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Polypeptide hybrid nanoparticles for the delivery of inhalable drugs

Objective

Infectious respiratory diseases such as COVID or tuberculosis (TB) still have devastating effects on population health. While the development of potent vaccines has drastically reduced infection rates for some diseases, medicinal drugs remain a corner stone of treatment. Respiratory drug delivery via inhalation is considered an ideal way to directly target the site of infection in the lung. However, suitable functional polymeric drug carriers meeting all clinical and pharmaceutical requirements are rare. NanoInhale aims to develop novel polypeptide nanoparticles with mucus penetrating and cell targeting properties suitable for nebuliser-based drug administration to the lower respiratory tract with a project proof-of-concept demonstration for tuberculosis (TB) up to in vitro level. This clinically informed project is placed at the intersection of polymer chemistry, biomaterial science, and drug delivery and further expands into the fields of medical devices and nanomedicine. The project involves academic and clinical collaborators active in the fields of polymer and pharmaceutical science as well as TB Immunology. The applicants expertise in translational polymeric biomaterials in medical applications will be further enhanced by a unique training programme in scientific and complementary skills. NanoInhales impact goes beyond the studied area of TB as this platform technology is envisaged to be exploitable in other respiratory treatments. Project results will be communicated to the scientific community as well as the public to create further awareness of the importance of combating infectious respiratory diseases.

Fields of science (EuroSciVoc)

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Keywords

Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)

Programme(s)

Multi-annual funding programmes that define the EU’s priorities for research and innovation.

Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships

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Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

(opens in new window) HORIZON-MSCA-2022-PF-01

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Coordinator

ROYAL COLLEGE OF SURGEONS IN IRELAND
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 199 694,40
Address
ST STEPHEN'S GREEN 123
2 DUBLIN
Ireland

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Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

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