Elucidation of risk factors and health determinants associated with PROGRESSION of Monoclonal Gammopathies to Multiple Myeloma

Información del proyecto

ELMUMY

Identificador del acuerdo de subvención: 101097094

DOI

10.3030/101097094

Fecha de la firma de la CE 1 Diciembre 2022

Fecha de inicio 1 Enero 2023

Fecha de finalización 31 Diciembre 2026

Financiado con arreglo a

• Health

Coste total

€ 9 951 078,19

Aportación de la UE

€ 9 951 078,19

Coordinado por

ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON
Greece

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (6)

Common work plan for scientific collaboration under the ‘Understanding’ cluster

Common work plan for scientific collaboration under the ‘Understanding’ cluster.

Multiannual Dissemination Strategy

Multiannual Dissemination Strategy. A detailed dissemination plan will be communicated to all partners at the onset of the project.

Conclusions of common annual meeting of the ‘Understanding’ cluster and policy brief formulating recommendations based on the research and innovation strand of the ‘Understanding’ annual cluster meeting, v2.
Federated Database System and Data Warehouse

Federated Database System and Data Warehouse. A Report on the Schema, the Data types and the Information flow regarding the Federated Database System (FDBS) and Data Warehouse which will transparently map the existing multiple autonomous database/repository systems into a single federated database.

Data Management Plan

Data Management Plan. A Report describing a detailed Data Management Plan (DMP) will be elaborated early in the project to ensure high quality data management, optimal use and longevity complying with the FAIR principles.

Conclusions of common annual meeting of the ‘Understanding’ cluster and policy brief formulating recommendations based on the research and innovation strand of the ‘Understanding’ annual cluster meeting.

Websites, patent fillings, videos etc. (2)

Common video and a common cluster brochure

Common video and a common cluster brochure will be created with the active contribution of ELMUMY.

Project Web presence (Website and Social Media)

Project Web presence (Website and Social Media). A project website with a public and restricted area and social media channels will be created.

Publicaciones

Peer reviewed articles (35)

Circulating tumor cells by Next Generation Flow Cytometry as a new prognostic biomarker for patients with asymptomatic monoclonal gammopathies

Autores: Efstathios Kastritis, Panagiotis Malandrakis, Ioannis V. Kostopoulos, Ioannis Ntanasis-Stathopoulos, Irene Solia, Foteini Theodorakakou, Vasiliki Spiliopoulou, Despina Fotiou, Magdalini Migkou, Nikolaos Kanellias, Evangelos Eleutherakis-Papaiakovou, Konstantina Taouxi, Alexandra Papadimou, Christine-Ivy Liacos, Maria Gavriatopoulou, Ourania Tsitsilonis, Evangelos Terpos, Meletios-Athanasios Dimopoulos
Publicado en: Blood Cancer Journal, Edición 15, 2025, ISSN 2044-5385
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S41408-025-01369-8

Minimally Invasive Assessment of Peripheral Residual Disease During Maintenance or Observation in Transplant-Eligible Patients With Multiple Myeloma

