Objective Recurrent glioblastoma is an invariably fatal refractory cancer with dismal prognosis. Patients suffer from low quality of life and very burdensome symptoms. This project is proposing an investigator-initiated phase III randomised pragmatic clinical trial. We will assess whether the addition of radiation treatment to lomustine chemotherapy has superior efficacy as compared to lomustine chemotherapy alone for treatment of patients with recurrent glioblastoma. The study will apply minimal patient eligibility criteria, and thus be as close as possible to the routine clinical setting. Cost-effectiveness analysis will be performed to investigate the economic value of adding radiation treatment to lomustine chemotherapy in different countries to support evidence-informed policy decisions. If successful, the outcomes of the project will define a new evidence-based standard of care for recurrent glioblastoma. The proposed research could lead to improved patient survival and quality of life but also improving health system sustainability. This is a multidisciplinary and multistakeholder consortium involving clinical oncologists, radiation oncologists, health economists and patient representatives. The study design was successfully discussed with patients. This action is part of the Cancer Mission cluster of projects on ‘Diagnosis and treatment.” Fields of science medical and health sciencesclinical medicineoncology Keywords Glioblastoma Programme(s) HORIZON.2.1 - Health Main Programme Topic(s) HORIZON-MISS-2022-CANCER-01-03 - Pragmatic clinical trials to optimise treatments for patients with refractory cancers Call for proposal HORIZON-MISS-2022-CANCER-01 See other projects for this call Funding Scheme HORIZON-RIA - HORIZON Research and Innovation Actions Coordinator EUROPEAN ORGANISATION FOR RESEARCH AND TREATMENT OF CANCER AISBL Net EU contribution € 4 764 233,75 Address Avenue e. mounier 83 1200 Brussels / bruxelles Belgium See on map Region Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Participants (3) Sort alphabetically Sort by Net EU contribution Expand all Collapse all MEDIZINISCHE UNIVERSITAET WIEN Austria Net EU contribution € 108 750,00 Address Spitalgasse 23 1090 Wien See on map Region Ostösterreich Wien Wien Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 SYREON KUTATO INTEZET KORLATOLT FELELOSSEGU TARSASAG Hungary Net EU contribution € 518 750,00 Address Mexikoi ut 65/a 1142 Budapest See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Közép-Magyarország Budapest Budapest Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA Italy Net EU contribution € 95 000,00 Address Piazzale aldo moro 5 00185 Roma See on map Region Centro (IT) Lazio Roma Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Partners (1) Sort alphabetically Sort by Net EU contribution Expand all Collapse all BRAINSTRUST United Kingdom Net EU contribution € 0,00 Address 4 yvery court PO31 7QG Cowes See on map Region South East (England) Hampshire and Isle of Wight Isle of Wight Activity type Other Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00
