Objective
Emerging viruses pose a tremendous threat to human health and economy, as dramatically shown by the ongoing COVID-19 pandemic. Most emerging viruses are zoonotic, meaning that they can be transmitted between animal species and humans. Although it was estimated that more than one million viral species exist in the two main reservoirs of zoonotic viruses (mammals and birds), only a few hundred are known to infect humans. This means that the majority of wildlife viral species will likely not cause major outbreaks in the human population, but that many potentially human-infective viruses are lurking in nature. Although large-scale metagenomic studies allowed the identification of thousands of new viral species, functional data, including their ability to infect human cells, are often missing. Previous work has examined the human cell tropism of a fraction of wildlife viruses, but no systematic analysis of the factors involved in viral entry has been undertaken. In this proposal, we will use synthetic biology, experimental virology and viral evolution using a large number of human cell lines to implement a high throughput characterization of wildlife viruses' tropism. We will first test whether wildlife viruses envelopes from diverse viral families can mediate infection of a large panel of human cell lines. Comparing available transcriptomic data of susceptible and non-susceptible cell lines, we will identify novel wildlife viruses host entry factors. Finally, using experimental evolution, we will investigate how viral envelope natural selection and diversification impact the use of these newly identified entry determinants. Overall, this project should improve epidemic preparedness by identifying viral species or variants at higher risk to infect humans, as well as host factors participating to viral entry, which are potential targets for the development of antivirals.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology virology
- medical and health sciences health sciences public health epidemiology pandemics
- natural sciences biological sciences zoology mammalogy
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs antivirals
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2022-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
46010 Valencia
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.