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CORDIS - Résultats de la recherche de l’UE
CORDIS

Methodologies for Assessing the Real Costs to Health of Environmental Stressors

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Final assessment of exposures and unit prices for nitrate in drinking water in case study areas (s’ouvre dans une nouvelle fenêtre)

Detailed health impact assessment including local scale resolution nitrogen leaching modeling for two selected case areas (Jutland/DK groundwater and Zelivka/CR surface water) will be performed with the SWAT/SWAT+ model for both case studies, while for the groundwater case study also mapping derived from a high-resolution DK-model will be used.When linked with health effects exposure-response functions (from WP2) and valuation of mortality/morbidity/disability (from WP3) this will allow for estimations of the external costs per unit of nitrogen.

Selected air pollution exposure-response functions with baseline incidences for EVA (s’ouvre dans une nouvelle fenêtre)

For air pollution we give priority to the following morbidity impacts: asthma incidence, lung cancer and COPD, e.g. for O3, PM2.5 and NO2. While these health endpoints are frequently included in the integrated assessment models of air pollution (based on the 2013 WHO recommendations), the specific exposure-response functions applied are relatively dated and need to be reevaluated based on the available systematic reviews of the health literature. However, considering COPD as well as asthma we will provide an update, to reflect results from the ELAPSE project and other studies published in recent years. Additionally, we will address a series of ‘new’ outcomes from air pollution identified in the health literature (i.e. diabetes, cognitive disorders/dementia, Parkinson’s disease, low birth weight, depression) to investigate whether evidence from the recently published systematic reviews is sufficiently robust (considering possible confounders) to allow for inclusion in impact assessments in a European setting, and what the relevant exposure-response functions are. The metrics applied for air pollution will mainly be primary/secondary PM2.5, NO2 and O3 with epidemiological studies based on two-pollutant models warranting the strongest interest in order to avoid any double-counting of the health impacts identified. Considering the availability of the recently published systematic review on air pollution mortality by WHO (including cardiovascular effects), we see limited value in replication and will from this review extract exposure-response functions relevant to European conditions.The exposure-response functions identified will hinge on the population sub-groups identified in epidemiological studies; we will distinguish between acute and chronic effects, the latter resulting from exposure over several years. Considering the findings of ELAPSE, careful attention will be paid to possible non-linearities of exposure-response functions, especially associated with low-level exposures. Critical data gaps will be identified as regards environment and health risk factors.

Final assessment of exposures and unit prices for air pollution in case study areas (s’ouvre dans une nouvelle fenêtre)

Detailed high-resolution air pollution modeling for three selected case study areas (Øresund, Catalonia, and Estonia) at 1 km x 1 km resolution will be performed with the UBM model (Øresund), the Monarch model (Catalonia) and the AirViro/MATCH model (Estonia). These models have been designed for high performance in the specific regions and includes detailed local emission inventories. Following the approach detailed in Task 5.4, sector wise simulations will be made to assess impacts of individual emission sectors on air pollution levels. The resulting high resolution air pollution concentration levels and sector emission totals will be used as input to the updated EVA system and the output is high-resolution health externality data and unit prices for the case study areas.

Spatial health risk map of Europe with indicators of air pollution risks to the general public (s’ouvre dans une nouvelle fenêtre)

Concise policy briefs with infographics will be developed for each of the main deliverables of WP3-6.

Selected drinking water nitrate exposure-response functions with baseline incidences (s’ouvre dans une nouvelle fenêtre)

For drinking water nitrate, we give priority to two morbidity endpoints: besides cancers related to gastro-intestinal sites also impacts on infants in terms of adverse birth outcomes and methemoglobinemia. While for the gastro intestinal health endpoint we will rely on findings from recent systematic review, our novel systematic review of impacts on infants aims to identify whether these could be included with a high degree of certainty. The WP will also present figures for the possible impacts in areas where there is a scarcity of studies available in the literature, hence pointing to research needs and data gaps that should warrant further interest. The exposure-response functions identified will hinge on the population sub-groups identified in epidemiological studies; we will distinguish between acute and chronic effects, the latter resulting from exposure over several years. Attention will be paid to possible non-linearities of exposure-response functions, especially associated with low-level exposures. Critical data gaps will be identified as regards environment and health risk factors.

