CHARTING THE TOKEN OF TIME: YAP/TAZ TRANSCRIPTIONAL REGULATORS AT THE ROOTS OF AGING

Project Information

CHARTAGING

Grant agreement ID: 101098074

DOI

10.3030/101098074

EC signature date 19 June 2023

Start date 1 January 2024

End date 31 December 2028

Funded under

• European Research Council (ERC)

Total cost

€ 2 811 871,00

EU contribution

€ 2 811 871,00

Coordinated by

UNIVERSITA DEGLI STUDI DI PADOVA
Italy

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Publications

Peer reviewed articles (5)

Timing Mechanotransduction: Mechanically Dynamic Biomaterials Reveal the Temporal Hierarchy of YAP/TAZ Control Nodes

Author(s): Alessandro Gandin, Giada Vanni, Veronica Torresan, Margherita Pelosin, Rebecca Busetto, Anna Citron, Ambela Suli, Paolo Contessotto, Carlo Albanese, Francesca Zanconato, Tito Panciera, Stefano Piccolo, Giovanna Brusatin
Published in: Advanced Science, 2026, ISSN 2198-3844
Publisher: Wiley
DOI: 10.1002/ADVS.202515210

Combining spatial transcriptomics and ECM imaging in 3D for mapping cellular interactions in the tumor microenvironment

Author(s): Tancredi Massimo Pentimalli, Simon Schallenberg, Daniel León-Periñán, Ivano Legnini, Ilan Theurillat, Gwendolin Thomas, Anastasiya Boltengagen, Sonja Fritzsche, Jose Nimo, Lukas Ruff, Gabriel Dernbach, Philipp Jurmeister, Sarah Murphy, Mark T. Gregory, Yan Liang, Michelangelo Cordenonsi, Stefano Piccolo, Fabian Coscia, Andrew Woehler, Nikos Karaiskos, Frederick Klauschen, Nikolaus Rajewsky
Published in: Cell Systems, Issue 16, 2025, ISSN 2405-4712
Publisher: Elsevier BV
DOI: 10.1016/J.CELS.2025.101261

Mechanical stress during confined migration causes aberrant mitoses and c-MYC amplification

Author(s): Giulia Bastianello, Gururaj Rao Kidiyoor, Conor Lowndes, Qingsen Li, Raoul Bonnal, Jeffrey Godwin, Fabio Iannelli, Lorenzo Drufuca, Ramona Bason, Fabrizio Orsenigo, Dario Parazzoli, Mattia Pavani, Valeria Cancila, Stefano Piccolo, Giorgio Scita, Andrea Ciliberto, Claudio Tripodo, Massimiliano Pagani, Marco Foiani
Published in: Proceedings of the National Academy of Sciences, Issue 121, 2024, ISSN 0027-8424
Publisher: Proceedings of the National Academy of Sciences
DOI: 10.1073/PNAS.2404551121

Microtubule architecture connects AMOT stability to YAP/TAZ mechanotransduction and Hippo signalling

Author(s): Giada Vanni, Anna Citron, Ambela Suli, Paolo Contessotto, Robin Caire, Alessandro Gandin, Giovanna Mantovan, Francesca Zanconato, Giovanna Brusatin, Michele Di Palma, Elisa Peirano, Lisa Sofia Pozzer, Carlo Albanese, Roberto A. Steiner, Michelangelo Cordenonsi, Tito Panciera, Stefano Piccolo
Published in: Nature Cell Biology, Issue 27, 2025, ISSN 1465-7392
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41556-025-01773-Z

Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling

Author(s): Keith Graham, Philip Lienau, Benjamin Bader, Stefan Prechtl, Jan Naujoks, Ralf Lesche, Joerg Weiske, Julia Kuehnlenz, Krzysztof Brzezinka, Lisette Potze, Francesca Zanconato, Barbara Nicke, Anna Montebaur, Wilhelm Bone, Sven Golfier, Stefan Kaulfuss, Charlotte Kopitz, Sabine Pilari, Holger Steuber, Sikander Hayat, Atanas Kamburov, Andreas Steffen, Andreas Schlicker, Philipp Buchgraber, Nico Braeuer, Nuria Aiguabella Font, Tobias Heinrich, Lara Kuhnke, Katrin Nowak-Reppel, Carlo Stresemann, Patrick Steigemann, Annette O. Walter, Simona Blotta, Matthias Ocker, Ashley Lakner, Franz von Nussbaum, Dominik Mumberg, Knut Eis, Stefano Piccolo, Martin Lange
Published in: Cell Chemical Biology, Issue 31, 2025, ISSN 2451-9456
Publisher: Elsevier BV
DOI: 10.1016/J.CHEMBIOL.2024.02.013