Project description
Brain health monitoring at high altitudes
Cerebral hypoxia has long perplexed medical professionals in critical care medicine. Marked by a shortage of oxygen supply to the brain, the condition can inflict permanent neuronal damage. While cerebral hypoxia affects nearly half of all critically ill patients, studying this condition remains a formidable task. With the support of the Marie Skłodowska-Curie Actions programme, the US-CHIMP project will study this condition at high-altitude environments, where oxygen is scarce. Specifically, it will combine cutting-edge technology, including volumetric ultrasound to measure optic nerve sheath diameter and wave intensity analysis from arteries, as surrogates for intracranial pressure and cerebral oxygen delivery changes. This user-friendly, non-invasive diagnostic tool promises to transform bedside monitoring for various conditions, from intracranial haemorrhage to stroke.
Objective
A lack of oxygen in the human brain (cerebral hypoxia) can result in permanent neuronal damage. Cerebral hypoxia is prevalent in half of all critical ill patients, but poor health impedes research in the intensive care unit. High-altitude exposure (>2500 m) is associated with a lower pressure of oxygen and offers a unique setting to investigate hypoxia-driven changes in otherwise healthy individuals. Unfortunately, at present, non-invasive methods to quantify surrogates of cerebral hypoxia are either laborious and require high-skilled personnel or have large inter-/intra-observer variability and no clear cut-off values. A user-friendly, unambiguous, and accessible diagnostic tool is urgently needed for the monitoring and decision-making in the field and at the beside. US-CHIMP (UltraSound Cerebral Hypoxia Imaging for Monitoring and Prevention) aims to provide a proof-of-concept by combining volumetric US to measure optic nerve sheath diameter as a surrogate of intracranial pressure with wave intensity analysis from the internal carotid and vertebral artery as a surrogate of changes in cerebral oxygen delivery. In three work packages US-CHIMP builds the theoretical groundwork through simulation (WP1/WP2) and the first practical proof-of-concept through translation in an experimental study (WP3) in which human volunteers are exposed to mild hypobaric hypoxia. WP3 is performed in the terraXcube, an extraordinary environmental chamber of the Institute of Mountain Emergency Medicine at Eurac Research. US-CHIMP will provide accurate information about key clinical syndromes. The data is directly relevant to the management of conditions related to high-altitude hypoxia. Besides, many clinical conditions such as intracranial haemorrhage, brain injury and stroke present with elevated intracanal pressures and altered cerebral haemodynamics. Their management will be supported by an accessible and reliable non-invasive bedside monitoring that US-CHIMP aims to provide.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine emergency medicine
- medical and health sciences clinical medicine critical care medicine
- medical and health sciences basic medicine neurology stroke
- natural sciences physical sciences acoustics ultrasound
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
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(opens in new window) HORIZON-MSCA-2022-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
39100 BOLZANO
Italy
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