Project description DEENESFRITPL Neurostimulation and brain imaging in a single device Electroencephalography (EEG) is a non-invasive method that measures electrical activity in the brain. It is commonly used in clinical and research settings to study various neurological conditions, including epilepsy, as well as evaluate brain function during cognitive tasks. However, EEG is limited to neural tissue close to the skull. Funded by the European Innovation Council, the AEGEUS project aims to develop a new device that can deliver images from deeper brain regions. The wearable device will combine ultrasound imaging, brain stimulation, and electrophysiological measurements to diagnose and treat neurological conditions. In addition, the consortium aims to introduce a neuromodulation component to stimulate specific areas of the brain on the basis of abnormal activity. Show the project objective Hide the project objective Objective The overall goal of this project is to develop a radically new diagnostic and therapeutic device for neurological applications which combines a highly innovative ultrasound component for brain imaging and focused stimulation of brain regions with advanced electrophysiological measurements of neural activity.First goal of the project is the development of a novel ultrasound (US)-based functional imaging method that, in conjunction with electroencephalography (EEG), allows for high spatiotemporal resolution examination of brain activity. While EEG itself yields best data from neural tissue close to the skull, the US component is designed to deliver images from deeper brain regions.The second pillar of the device’s function is focused US brain stimulation. Based on the possibility to localize abnormal activity, the neuromodulation component of the novel device can be guided to focal stimulation of selected brain regions, which can be further developed into a closed-loop design. The full envisioned system is a versatile tool that combines EEG-sensors and US transceivers in a wearable headset. The project foresees the development of hard- and software as well as algorithms to integrate the information from both modalities into functional neuroimaging with unpreceded spatiotemporal resolution.Beyond the technical realization, this project includes a proof of concept study to evaluate and demonstrate practical applicability in healthy participants and in patients with epilepsy, during clinical routine examination, cognitive, and sensory stimulation, including test-retest validation. The new device will reduce the time to examine and treat neurological patients and the cost thereof. The ability to perform better diagnosis via accurate imaging, targeted neurostimulation, and neuromodulation with a cost-effective, non-invasive device will have transformative effects on treatment options for neurological diseases and stimulate new lines of research in cognitive neuroscience Fields of science medical and health sciencesbasic medicineneurologyepilepsynatural sciencescomputer and information sciencessoftwarenatural sciencesbiological sciencesneurobiologycognitive neurosciencenatural sciencesphysical sciencesacousticsultrasound Keywords ultrasound eeg imaging stimulation proof of concept Programme(s) HORIZON.3.1 - The European Innovation Council (EIC) Main Programme Topic(s) HORIZON-EIC-2022-PATHFINDEROPEN-01-01 - EIC Pathfinder Open 2022 Call for proposal HORIZON-EIC-2022-PATHFINDEROPEN-01 See other projects for this call Funding Scheme EIC - EIC Coordinator FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV Net EU contribution € 1 390 000,00 Address Hansastrasse 27c 80686 Munchen Germany See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Participants (5) Sort alphabetically Sort by Net EU contribution Expand all Collapse all UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA Italy Net EU contribution € 306 263,75 Address Piazzale aldo moro 5 00185 Roma See on map Region Centro (IT) Lazio Roma Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 HASKOLINN A AKUREYRI Iceland Net EU contribution € 320 625,00 Address Solborg v nordurslod 600 Akureyri See on map Region Ísland Ísland Landsbyggð Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 G.TEC MEDICAL ENGINEERING GMBH Austria Net EU contribution € 438 437,50 Address Sierningstrasse 14 4521 Schiedlberg See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Westösterreich Oberösterreich Steyr-Kirchdorf Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 GEMEINNUTZIGE SALZBURGER LANDESKLINIKEN BETRIEBSGESELLSCHAFT Austria Net EU contribution € 262 412,50 Address Mullner hauptstrasse 48 5020 Salzburg See on map Region Westösterreich Salzburg Salzburg und Umgebung Activity type Other Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 PERCUROS BV Netherlands Net EU contribution € 281 250,00 Address Eerbeeklaan 42 2573 HT 's-gravenhage (den haag) See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region West-Nederland Zuid-Holland Agglomeratie ’s-Gravenhage Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Partners (1) Sort alphabetically Sort by Net EU contribution Expand all Collapse all UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA Italy Net EU contribution € 0,00 Address Via cracovia 50 00133 Roma See on map Region Centro (IT) Lazio Roma Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00