Autores: Marta Lasa, Laura Notarfranchi, Cristina Agullo, Carmen Gonzalez, Sergio Castro, Jose J. Perez, Leire Burgos, Camila Guerrero, Maria Jose Calasanz, Juan Flores-Montero, Albert Oriol, Joan Bargay, Rafael Rios, Valentin Cabañas, Carmen Cabrera, Rafael Martinez-Martinez, Cristina Encinas, Felipe De Arriba, Miguel-Teodoro Hernandez, Luis Palomera, Alberto Orfao, Joaquin Martinez-Lopez, Maria-Victoria Mateos, Jesus San-Miguel, Juan Jose Lahuerta, Laura Rosiñol, Joan Blade, Maria Teresa Cedena, Noemi Puig, Bruno Paiva, null null, María Casanova, Carmen Couto, Estrella Carrillo, Esther González, Ana Pilar González, Antonia Sampol, Alexia Suárez, Carmen Montes, Mª del Carmen Calle, Luís Felipe Casado, Dunia de Miguel, Ángela Ibáñez, Jorge Labrador, Aránzazu García, Fernando Escalante, Carlos Aguilar, Lourdes Escoda, Ana María Sureda, Cristina Motlló, Yolanda González, Eugenia Monreal, Juan Alfonso Soler, Miquel Granell, Elena Cabezudo, Josep Mª Martí, Antonio García, Mercedes Gironella, Ana Dios, José Ángel Méndez, Marta Sonia González, Mª José Nájera, Francisco Javier Peñalver, Pilar Bravo, José Ángel Hernández, Jaime Pérez de Oteyza, Rebeca Iglesias del Barrio, Ana López de la Guía, Adrián Alegre, Isabel Krsnik, Elena Ruíz, Mª Jesús Blanchard, Belén Íñigo, Eugenio Giménez, Rosalía Riaza, Elena Prieto, Marta Romera, Jose Mª Moraleda, Felipe Prósper, Jose Mª Arguiñano, María Puente, Xabier Gutiérrez, Ana Isabel Teruel, Paz Rivas, Isidro Jarque, Ángel Fernández, Amparo Santamaría, Carmen Martínez
Publicado en: Journal of Clinical Oncology, Edición 43, 2025, ISSN 0732-183X
Editor: American Society of Clinical Oncology (ASCO)
DOI: 10.1200/JCO.24.00635

Patterns of progression among 427 patients with smoldering myeloma diagnosed after 2014: importance of monitoring

Autores: Efstathios Kastritis, Irene Solia, Panagiotis Malandrakis, Foteini Theodorakakou, Ioannis Ntanasis-Stathopoulos, Nikolaos Kanellias, Despina Fotiou, Magdalini Migkou, Evangelos Eleutherakis-Papaiakovou, Vassiliki Spiliopoulou, Nikoleta Kokkali, Asimina Papanikolaou, Stavroula Giannouli, Maria Gavriatopoulou, Evangelos Terpos, Meletios A. Dimopoulos
Publicado en: Blood Advances, Edición 9, 2025, ISSN 2473-9529
Editor: American Society of Hematology
DOI: 10.1182/BLOODADVANCES.2025016083

<i>FCGR3A</i> F158V alleles frequency differs in multiple myeloma patients from healthy population

Autores: Michaël Constantinides, Nicolas Robert, Caroline Multrier, Loïs Coënon, Mauricio Campos-Mora, Carine Jacquard, Fei Gao, Sara Zemiti, Jessy Presumey, Guillaume Cartron, Jérome Moreaux, Martin Villalba
Publicado en: OncoImmunology, Edición 13, 2024, ISSN 2162-402X
Editor: Taylor & Francis Online
DOI: 10.1080/2162402X.2024.2388306

Stage-specific gene pair ratios highlight genes and mechanisms related to presymptomatic and symptomatic Multiple Myeloma

Autores: Grigoris Georgiou; George Minadakis; Nestoras Karathanasis; Kyriaki Savva; Efi Athieniti; Marilena M Bourdakou; George M Spyrou
Publicado en: Computational and Structural Biotechnology Journal, 2024, ISSN 2001-0370
Editor: Elsevier B.V.
DOI: 10.1101/2024.11.04.621824

Cancers

Autores: Nestoras Karathanasis; George M. Spyrou
Publicado en: Cancers, 2025, ISSN 2072-6694
Editor: MDPI
DOI: 10.3390/CANCERS17020332

EZH2 targeting induces CD38 upregulation and response to anti-CD38 immunotherapies in multiple myeloma

Autores: Djamila Chemlal, Emmanuel Varlet, Amelie Machura, Sara Ovejero, Guilhem Requirand, Nicolas Robert,.....,Angélique Bruyes, Hugues De Boussac and Jerome Moreaux
Publicado en: Leukemia, ISSN 1476-5551
Editor: Nature.com
DOI: 10.1038/S41375-023-01983-0

ciRS-7 circular RNA overexpression in plasma cells is a promising molecular biomarker of unfavorable prognosis in multiple myeloma

