The CASTOR project (Challenging Autonomous Spacecraft through Trajectory Optimization with Robustness) emerges in response to a booming space economy characterized by an increasing number of both commercial near‐Earth and deep-space missions. Traditional ground-based Guidance, Navigation, and Control (GNC) operations are not scalable, particularly for small-scale platforms such as CubeSats, whose low-cost nature and inherent hardware limitations demand a rethinking of on-board autonomy. CASTOR aims to develop a robust, computationally efficient framework for autonomous guidance and control. Its objectives are to design an innovative closed-loop guidance algorithm, capable of re-optimizing trajectories under uncertain dynamic and environmental conditions, deploy it on spacecraft-compatible hardware, and validate the complete system in a laboratory setting simulating close-proximity operations around minor bodies. In doing so, the project addresses critical challenges like reducing human intervention and operational costs while ensuring high-performance autonomous space missions.