During the reporting period, significant progress has been made in the project objectives. The core algorithm, termed COLAG (Closed-Loop Autonomous Guidance), has been developed by integrating sequential convex programming for efficient trajectory optimization with a state-of-the-art uncertainty propagation method based on polynomial chaos expansion. This novel two-layer approach has enabled the algorithm to compute fuel-optimal trajectories and satisfy scientific constraints with a high degree of confidence, even under the influence of significant uncertainties in dynamics and state observations. The algorithm has been tested in scenarios, mimicking realistic space missions about minor bodies. Then, the Autonomous Guidance Computer, represented by the deployment of the algorithm on a System-on-a-chip employing both a CPU and a GPU, has prototyped and tested. This validation step ensured that the guidance method executes within the prescribed time frame using onboard computing resources. Comprehensive testing in a simulated close-proximity environment using the RAFFAELLO testbench, a facility able to reproduce the environment close to minor bodies, will be performed in the returning phase to prove the robustness and reliability of the system, paving the way for further integration steps and potential in-orbit demonstrations.