Project description
More accurate and efficient deep body functional imaging
The visualisation of internal organs and structures, as well as the monitoring of their functions, is important for the diagnosis and treatment of various medical conditions like cancer and cardiovascular disease. Currently, ultrasound, X-rays, positron emission tomography, and MRI are used for monitoring organs and deep body imaging, but they have their limitations. The EU-funded fastMOT project aims to revolutionise the way deep body functional imaging is done. It proposes a light sensing solution, an ultra-fast and highly efficient single-photon sensor based on superconducting nanowire detectors. By combining optical gating and charge coupling, it will scale up to 10 000 pixels and millimetre diameter to enable multifunctional deep body imaging with diffuse optics.
Objective
Traditionally, monitoring of organs and deep body functional imaging is done by ultrasound, X-Rays (incl CT), PET or MRI. These techniques only allow for very limited measurements of functionality, usually combined with exogenous and radioactive agents. In this project we propose an innovative light sensing solution, a fast gated, ultra-high quantum efficiency single-photon sensor, to enable multi-functional deep body imaging with diffuse optics. The new type of sensor is based on superconducting nanowire single-photon detectors, that have shown to be ultra-fast and highly efficient. However, until now the active area and number of pixels has been limited to micrometers diameter and tens of pixels. We propose the combination of two new readout techniques, optical gating and charge coupling, to overcome this limit and scale to 10,000 pixels and millimeter diameter. In addition we will develop new strategies for performing TD-NIRS and TD-SCOS to use this new light sensor optimally with Monte-Carlo simulations. We will implement the new light sensor in an optical tomograph and achieve a 100x improvement of SNR compared to using existing light sensors. With our proposed Multifunctional Optical Tomograph we will be able to image deep organ and optical structures and monitor functions including oxygenation, haemodynamics, perfusion and metabolism
Fields of science
Keywords
Programme(s)
- HORIZON.3.1 - The European Innovation Council (EIC) Main Programme
Funding Scheme
HORIZON-EIC - HORIZON EIC GrantsCoordinator
2628 ER Delft
Netherlands
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.