Engineering synthetic mechanotransduction through nucleocytoplasmic transport

Project Information

MechanoSynth

Grant agreement ID: 101097753

DOI

10.3030/101097753

EC signature date 21 June 2023

Start date 1 December 2023

End date 30 November 2028

Funded under

• European Research Council (ERC)

Total cost

€ 2 499 875,00

EU contribution

€ 2 499 875,00

Coordinated by

FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA
Spain

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (17)

Micro Immune Response On-chip (MIRO) models the tumour-stroma interface for immunotherapy testing

Author(s): Alice Perucca, Andrea Gómez Llonín, Oriol Mañé Benach, Clement Hallopeau, Elisa I. Rivas, Jenniffer Linares, Marta Garrido, Anna Sallent-Aragay, Tom Golde, Julien Colombelli, Eleni Dalaka, Judith Linacero, Marina Cazorla, Teresa Galan, Jordi Pastor Viel, Xavier Badenas, Alba Recort-Bascuas, Laura Comerma, Patricia Fernandez-Nogueira, Ana Rovira, Pere Roca-Cusachs, Joan Albanell, Xavier Trepat, Alexandre Calon, Anna Labernadie
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-56275-1

Optogenetic generation of leader cells reveals a force–velocity relation for collective cell migration

Author(s): Leone Rossetti; Steffen Grosser; Juan Francisco Abenza; Léo Valon; Pere Roca-Cusachs; Ricard Alert; Xavier Trepat
Published in: Nature Physics, 2024, ISSN 1745-2481
Publisher: Nature
DOI: 10.1101/2024.01.23.576733

Nature Communications

Author(s): Alice Perucca; Andrea Gómez Llonín; Oriol Mañé Benach; Clement Hallopeau; Elisa I. Rivas; Jenniffer Linares; Marta Garrido; Anna Sallent-Aragay; Tom Golde; Julien Colombelli; Eleni Dalaka; Judith Linacero; Marina Cazorla; Teresa Galan; Jordi Pastor Viel; Xavier Badenas; Alba Recort-Bascuas; Laura Comerma; Patricia Fernandez-Nogueira; Ana Rovira; Pere Roca-Cusachs; Joan Albanell; Xavier Trepat; Alexandre Calon; Anna Labernadie
Published in: Nature Communications, 2025, ISSN 2041-1723
Publisher: Nature
DOI: 10.1038/S41467-025-56275-1

Nucleocytoplasmic transport senses mechanical forces independently of cell density in cell monolayers

Author(s): Ignasi Granero-Moya; Valeria Venturini; Guillaume Belthier; Bart Groenen; Marc Molina-Jordán; Miguel González-Martín; Xavier Trepat; Jacco van Rheenen; Ion Andreu; Pere Roca-Cusachs
Published in: Journal of Cell Science, 2024, ISSN 1477-9137
Publisher: The company of biologists
DOI: 10.1242/JCS.262363

3D Micropatterned Traction Force Microscopy: A Technique to Control 3D Cell Shape While Measuring Cell‐Substrate Force Transmission

Author(s): Faure, Laura M.; Gómez González, Manuel; Baguer, Ona; Comelles, Jordi; Martínez Fraiz, Elena; Arroyo Balaguer, Marino; Trepat Guixer, Xavier; Roca Cusachs, Pere
Published in: Advanced Science, 2024, ISSN 2198-3844
Publisher: Wiley
DOI: 10.1002/ADVS.202406932

Nature Communications

Author(s): Eva Barcelona-Estaje; Mariana A. G. Oliva; Finlay Cunniffe; Aleixandre Rodrigo-Navarro; Paul Genever; Matthew J. Dalby; Pere Roca-Cusachs; Marco Cantini; Manuel Salmeron-Sanchez
Published in: Nature Communications, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/S41467-024-53107-6

Regulation of cell dynamics by rapid integrin transport through the biosynthetic pathway

Author(s): Martina Lerche, Mathilde Mathieu, Hellyeh Hamidi, Megan Chastney, Guillaume Jacquemet, Bart Marlon Herwig Bruininks, Shreyas Kaptan, Lene Malerød, Nina Marie Pedersen, Andreas Brech, Nobuyuki Matoba, Yuichiro Sato, Ilpo Vattulainen, Pere Roca-Cusachs, Franck Perez, Gaelle Boncompain, Stéphanie Miserey, Johanna Ivaska
Published in: Journal of Cell Biology, Issue 225, 2026, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/JCB.202508155

N-cadherin crosstalk with integrin weakens the molecular clutch in response to surface viscosity

