Objective
Symbiotic nitrogen fixation (SNF) carried out by legume nodules is one of the most efficient ways of introducing nitrogen in natural ecosystems and in sustainable agriculture. It relies on the transfer of a relatively large amount of iron from the host plant to the endosymbiotic bacteria colonizing nodule cells, where it will be used as cofactor of many of the enzymes participating in SNF. However, the required steady iron supply for SNF is challenged by its low bioavailability in soil, prevalent in many of the main agricultural areas of the world. This is worsened by the hundreds of ferro-enzymes that compete for iron cofactors within a cell. Due to the relevance of SNF for a more sustainable agriculture, and the importance of ensuring iron supply to achieve this, a substantial effort has been done in understanding how legumes incorporate iron and deliver it to the nodules, and how it is used to synthesize nitrogenase cofactors. However, no information is available on how iron is specifically allocated to the nitrogen-fixing compartments. In this proposal we intend to study the mechanisms enabling targeted iron delivery to nitrogen fixation, particularly those events occurring at the cytosol and at the interface between the two symbionts. To do this, we will identify and characterize the proteins interacting the known symbiosome iron transporters. As a result, we will characterize the iron-interactome of these elements. These findings should not only increase our understanding of iron homeostasis in SNF and, more broadly, in plants, but also lead to dedicated iron delivery pathways for iron-biofortification or to engineer iron-proteins in plants.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology bacteriology
- natural sciences biological sciences ecology ecosystems
- medical and health sciences basic medicine physiology homeostasis
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
- agricultural sciences agriculture, forestry, and fisheries agriculture grains and oilseeds legumes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2022-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
28040 MADRID
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.