Objective
Climate change is shaping up to be the greatest existential threat that humanity has ever faced. To combat climate change and the corresponding energy crisis, greenhouse gas emissions must be substantially reduced by 2030 while developing non-fossil future fuel alternatives, such as hydrogen. Hydrogen is highly versatile as it can be used in both fuel cells and electricity production. However, currently >95% of the global hydrogen production is fossil fuel-based and not sustainable. Biotechnological hydrogen production is realized through microorganisms harbouring hydrogenases and represents a promising alternative to expand the proportion of sustainable hydrogen within the global budget. However, the utilization of these enzymes is limited by various mechanisms, including inhibition by oxygen, making biohydrogen in its current state not economically sustainable.
HYDRIDE is an interdisciplinary study aiming to overcome the oxygen sensitivity of [FeFe]- hydrogenases by designing and evolving high-performance hydrogenase enzymes. This will be achieved by 2 major steps: 1) Using sequence data, ancestral enzymatic scaffolds (AEC) of [FeFe]-hydrogenases will be designed and characterized towards their ability to produce hydrogen, their oxygen sensitivity and active site characteristics. AECs have been shown to provide good starting points for laboratory evolution. Thus, these ACEs will be 2) evolved to overcome low hydrogen production under oxygen exposure using a high-throughput selection system.
Consequently, HYDRIDE will tackle one of the major bottlenecks for the utilization of [FeFe]-hydrogenases, paving the way for sustainable and economical biotechnological hydrogen production. While addressing two societal UN sustainability goals, the knowledge gained from this study will substantially advance other scientific fields, aiding e.g. the development and design of artificial catalysts.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences catalysis
- engineering and technology environmental engineering energy and fuels
- natural sciences biological sciences microbiology
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2022-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
751 05 Uppsala
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.