentations from meetings. UL will give guidance and act as a ‘helpdesk’ for all matters regarding organization, guidelines, or agreements. The Coordinator will handle the day-to-day work in collaboration as one joint Management Office (MGTO).
Literature search to identify gaps (se abrirá en una nueva ventana)The up-to-date description of the technical specifications, guidelines, and best practices published by ISO and OECD to identify existing gaps. Communication with standard setting organisations
Contribution of the parameters affecting the synthesis of graphene materials (se abrirá en una nueva ventana)Both graphene and graphene oxide (GO) materials will be synthesised. Graphene will be obtained by the electrochemical exfoliation of graphite through the application of a voltage to graphite foils in an aqueous solution of sulphate salts. The materials will then be collected, purified, and studied both in suspension and in powder form. GO will be obtained by the chemical oxidation of graphite in water following the well-known modified Hummers method. The oxidation process can be modified in several parts through the DoE to tune the final product characteristics. Both graphene and GO materials can undergo a final step of sonication. GFMs with characteristics of interest from a morphological and biological point of view will be functionalized with different chemical groups, such as amine (-NH2) and carboxylic acid (-COOH) groups, by treating the GFMs under specific conditions.
ACCORDs will set a Knowledge Portal contining the protocols and data used in ACCORDs activities supported by the developed knowledge infrastructure, including extraction, collection and curation of heterogeneous data originating from various sources, and organising them into machine-readable, linked, and harmonized digital formats. Priority datasets will include characterisation, toxicological, and physico-chemical data on nanomaterials. All resources and services will be made available through an ACCORDs knowledge sharing web portal. Protocol templates will be developed for all experimental methods so that each new dataset generated on the project will be uploadedaccompanied by a linked versioned protocol, supporting the eventual provision of a final documented SOP.
ACCORDs Workflow system for characterisation, analysis, and reporting (se abrirá en una nueva ventana)Implementation of the ACCORDs e-platform as a toolbox of integrated user-friendly web-based applications. Workflows will include the preparation of reportinginformation satisfying the draft industrial and regulatory guidance information requirements developed by WP5. The various methods and approaches developed within the project will be implemented as web services and will be interlinked to produce the full integrated ACCORDs framework for guiding and supporting the end-usersthroughout the entire process. State-of-the-art IT tools for deployment of distributed applications (Docker, Kubernetes) will be used to ensure sustainability and enable flexibility and efficient management of the various microservices which will be updated and extended to address needed data analysis and modelling requirements defined in WPs 1-3, 5.
ACCORDs Image Analysis Methods and Software (se abrirá en una nueva ventana)Image Analysis methods will be delivered applicable for the management and processing of image data generated by the characterisation methods. Feature extraction algorithms will be developed for the automatic extraction of features from images. Machine learning and AI algorithms will be applied to feature sets supporting the development of models for characterising and classifying the graphene materials studied. We will include the evaluation of learning methods generating interpretable results that can be evaluated by experts.
To structure the data management in ACCORDs, a data management plan (DMP) will be put in place according to the guidelines on data management in the Horizon Europe program. User requirements and use cases on data, including both data generators and downstream data consumers, will be defined and documented and provide a basis for the development of a systems design and technical implementation plan for the resources developed (T4.2-4).
Publicaciones
Autores:
Bashiru Ibrahim; Taiwo Hassan Akere; Pankti Dhumal; Eugenia Valsami-Jones; Swaroop Chakraborty
Publicado en:
Environmental Science: Nano, 2025, ISSN 2051-8161
Editor:
Royal Society of Chemistry
DOI:
10.1039/D4EN01173B
Autores:
Flemming R. Cassee; Eric A.J. Bleeker; Cyrille Durand; Thomas Exner; Andreas Falk; Danail Hristozov; Sabine Hofer; Norbert Hofstätter; Steffi Friedrichs; Elisabeth Heunisch; Martin Himly; Penny Nymark; Anna Pohl; Lya G. Soeteman-Hernández; Blanca Suarez-Merino; Eugenia Valsami-Jones; Monique Groenewold
Publicado en:
Computational and Structural Biotechnology Journal, 2024, ISSN 2001-0370
Editor:
Elsevier
DOI:
10.5281/ZENODO.10876679
Autores:
Paul Mrkwitschka, Mario Sahre, Elena Corrao, Francesco Pellegrino, Vasile-Dan Hodoroaba
Publicado en:
Microscopy and Microanalysis, Edición 31, 2025, ISSN 1431-9276
Editor:
Oxford University Press (OUP)
DOI:
10.1093/MAM/OZAF048.219
Autores:
Loay Akmal Madbouly, Paul Mrkwitschka, Jörg Manfred Stockmann, Elliot Jones, Jörg Radnik, Vasile‐Dan Hodoroaba
Publicado en:
Surface and Interface Analysis, Edición 57, 2025, ISSN 0142-2421
Editor:
Wiley
DOI:
10.1002/SIA.7386
Autores:
Rossi, Andrea; Alladio, Eugenio; Drobne, Damjana; Hodoroaba, Vasile-Dan; Jurkschat, Kerstin; Kononenko, Veno; Madbouly, Loay Akmal; Mrkwitschka, Paul; Novak, Sara; Radnik, Jörg; Saje, Špela; Santalucia, Rosangela; Sordello, Fabrizio; Pellegrino, Francesco
Publicado en:
Scientific Reports, 2024, ISSN 2045-2322
Editor:
Nature Portfolio
DOI:
10.1038/S41598-024-73606-2
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