Objective
As the primary risk factor for the onset of cardiovascular disease, hypertension is a major contributor to premature death and disability. High dietary sodium (Na+) consumption is often considered a primary culprit for hypertension, but evidence exists that increasing dietary potassium (K+) consumption may lower blood pressure (BP). However, a number of studies in humans indicate that higher K+ intake is not always beneficial for blood pressure effects that the host lab recently confirmed in rodents. Reducing and maintaining a lower BP based on dietary intervention requires understanding of the long term and/or accumulated effects of the intervention and the underlying molecular basis. This project will increase our understanding of the differential effects of dietary K+ on BP, the role of the kidney and potentially the vasculature. The project objectives are to: 1) determine the optimum dietary K+ intake that reduces and sustains lower BP; 2) identify factors in the kidney that drive K+ sensitivity of BP; 3) assess if sustained high dietary K+ intake changes vascular function; 4) investigate the molecular basis of any vascular remodelling that promotes, or is consequential, to increased BP during prolonged high dietary K+ intake. To address these questions I will apply a broad range of interdisciplinary skills and methods: telemetric monitoring of BP, in vivo assessment of kidney and vascular function in animal models and gene modified mice, RNA sequencing (including single-cell) and bioinformatics, optical clearing and innovative 3D multiplex imaging of tissues. Successful completion of the research in this proposal provides an excellent opportunity to uncover new targets and strategies for the management of hypertension. From a personal perspective it represents a major step towards establishing myself as an independent researcher in the area of renal-vascular crosstalk.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences inorganic chemistry alkali metals
- natural sciences biological sciences genetics RNA
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2022-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
8000 Aarhus C
Denmark
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.