Author(s): Eva Barcelona-Estaje, Mariana A. G. Oliva, Finlay Cunniffe, Aleixandre Rodrigo-Navarro, Paul Genever, Matthew J. Dalby, Pere Roca-Cusachs, Marco Cantini, Manuel Salmeron-Sanchez
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41467-024-53107-6

Equibiaxial Stretching Device for High Magnification Live-Cell Confocal Fluorescence Microscopy

Author(s): Anabel-Lise Le Roux, Valeria Venturini, Manuel Gómez-González, Amy E. M. Beedle, Xarxa Quiroga, Xavier Menino, Xavier Trepat, Pere Roca-Cusachs
Published in: Journal of Visualized Experiments, 2025, ISSN 1940-087X
Publisher: MyJove Corporation
DOI: 10.3791/67520

Nature Communications

Author(s): Sefora Conti; Valeria Venturini; Adrià Cañellas-Socias; Carme Cortina; Juan F. Abenza; Camille Stephan-Otto Attolini; Emily Middendorp Guerra; Catherine K. Xu; Jia Hui Li; Leone Rossetti; Giorgio Stassi; Pere Roca-Cusachs; Alba Diz-Muñoz; Verena Ruprecht; Jochen Guck; Eduard Batlle; Anna Labernadie; Xavier Trepat
Published in: Nature Communications, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1101/2023.12.04.569244

Cell compression – relevance, mechanotransduction mechanisms and tools

Author(s): Laura M. Faure, Valeria Venturini, Pere Roca-Cusachs
Published in: Journal of Cell Science, Issue 138, 2025, ISSN 0021-9533
Publisher: The Company of Biologists
DOI: 10.1242/JCS.263704

Fibrillar adhesion dynamics govern the timescales of nuclear mechano-response via the vimentin cytoskeleton

Author(s): Amy E. M. Beedle, Vivek Sharma, Jorge Oliver-De La Cruz, Anuja Jaganathan, Aina Albajar-Sigalés, F. Max Yavitt, Kaustav Bera, Ion Andreu, Ignasi Granero-Moya, Dobryna Zalvidea, Zanetta Kechagia, Gerhard Wiche, Xavier Trepat, Johanna Ivaska, Kristi S. Anseth, Vivek B. Shenoy, Pere Roca-Cusachs
Published in: Nature Materials, Issue 25, 2026, ISSN 1476-1122
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41563-026-02590-X

Guidance of cellular nematic elastomers into shape-programmable living surfaces

Author(s): Pau Guillamat, Waleed Mirza, Pradeep K. Bal, Manuel Gómez-González, Pere Roca-Cusachs, Marino Arroyo, Xavier Trepat
Published in: Science, Issue 392, 2026, ISSN 0036-8075
Publisher: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/SCIENCE.ADZ9174

Piezo1 is a mechanosensor of soft matrix viscoelasticity

Author(s): Manuel Salmeron-Sanchez; Mariana Oliva; Giuseppe Ciccone; Gotthold Fläschner; Jianjun Luo; Jonah Voigt; Patrizia Romani; Paul Genever; Oana Dobre; Sirio Dupont; Massimo Vassalli; Pere Roca-Cusachs
Published in: Crossref, 2025, ISSN 2693-5015
Publisher: Research square
DOI: 10.21203/RS.3.RS-6074849/V1

Membrane to cortex attachment determines different mechanical phenotypes in LGR5+ and LGR5- colorectal cancer cells

Author(s): Sefora Conti, Valeria Venturini, Adrià Cañellas-Socias, Carme Cortina, Juan F. Abenza, Camille Stephan-Otto Attolini, Emily Middendorp Guerra, Catherine K. Xu, Jia Hui Li, Leone Rossetti, Giorgio Stassi, Pere Roca-Cusachs, Alba Diz-Muñoz, Verena Ruprecht, Jochen Guck, Eduard Batlle, Anna Labernadie, Xavier Trepat
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41467-024-47227-2

Single-cell migration along and against confined haptotactic gradients

Author(s): Isabela Corina Fortunato; David B. Brückner; Steffen Grosser; Rohit Nautiyal; Leone Rossetti; Miquel Bosch-Padrós; Jonel Trebicka; Pere Roca-Cusachs; Raimon Sunyer; Edouard Hannezo; Xavier Trepat
Published in: Nature Physics, 2025, ISSN 1745-2481
Publisher: Nature
DOI: 10.1038/S41567-025-03015-3

Mechanotransduction by nuclear envelope tension

Author(s): Sriivatsan G. Rajan, Pere Roca-Cusachs, Philipp Niethammer
Published in: Nucleus, Issue 17, 2025, ISSN 1949-1034
Publisher: Informa UK Limited
DOI: 10.1080/19491034.2025.2600901