Exploring inflammasome activation and targeted inhibition

Project Information

NalpACT

Grant agreement ID: 101098206

DOI

10.3030/101098206

EC signature date 27 November 2023

Start date 1 January 2024

End date 31 December 2028

Funded under

• European Research Council (ERC)

Total cost

€ 2 155 047,00

EU contribution

€ 2 155 047,00

Coordinated by

UNIVERSITATSKLINIKUM BONN
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Data Management Plan (1)

Data Management Plan

Drafting of Data Management Plan

Publications

Peer reviewed articles (6)

Mechanisms of NLRP3 activation and inhibition elucidated by functional analysis of disease-associated variants

Author(s): Shouya Feng, Matthew C. Wierzbowski, Katja Hrovat-Schaale, Andreas Dumortier, Yaoyuan Zhang, Maria Zyulina, Paul J. Baker, Thomas Reygaerts, Annemarie Steiner, Dominic De Nardo, Dhanya Lakshmi Narayanan, Florian Milhavet, Alberto Pinzon-Charry, Juan Ignacio Arostegui, Raju P. Khubchandani, Matthias Geyer, Guilaine Boursier, Seth L. Masters
Published in: Nature Immunology, Issue 26, 2025, ISSN 1529-2908
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41590-025-02088-9

Discovery of potent and selective inhibitors of human NLRP3 with a novel mechanism of action

Author(s): Kevin Wilhelmsen, Aditi Deshpande, Sarah Tronnes, Maitriyee Mahanta, Matthew Banicki, Mary Cochran, Samantha Cowdin, Kristen Fortney, George Hartman, Robert E. Hughes, Rusty Montgomery, Claudia P. Portillo, Paul Rubin, Taiz Salazar, Yan Wang, Shijun Yan, Barry A. Morgan, Assem Duisembekova, Romane Riou, Michael Marleaux, Inga V. Hochheiser, Hannes Buthmann, Dominic Ferber, Jane Torp, Wei Wang, Melanie Cranston, Chloe M. McKee, Thea J. Mawhinney, Emma C. McKay, Fehime K. Eroglu, Jasmin Kümmerle-Deschner, Alexander N.R. Weber, Bénédicte F. Py, Matthias Geyer, Rebecca C. Coll
Published in: Journal of Experimental Medicine, Issue 222, 2025, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/JEM.20242403

Degrading the key component of the inflammasome: development of an NLRP3 PROTAC

Author(s): Tim Keuler, Dominic Ferber, Jonas Engelhardt, Christian Steinebach, Nico Kirsch, Michael Marleaux, Günther Weindl, Matthias Geyer, Michael Gütschow
Published in: Chemical Communications, Issue 61, 2025, ISSN 1359-7345
Publisher: Royal Society of Chemistry (RSC)
DOI: 10.1039/D4CC06321J

The inflammasome sensor NLRP3 interacts with REV7 to maintain genome integrity through homologous recombination

Author(s): Delphine Burlet, Md Muntaz Khan, Sabine Hacot, Hannes Buthmann, Léa Bardoulet, Anne-Laure Huber, Julie Gorry, Bastian Föhr, Bernard S Lopez, Yohann Couté, Alex C Faesen, Matthias Geyer, Agnès Tissier, Virginie Petrilli
Published in: Nucleic Acids Research, Issue 53, 2025, ISSN 0305-1048
Publisher: Oxford University Press (OUP)
DOI: 10.1093/NAR/GKAF554

Clustering of NLRP3 induced by membrane or protein scaffolds promotes inflammasome assembly

Author(s): Elvira Boršić, Taja Železnik Ramuta, Sara Orehek, Mateja Erdani Kreft, Matthias Geyer, Roman Jerala, Iva Hafner-Bratkovič
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-60277-4

Insights into reproduction-regulating NOD-like receptors

Author(s): Inga V. Hochheiser, Matthias Geyer
Published in: Nature Structural & Molecular Biology, Issue 31, 2024, ISSN 1545-9993
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41594-024-01383-7