Ubiquitin-Proteasome System crosstalk with Metabolism

Project Information

UPSmeetMet

Grant agreement ID: 101098161

DOI

10.3030/101098161

EC signature date 24 April 2023

Start date 1 October 2023

End date 30 September 2028

Funded under

• European Research Council (ERC)

Total cost

€ 2 089 688,00

EU contribution

€ 2 089 688,00

Coordinated by

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Data Management Plan (1)

Data Management Plan

Publications

Peer reviewed articles (9)

Cysteine availability tunes ubiquitin signaling via inverse stability of LRRC58 E3 ligase and its substrate CDO1

Author(s): Gisele A. Andree, Luca J. Stier, Kerstin Schmiederer, Alina S. Thielen, Luis Schmid, Samuel A. Maiwald, Karthik V. Gottemukkala, Jiale Du, Susanne von Gronau, Claudia Strasser, Judith Müller, Lukas T. Henneberg, Camille Guyot, Gary Kleiger, Matthias Mann, Peter J. Murray, Brenda A. Schulman
Published in: Nature Communications, Issue 17, 2026, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41467-026-72524-3

Multisite phosphorylation dictates selective E2-E3 pairing as revealed by Ubc8/UBE2H-GID/CTLH assemblies

Author(s): Jakub Chrustowicz, Dawafuti Sherpa, Jerry Li, Christine R. Langlois, Eleftheria C. Papadopoulou, D. Tung Vu, Laura A. Hehl, Özge Karayel, Viola Beier, Susanne von Gronau, Judith Müller, J. Rajan Prabu, Matthias Mann, Gary Kleiger, Arno F. Alpi, Brenda A. Schulman
Published in: Molecular Cell, Issue 84, 2024, ISSN 1097-2765
Publisher: Elsevier BV
DOI: 10.1016/J.MOLCEL.2023.11.027

Non-canonical substrate recognition by the human WDR26-CTLH E3 ligase regulates prodrug metabolism

Author(s): Karthik V. Gottemukkala, Jakub Chrustowicz, Dawafuti Sherpa, Sara Sepic, Duc Tung Vu, Özge Karayel, Eleftheria C. Papadopoulou, Annette Gross, Kenji Schorpp, Susanne von Gronau, Kamyar Hadian, Peter J. Murray, Matthias Mann, Brenda A. Schulman, Arno F. Alpi
Published in: Molecular Cell, Issue 84, 2024, ISSN 1097-2765
Publisher: Elsevier BV
DOI: 10.1016/J.MOLCEL.2024.04.014

The E3 ubiquitin ligase mechanism specifying targeted microRNA degradation

Author(s): Jakob Farnung, Elena Slobodyanyuk, Peter Y. Wang, Lianne W. Blodgett, Daniel H. Lin, Susanne von Gronau, Brenda A. Schulman, David P. Bartel
Published in: Nature, Issue 652, 2026, ISSN 0028-0836
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41586-026-10232-0

Skraban‐Deardorff intellectual disability syndrome‐associated mutations in <scp>WDR</scp>26 impair <scp>CTLH E</scp>3 complex assembly

Author(s): Annette Gross, Judith Müller, Jakub Chrustowicz, Alexander Strasser, Karthik V. Gottemukkala, Dawafuti Sherpa, Brenda A. Schulman, Peter J. Murray, Arno F. Alpi
Published in: FEBS Letters, Issue 598, 2024, ISSN 0014-5793
Publisher: Wiley
DOI: 10.1002/1873-3468.14866

The many faces of the GID/CTLH E3 ligase complex

Author(s): Arno F. Alpi, Jakub Chrustowicz, Dawafuti Sherpa, Brenda A. Schulman
Published in: Biochemical Society Transactions, Issue 53, 2025, ISSN 0300-5127
Publisher: Portland Press Ltd.
DOI: 10.1042/BST20253074

Doa10/MARCH6 architecture interconnects E3 ligase activity with lipid-binding transmembrane channel to regulate SQLE

Author(s): J. Josephine Botsch, Roswitha Junker, Michèle Sorgenfrei, Patricia P. Ogger, Luca Stier, Susanne von Gronau, Peter J. Murray, Markus A. Seeger, Brenda A. Schulman, Bastian Bräuning
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41467-023-44670-5

Charged molecular glue discovery enabled by targeted degron display

Author(s): Zhe Zhuang, Woong Sub Byun, Jakub Chrustowicz, Zuzanna Kozicka, Veronica L. Li, Dinah M. Abeja, Katherine A. Donovan, Sara Sepic, Inchul You, Mikołaj Słabicki, Eric S. Fischer, Stephen M. Hinshaw, Benjamin L. Ebert, Brenda A. Schulman, Nathanael S. Gray
Published in: Nature Chemical Biology, 2026, ISSN 1552-4450
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41589-026-02182-5

Metabolically regulated proteasome supramolecular organization in situ

Author(s): Xiaomeng Tang, Lu Qu, Florian Wilfling, Florian Beck, Oliver P. Ernst, Brenda A. Schulman, Wolfgang Baumeister, Cordula Enenkel
Published in: Cell, Issue 189, 2026, ISSN 0092-8674
Publisher: Elsevier BV
DOI: 10.1016/J.CELL.2025.12.035