Autores: Maria Papatsirou, Christos K Kontos, Ioannis Ntanasis-Stathopoulos, Panagiotis Malandrakis, Foteini Theodorakakou, Christine-Ivy Liacos, Nefeli Mavrianou-Koutsoukou, ......., Efstathios Kastritis, Meletios A Dimopoulos, Andreas Scorilas, Evangelos Terpos
Publicado en: EJHaem., ISSN 2688-6146
Editor: Wiley
DOI: 10.1002/JHA2.903

Targeting transcription-replication conflicts using G-quadruplexes stabilizers in multiple myeloma

Autores: Dutrieux, Laure; Ovejero, Sara; Guillemin, Antoine; Zellagui, Miss Leriem; de Bruyne, Elke; Muylaert, Catharina; van Hemelrijck, Lien; Lin, Yea-Lih; Loughran, Elle; Choquet, Armelle; Magat, Talha; Bouchouika, Soumya; Bret, Caroline; Requirand, Guilhem; Robert, Nicolas; Vincent, Laure; Cartron, Guillaume; Herbaux, Charles; Rodriguez, Raphaël; Cogné, Michel; Rivals, Eric; Andrau, Jean-Christophe; David, Alexandre; Pasero, Philippe; Moreaux, Jérôme
Publicado en: Blood Neoplasia, 2025, ISSN 2950-3280
Editor: Elsevier
DOI: 10.1016/J.BNEO.2025.100072

Blood Cancer Journal

Autores: Konstantinos Soureas; Panagiotis Malandrakis; Maria-Alexandra Papadimitriou; Christos Minopoulos; Ioannis Ntanasis-Stathopoulos; Christine-Ivy Liacos; Maria Gavriatopoulou; Efstathios Kastritis; Meletios-Athanasios Dimopoulos; Andreas Scorilas; Margaritis Avgeris; Evangelos Terpos
Publicado en: Blood Cancer Journal, 2025, ISSN 2044-5385
Editor: Springer Nature
DOI: 10.1038/S41408-025-01248-2

Cellular Oncology

Autores: Caroline Bret, Fabienne Desmots-Loyer, Jérôme Moreaux, Thierry Fest
Publicado en: Cellular Oncology, Edición 48, 2025, ISSN 2211-3428
Editor: Springer Verlag
DOI: 10.1007/S13402-024-00973-3

Clinical proteomics, quo vadis?

Autores: Mischak, Harald; Schanstra, Joost P.; Vlahou, Antonia; Beige, Joachim
Publicado en: PROTEOMICS, 2024, ISSN 1615-9861
Editor: John Wiley & Sons
DOI: 10.1002/PMIC.202400346

<i>FCGR3A</i> F158V alleles frequency differs in multiple myeloma patients from healthy population

Autores: Michaël Constantinides, Nicolas Robert, Caroline Multrier, Loïs Coënon, Mauricio Campos-Mora, Carine Jacquard, Fei Gao, Sara Zemiti, Jessy Presumey, Guillaume Cartron, Jérome Moreaux, Martin Villalba
Publicado en: OncoImmunology, Edición 13, 2024, ISSN 2162-402X
Editor: Taylor & Francis Online
DOI: 10.1080/2162402X.2024.2388306

Cancers

Autores: Kyriaki Savva; Marilena M. Bourdakou; Dimitris Stellas; Jerome Zoidakis; George M. Spyrou
Publicado en: Cancers, 2025, ISSN 2072-6694
Editor: MDPI
DOI: 10.3390/CANCERS17183045

Easy Proteomics Sample Preparation: Technical Repeatability and Workflow Optimization Across 8 Biological Matrices in a New Core Facility Setting

Autores: Paraskevi Karousi, Maria Voumvouraki, Panagiota Efstathia Nikolaou, Ioannis Kollias, Foteini Paradeisi, Elena Sampanai, Vasiliki Gkalea, Ioannis Morianos, Jerome Zoidakis, Efstathios Kastritis, Nikolaos Thomaidis, Guillaume Médard, Julie Courraud
Publicado en: PROTEOMICS, Edición 25, 2025, ISSN 1615-9861
Editor: Wiley-VCH
DOI: 10.1002/PMIC.70064

