The ARACNE project aims to promote and preserve Europe's silk heritage through Cultural and Creative Industries (CCIs). The EU recognizes the importance of protecting cultural heritage as a valuable resource for social cohesion, economic growth, and promoting a common European identity. Despite the decline in raw silk production in the EU, silk textiles remain in demand globally and contribute to EU textile exports. On the other hand, there is a wide range of applications for silk other than textiles, which are currently the subject of research by many companies and organisations. ARACNE seeks to establish a Silk Innovation Ecosystem, involving academia, industry, and civil society to promote research and innovation, a ‘human networks that can generate extraordinary creativity and output on a sustainable bases’. Nowadays, the European silk industry is facing challenges due to dependence on Chinese silk production, rising international silk prices, as well as the risk of losing a significant cultural heritage associated with silk production and concerns about sustainability. Maintaining and enhancing the resilience of the European silk industry is crucial for the future. By integrating cultural heritage, scientific innovation and artistic creativity (social and humanities disciplines), ARACNE aims to revitalise the European silk agricultural self-production and industrial processing also through digital tools and non-traditional tourism experiences. The revitalisation of the European silk industry not only promotes economic growth, but also serves as a cultural rebalancing against the dominant narrative of modern Silk Road trade politics, potentially establishing a new cultural itinerary across the diverse European countries.