Objective
With increase of global dental implant industry, perimplantitis became an emerging problem worldwide, affecting up to 43% of the placed implants. Periimplantitis is caused by pathogenic microorganisms,that adhere to the implant surface triggering imflammation and bone destruction, eventally leading to implant loss in half of the cases. The overall aim of periimplantitis treatment is re-osteointegration of implant with surrounding bone, that can be achieved only in case of complete control over infection The existing treatment approaches are not able to provide efficient decontamination of the implant surfaces, while effectiveness of the existing local antibiotic delivery systems is questionable. The aim of this project is to develop biomimetic injectable CaP-based pastes with antibacterial and osteogenic properties for periimplantitis treatment. We will utilize biocompatible materials, such as octacalcium phosphate (OCP) and natural hydrogels (hyaluronic acid and functionalized gelatin) that closely resemble to the composition of inorganic and organic components of the bone extracellular matrix. They will serve as versatile platforms for local delivery of antibiotics such as Metronidazole and Doxyciсline or antimicrobial nanoparticles into the peri-implant pockets after mechanical removal of the bacterial biofilm. We hypothesize that these materials will offer control over infection in peri implant area and subsequent cellular functions and may have a great potential for implant re-osteointegration. To date, antibacterial formulations of bone graft materials, targeting peri-implant oral microflora are not available in the market. The obtained innovational products, designed according to the Principles of Good Manufacturing will have optimized composition and handling properties to be used straightforward at the chairside in dental office, without additional invasive surgical manipulations.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology materials engineering composites
- engineering and technology nanotechnology nano-materials
- medical and health sciences medical biotechnology implants
- natural sciences biological sciences microbiology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2022-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1048 RIGA
Latvia
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.