CD22/CD19 dual redirection Dual targeting of CD22 and CD19 with BiTE-secreting and CAR-expressing bispecific T-cells for adoptive Cellular ImmunoTherapy in advanced B-cell Acute Lymphoblastic Leukemia

Project Information

BiTE-CAR

Grant agreement ID: 101100665

DOI

10.3030/101100665

Project closed

EC signature date 5 April 2023

Start date 1 July 2023

End date 31 March 2025

Funded under

• European Research Council (ERC)

Total cost

No data

EU contribution

€ 150 000,00

Coordinated by

FUNDACIO INSTITUT DE RECERCA CONTRA LA LEUCEMIA JOSEP CARRERAS
Spain

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Publications

Peer reviewed articles (2)

Engineered T cells secreting anti-BCMA T cell engagers control multiple myeloma and promote immune memory in vivo.

Author(s): Díez-Alonso, Laura; Falgas, Aïda; Arroyo-Ródenas, Javier; Romencín, Paola A; Martínez, Alba; Gómez-Rosel, Marina; Blanco, Belén; Jiménez-Reinoso, Anaïs; Mayado, Andrea; Pérez-Pons, Alba; Aguilar-Sopeña, Óscar; Ramírez-Fernández, Ángel; Segura-Tudela, Alejandro; Perez-Amill, Lorena; Tapia-Galisteo, Antonio; Domínguez-Alonso, Carmen; Rubio-Pérez, Laura; Jara, Maria; Solé, Francesc; Hangiu, Oana; Almagro, Laura; Albitre, Ángela; Penela, Petronila; Sanz, Laura; Anguita, Eduardo; Valeri, Antonio; García-Ortiz, Almudena; Río, Paula; Juan, Manel; Martínez-López, Joaquín; Roda-Navarro, Pedro; Martín-Antonio, Beatriz; Orfao, Alberto; Menéndez, Pablo; Bueno, Clara; Álvarez-Vallina, Luis; Álvarez-Vallina, Luis
Published in: Science Translational Medicine, Issue Vol. 16, Issue 734, 2024, ISSN 1946-6242
Publisher: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/SCITRANSLMED.ADG7962

CD22 CAR-T cells secreting CD19 T-cell engagers for improved control of B-cell acute lymphoblastic leukemia progression

Author(s): Javier Arroyo-Ródenas, Aida Falgas, Laura Díez-Alonso, Alba Martinez-Moreno, Heleia Roca-Ho, Francisco J. Gil-Etayo, Alba Pérez-Pons, Óscar Aguilar-Sopeña, Miriam Velasco-Sidro, Marina Gómez-Rosel, Beatriz Jiménez-Matías, Guillermo Muñoz-Sánchez, Yedra Pacheco, Clara Bravo-Martín, Ángel Ramírez-Fernández, Anaïs Jiménez-Reinoso, Europa Azucena González-Navarro, Manel Juan, Alberto Orfao, Belén Blanco, Pedro Roda-Navarro, Clara Bueno, Pablo Menéndez, Luis Álvarez-Vallina
Published in: Journal for ImmunoTherapy of Cancer, Issue 13, 2024, ISSN 2051-1426
Publisher: BMJ
DOI: 10.1136/JITC-2024-009048