Proteomic Analysis of Bone Marrow CD138+ Cells to Identify Proteins Associated With the Response of Multiple Myeloma Patients to Commonly Used Therapeutic Regimens

Autores: Foteini Paradeisi; Aggeliki Tserga; Vasiliki Lygirou; Manousos Makridakis; Rafael Stroggilos; Grigoris Georgiou; George M. Spyrou; Ioannis V. Kostopoulos; Christine‐Ivy Liacos; Aikaterini Termentzi; Meletios A. Dimopoulos; Ourania Tsitsilonis; Antonia Vlahou; Efstathios Kastritis; Jerome Zoidakis
Publicado en: PROTEOMICS, 2025, ISSN 1615-9861
Editor: John Wiley & Sons
DOI: 10.1002/PMIC.70025

Immunophenotypic portrait of leukemia-associated-phenotypemarkers in B acute lymphoblastic leukemia

Autores: Emilia Boris, Alexandre Theron, Valentin Montagnon,Nicolas Rouquier, Marion Almeras, Jérôme Moreaux, Caroline Bret
Publicado en: CLINICAL CYTOMETRY, ISSN 1552-4957
Editor: Wiley
DOI: 10.1002/CYTO.B.22153

Low circulating tumor cell levels correlate with favorable outcomes and distinct biological features in multiple myeloma

Autores: Ioannis V. Kostopoulos, Ioannis Ntanasis‐Stathopoulos, Pantelis Rousakis, Panagiotis Malandrakis, Chrysanthi Panteli, Evangelos Eleutherakis‐Papaiakovou, Nikolaos Angelis, Vasiliki Spiliopoulou, Rodanthi‐Eleni Syrigou, Panagiotis Bakouros, Georgia Dimitrakopoulou, Despina Fotiou, Magdalini Migkou, Nikolaos Kanellias, Nikolaos Paschalidis, Maria Gavriatopoulou, Efstathios Kastritis, Meletios‐Athanasios Dimopoulos, Ourania E. Tsitsilonis, Evangelos Terpos
Publicado en: American Journal of Hematology, Edición 99, 2025, ISSN 0361-8609
Editor: Wiley
DOI: 10.1002/AJH.27414

International Journal of Molecular Sciences

Autores: Panagiotis Malamos, Christina Papanikolaou, Elisavet Deligianni, Dimitra Mavroeidi, Konstantinos Koutoulogenis, Maria Gavriatopoulou, Evangelos Terpos, Vassilis L. Souliotis
Publicado en: International Journal of Molecular Sciences, Edición 26, 2025, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/IJMS262010171

Cytometry Part B - Clinical Cytometry

Autores: Pauline Marianini, Vanessa Lacheretz‐Szablewski, Marion Almeras, Jérôme Moreaux, Caroline Bret
Publicado en: Cytometry Part B: Clinical Cytometry, Edición 106, 2024, ISSN 1552-4949
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/CYTO.B.22208

Integrative single-cell chromatin and transcriptome analysis of human plasma cell differentiation

Autores: Elina Alaterre, Sara Ovejero, Caroline Bret, Laure Dutrieux, Dassou Sika, Raul Fernandez Perez, Marion Espéli, Thierry Fest, Michel Cogné, José Ignacio Martin-Subero, Pierre Milpied, Giacomo Cavalli, Jérôme Moreaux
Publicado en: Blood, ISSN 1528-0020
Editor: American Society of Hematology
DOI: 10.1182/BLOOD.2023023237

The Interplay between the DNA Damage Response (DDR) Network and the Mitogen-Activated Protein Kinase (MAPK) Signaling Pathway in Multiple Myeloma

Autores: Panagiotis Malamos , Christina Papanikolaou , Maria Gavriatopoulou , Meletios A. Dimopoulos , Evangelos Terpos , Vassilis L. Souliotis
Publicado en: Int. J. Mol. Sci., ISSN 1422-0067
Editor: MDPI
DOI: 10.3390/IJMS25136991

Low circulating tumor cell levels correlate with favorable outcomes and distinct biological features in multiple myeloma

