Periodic Reporting for period 1 - Prometeus (Preterm Brain-Oxygenation and Metabolic EU-Sensing: Feed the Brain)
Período documentado: 2023-02-01 hasta 2024-01-31
The development of the miniaturized on-body patch sensor for the minimally invasive continuous monitoring of the three key brain metabolites: glucose, lactate and beta-hydroxybutyrate (BHB) (CMM) is under development as well. Currently, an adhesive able to provide up to 14 days wearing time with minimal skin irritability has been identified and the biocompatibility of the patch and microprobe chip components verified in an animal model.
The first steps towards developing the metabolic neonatal model, and consequently, the algorithm to provide personalized nutrition to target brain health, have been taken, by planning and optimizing the animal experiments, which will provide the first data for the model.
The development of the Prometeus Cloud-based environment for handling, in the neonatal intensive care unit, the on-body monitoring system developed during Prometeus is under development as well. So far, a first prototype is available, which consists of the Prometeus Edge Unit, a field device that interoperates with neo-opticap and CMM and handle the individual nutritional information provided by the above-mentioned algorithm, and the Prometeus Cloud Service, a cloud platform that manages the Prometeus Edge Unit and collects and back-up the data.
Finally, the assessment tool that will be used to evaluate the impact of on-body monitoring devices on parents and health care personnel and their experience with preterm neonates is almost completed. The script that will be used in the interview of parents and health care personnel for the creation of the first Visual and Oral Archive of prematurity is under development.