Project description
Off-the-shelf macrophages for drug safety testing
Macrophages are a key component of the human immune system capable of phagocytosing bacteria and secreting antimicrobial agents. Macrophage-based strategies have recently emerged as a novel and promising immunotherapy against both infections and cancer. Funded by the European Research Council, the iPYRO project proposes to extend macrophage applications to drug safety evaluation. Researchers will develop macrophages from human induced pluripotent stem cells and culture them in a bioreactor, offering a standardised cell product as a drug-screening tool. The product is expected to display superior sensitivity compared to existing solutions and production can be scaled up for high-throughput drug screening.
Objective
The iPYRO proposal is built upon the uniqueness of human induced pluripotent stem cells (iPSC) and recent innovations in the farming of fully defined human macrophages (iMonoMac) using industry compatible bioreactors. Given the growing need for industrial macrophages, iPYRO sets an innovation in the forefront of drug safety evaluations, supplying a unique cell type, which meets the expectations from industry and regulators. The breakthrough innovation of iPYRO will offer a superior, thus highly standardized, economically produced and fully validated off-the-shelf macrophage-based cell product to revolutionize the safety of drugs and beyond. To maximize the outcome, iPYRO will assess the regulatory compliance, while further streamlining the iMonoMac product for the envisioned spinout, establishing a proper freedom-to-operate strategy and a suitable business model. The seminal iMonoMac platform along the unique IPR and established contacts to industrial and regulatory stakeholders will pave the transition from academia to industry, introducing for the very first time an iPSC-cell product for the drug safety market market.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC-POC - HORIZON ERC Proof of Concept Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2022-POC2
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
30625 Hannover
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.