Transcription Factor Gene Therapy for Bradyarrhythmias

Project Information

TRACTION

Grant agreement ID: 101099608

DOI

10.3030/101099608

Project closed

EC signature date 21 November 2022

Start date 1 January 2023

End date 31 December 2025

Funded under

• The European Innovation Council (EIC)

Total cost

€ 2 499 968,75

EU contribution

€ 2 499 968,00

Coordinated by

PACINGCURE B.V.
Netherlands

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (5)

Living myocardial slices as a model for testing cardiac pro-reparative gene therapies

Author(s): Rocco Caliandro, Azra Husetić, Merel L. Ligtermoet, Arie R. Boender, Lorena Zentilin, Gerard J.J. Boink, Mauro Giacca, Monika M. Gladka
Published in: Molecular Therapy, Issue 33, 2025, ISSN 1525-0016
Publisher: Elsevier BV
DOI: 10.1016/J.YMTHE.2025.03.033

Directed Evolution of AAV9 for Efficient Gene Expression in Cardiomyocytes <i>In Vitro</i> and <i>In Vivo</i>

Author(s): Leonard Hüttermann, Lena C. Schröder, Prithviraj M.V. Shetty, Timo Jonker, Susanne S. Hille, Anca Kliesow Remes, Andrea Matzen, Arie R. Boender, Dirk Grimm, Derk Frank, Gerard J.J. Boink, Thomas Eschenhagen, Dennis Schade, Oliver J. Müller
Published in: Human Gene Therapy, Issue 36, 2026, ISSN 1043-0342
Publisher: SAGE Publications
DOI: 10.1089/HUM.2024.126

Cross-species comparison reveals that Hmga1 reduces H3K27me3 levels to promote cardiomyocyte proliferation and cardiac regeneration

Author(s): Mara Bouwman, Dennis E. M. de Bakker, Hessel Honkoop, Alexandra E. Giovou, Danielle Versteeg, Arie R. Boender, Phong D. Nguyen, Merel Slotboom, Daniel Colquhoun, Marta Vigil-Garcia, Lieneke Kooijman, Rob Janssen, Ingeborg B. Hooijkaas, Marie Günthel, Kimberly J. Visser, Mischa Klerk, Lorena Zentilin, Mauro Giacca, Jan Kaslin, Gerard J. J. Boink, Eva van Rooij, Vincent M. Christoffels, Jeroen Bakkers
Published in: Nature Cardiovascular Research, Issue 4, 2025, ISSN 2731-0590
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S44161-024-00588-9

<i>SCN10A-short</i> gene therapy to restore conduction and protect against malignant cardiac arrhythmias

Author(s): Jianan Wang; Arie O Verkerk; Ronald Wilders; Yingnan Zhang; Kelly Zhang; Adityo Prakosa; Mathilde R Rivaud; E Madelief J Marsman; Arie R Boender; Mischa Klerk; Lianne Fokkert; Berend de Jonge; Klaus Neef; Osne F Kirzner; Connie R Bezzina; Carol Ann Remme; Hanno L Tan; Bastiaan J Boukens; Harsha D Devalla; Natalia A Trayanova; Vincent M Christoffels; Phil Barnett; Gerard J J Boink
Published in: European Heart Journal, 2025, ISSN 1522-9645
Publisher: Oxford Academic
DOI: 10.1093/EURHEARTJ/EHAF053

AAV6 vectors provide superior gene transfer compared to AAV9 vectors following intramyocardial administration

Author(s): Jianan Wang; Timo Jonker; Aina Cervera-Barea; Zhenyu Dong; Ruud N. Visser; Evelien E. Birza; Arie R. Boender; Mischa Klerk; Yuting Yang; Joyce Visser; Marlijn S. Jansen; Tom C. Grootswagers; Cindy I. Bart; Saskia C.A. de Jager; Silke Schrödel; Christian Thirion; Osne F. Kirzner; Hanno L. Tan; Antoine A.F. de Vries; Joost P.G. Sluijter; Klaus Neef; Joris R. de Groot; Vincent M. Christoffels; Gerard J.J. Boink
Published in: Molecular Therapy Methods &amp; Clinical Development, 2025, ISSN 2329-0501
Publisher: Cell Press / Elsevier
DOI: 10.1016/J.OMTM.2025.101532