Autores: Ioannis V. Kostopoulos, Ioannis Ntanasis-Stathopoulos, Pantelis Rousakis, Panagiotis Malandrakis, Chrysanthi Panteli, Evangelos Eleutherakis-Papaiakovou, Nikolaos Angelis, Vasiliki Spiliopoulou, Rodanthi-Eleni Syrigou, Panagiotis Bakouros, Georgia Dimitra
Publicado en: The American Journal of Hematology, ISSN 1096-8652
Editor: Wiley Periodicals, LLC.
DOI: 10.1002/AJH.27414

Dynamics of Mutant Hematopoietic Progenitor Cells Are Not Associated with Clinical Outcomes in Multiple Myeloma

Autores: Camila Guerrero, Maria-Jose Larrayoz, Irache Erdozain, Noemi Puig, Maria-Teresa Cedena, Catarina Maia, Amagoia Mañu, Natalia Gordillo, Oihane Churruca, Diego Alignani, Sarai Sarvide, Iria Vazquez, Cristina Perez, Albert Oriol, Laura Rosinol, Rafael Ríos-Tamayo, Marta-Sonia Gonzalez-Perez, Ana-Pilar Gonzalez-Rodriguez, Felipe de Arriba, Jose M. Moraleda, Jesus Martin, Luis Palomera, Valentin Cabañas, Maria-Jose Calasanz, Joaquin Martinez-Lopez, Maria-Victoria Mateos, Joan Bladé, Juan-Jose Lahuerta, Jesus F. San-Miguel, Bruno Paiva
Publicado en: Blood Cancer Discovery, Edición 6, 2025, ISSN 2643-3230
Editor: American Association for Cancer Research (AACR)
DOI: 10.1158/2643-3230.BCD-24-0274

Ranking of cell clusters in a single-cell RNA-sequencing analysis framework using prior knowledge

Autores: Anastasis Oulas; Kyriaki Savva; Nestoras Karathanasis; George M Spyrou
Publicado en: PLoS ONE, 2023, ISSN 1932-6203
Editor: PLOS.ORG
DOI: 10.1101/2023.10.02.560416

Exploring the molecular biomarker utility of circCCT3 in multiple myeloma: A favorable prognostic indicator, particularly for R-ISS II patients

Autores: Maria Papatsirou, Christos K. Kontos,corresponding author, Ioannis Ntanasis‐Stathopoulos, Panagiotis Malandrakis, Diamantis C. Sideris, Despina Fotiou, ......, Efstathios Kastritis, Meletios A. Dimopoulos, Andreas Scorilas and Evangelos Terpos
Publicado en: Hemasphere, ISSN 0045-6535
Editor: PubMed
DOI: 10.1002/HEM3.34

International Journal of Molecular Sciences

Autores: Elisavet Deligianni; Christina Papanikolaou; Evangelos Terpos; Vassilis L. Souliotis
Publicado en: International Journal of Molecular Sciences, 2025, ISSN 1422-0067
Editor: MDPI
DOI: 10.3390/IJMS26125849

Direct visualization of chimeric antigen receptors on primary human T cells using dSTORM super-resolution microscopy

Autores: Leon Gehrke; Nicole Seifert; Peter Spieler; Christina Verbruggen; Rick Seifert; Fabio Toppeta; Maximilian Krick; Sören Doose; Hermann Einsele; Hermann Einsele; Hermann Einsele; Michael Hudecek; Michael Hudecek; Michael Hudecek; Markus Sauer; Thomas Nerreter
Publicado en: Frontiers in Immunology, 2025, ISSN 1664-3224
Editor: Frontiers Media
DOI: 10.3389/FIMMU.2025.1632823

Small RNA-seq and clinical evaluation of tRNA-derived fragments in multiple myeloma: Loss of mitochondrial i-tRFHisGTG results in patients' poor treatment outcome

Autores: Konstantinos Soureas, Maria-Alexandra Papadimitriou, Panagiotis Malandrakis, Aristea-Maria Papanota,Efstathios Kastritis, Meletios-Athanasios Dimopoulos, Andreas Scorilas, Evangelos Terpos, Margaritis Avgeris
Publicado en: BJHaem., ISSN 1365-2141
Editor: Wiley
DOI: 10.1111/BJH.19332