Two policy briefs with infographics (s’ouvre dans une nouvelle fenêtre)

Concise policy briefs with infographics will be developed for each of the main deliverables of WP3-6.

Cluster brochure (s’ouvre dans une nouvelle fenêtre)

Cluster brochure (M12)

Cluster newsletter 1 (s’ouvre dans une nouvelle fenêtre)

Cluster newsletter 1 (M18)

Website launch (s’ouvre dans une nouvelle fenêtre)

A project website will be designed and developed applying the MARCHES visual identity.The website will be a main entry point to general information on the project, with link to open access publications and the Researchgate.net page. Core scientific results will be summarized at the website. The website language will be English.

Policy brief 1 (s’ouvre dans une nouvelle fenêtre)

Cluster Policy brief 1 (M18)

Cluster web portal and visual identity (s’ouvre dans une nouvelle fenêtre)

Cluster web portal and visual identity (M9)

Cluster Data Management Strategy (s’ouvre dans une nouvelle fenêtre)

Cluster Data Management Strategy (M12)

Data Management Plan (s’ouvre dans une nouvelle fenêtre)

The Data Management Plan (DMP) (DL1.1) (M6) will provide operating procedures to fulfil three main objectives; a) a harmonized set of heterogenous data (health, geographical, atmospheric, socio-economic) across the different countries and case study areas respectively, including for the delivery of metadata b) quality control with data processing and c) data indexing and publication with controlled data sharing mechanisms, including persistent identifiers (PID). The plan will ensure that the data can be found, accessed, interoperated and reused in accordance with FAIR principles. The DeiC (Danish e-infrastructure Cooperation) webtool DMPonline (https://dmponline.deic.dk/plans) will be used for setting up and disseminating a data management plan consistent with the Horizon DMP template. The DMP of MARCHES will be publicly available on the DeiC platform. Data will be stored for public assess at the platform of Zenodo (http://zenodo.org). The platform allows results from projects funded under Horizon Europe to be stored, shared and showcased (both data and publications) and licensed under Creative Commons. A Data Manager (Dr. Steen Solvang Jensen of AU) will be appointed to oversee the establishment, updating and implementation of the data management plan.

Publications

Air pollution exposure and inflammatory bowel disease: a systematic literature review of epidemiological and mechanistic studies (s’ouvre dans une nouvelle fenêtre)

Auteurs: Henrik Olstrup; Hani A. S. Mohamed; Julie Honoré; Jörg Schullehner; Jörg Schullehner; Torben Sigsgaard; Torben Sigsgaard; Bertil Forsberg; Anna Oudin; Anna Oudin
Publié dans: Frontiers in Environmental Health, 2024, ISSN 2813-558X
Éditeur: Frontiers Media S.A.
DOI: 10.3389/FENVH.2024.1463016

The Impact of Socioeconomic Factors on Long-Term Mortality Associated With Exposure to PM2.5: A Systematic Literature Review and Meta-Analysis (s’ouvre dans une nouvelle fenêtre)

Auteurs: Henrik Olstrup, Wasif Raza, Johan Nilsson Sommar, Hans Orru
Publié dans: Public Health Reviews, Numéro 46, 2025, ISSN 2107-6952
Éditeur: Frontiers Media SA
DOI: 10.3389/PHRS.2025.1607290

Prenatal Exposure to Nitrate in Drinking Water and Adverse Health Outcomes in the Offspring: a Review of Current Epidemiological Research (s’ouvre dans une nouvelle fenêtre)

Auteurs: Clemmensen, Schullehner et al
Publié dans: Current Environmental Health Reports, Numéro 10, 2023, ISSN 2196-5412
Éditeur: Springer
DOI: 10.1007/s40572-023-00404-9

A Review of the Evidence of the Toxicity of Chemical Substances Included in the European Union Ambient Air Quality and Drinking Water Directives: Perspectives for Health Impact Assessments (s’ouvre dans une nouvelle fenêtre)

Auteurs: Hans Orru
Publié dans: Environment & Health, Numéro Vol 3/Numéro 9, ISSN 2833-8278
Éditeur: American Chemical Society
DOI: 10.1021/ENVHEALTH.4C00277

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