Theranostics

Autores: Ovejero, Sara; Alibert, Laura; Devin, Julie; Cañeque, Tatiana; Jacquier, Valentin; Romero, Andrea; Amar, Salome; Abouladze, Matthieu; de Paco, Elvira Garcia; Gadacha, Ouissem Karmous; Requirand, Guilhem; Robert, Nicolas; Zellagui, Miss Leriem; de Boussac, Hugues; Cartron, Guillaume; Chiche, Johanna; Ricci, Jean-Ehrland; Herbaux, Charles; Rodriguez, Raphaël; Moreaux, Jerome; Bret, Caroline
Publicado en: Theranostics, 2025, ISSN 1838-7640
Editor: Ivyspring International Publisher
DOI: 10.7150/THNO.101821

Predictors of unsustained measurable residual disease negativity in transplant-eligible patients with multiple myeloma

Autores: Camila Guerrero, Noemi Puig, María-Teresa Cedena, María-José Calasanz, Norma C. Gutierrez, Manuela Fernandez, Albert Oriol,......,Laura Rosinol, Joan Bladé, Juan-Jose Lahuerta, Jesus F. San-Miguel, and Bruno Paiva
Publicado en: Blood, ISSN 1528-0020
Editor: American Society of Hematology
DOI: 10.1182/BLOOD.2023022083

Predictors of unsustained measurable residual disease negativity in patients with multiple myeloma

Autores: Mattia D’Agostino,Giuseppe Bertuglia, Delia Rota-Scalabrini, Angelo Belotti, Sonia More, Paolo Corradini, Stefania Oliva,.....,Maria Teresa Petrucci, Benedetto Bruno, Pellegrino Musto, and Francesca Gay
Publicado en: Blood, ISSN 1528-0020
Editor: American Society of Hematology
DOI: 10.1182/BLOOD.2023022080

Combined inhibition of Wee1 and Chk1 as a therapeutic strategy in multiple myeloma

Autores: Angelique Bruyer, Laure Dutrieux, Hugues de Boussac, Thibaut Martin, Djamila Chemlal, Nicolas Robert, Guilhem Requirand, Guillaume Cartron, Laure Vincent, Charles Herbaux, Malik Lutzmann, Caroline Bret, Philippe Pasero, Jerome Moreaux and Sara Ovejero
Publicado en: Frontiers in Oncology, ISSN 2234-943X
Editor: Frontiers Media S. A.
DOI: 10.3389/FONC.2023.1271847

Synthetic Lethal Combinations of DNA Repair Inhibitors and Genotoxic Agents to Target High‐Risk Diffuse Large B Cell Lymphoma

Autores: Sara Ovejero; Julie Devin; Laura Alibert; Camille Soun; Yea‐Lih Lin; Laure Dutrieux; Matthieu Abouladze; Elvira Garcia de Paco; Ouissem Karmous Gadacha; Angelos Constantinou; Guillaume Cartron; Charles Herbaux; Olivier Elemento; Philippe Pasero; Sandrine Roulland; Jérôme Moreaux; Caroline Bret
Publicado en: Hematological Oncology, 2025, ISSN 1099-1069
Editor: John Wiley & Sons Ltd
DOI: 10.1002/HON.70131

CD200 immune checkpoint expression is associated with inferior outcome in multiple myeloma patients treated with anti-CD38 monoclonal antibodies

Autores: Djamila Chemlal; Camille Pochard; Valentin Jacquier; Angélique Bruyer; Ludovic Gabellier; Léa Fornero; Clément Vempère; Amélie Machura; Guilhem Requirand; Nicolas Robert; Caroline Bret; Guillaume Cartron; Laure Vincent; Hugues de Boussac; Jérôme Moreaux; Charles Herbaux
Publicado en: OncoImmunology, 2025, ISSN 2162-402X
Editor: Taylor & Francis Group
DOI: 10.1080/2162402X.2025.2532226