Objective
"The applications of the integrative imaging approach relying on a unique combination of correlative microscopy methods such as secondary ion mass spectroscopy (SIMS) and optical microscopies such as stimulated emission depletion (STED) and electron microscopy (EM) are powered by the development of novel labelling probes for imaging, which play a pivotal role in their progress. There is currently a lack of new probes that can provide a high signal-to-noise ratio and low background in correlative microscopy during the acquisition process by photon counter and mass detector. Therefore, many scientists still cannot apply these advanced microscopy methods to their samples. The unique probe features will result in better contrast and spatio-temporal resolution of the obtained images. Now organic chemists can use the developed organometallic reactions to obtain the target fluorophores for probe construction. This research initiative relying on the tailor-made design and elaborated synthetic strategies will allow obtaining a new class of unique imaging probes with optimized optical properties. The new labelling probes, together with the optimized protocols for sample preparation and image analysis, will help get better image quality, which altogether will provide multi-dimensional information about the studied samples. I will develop new labelling tools for correlative multimodal imaging. Structure-property optimization of such labelling tools requires a tailor-made design of the fluorescent dye, which will not compromise intrinsic photophysical properties responsible for its fluorescence, such as ""photon"" or quantum yield.
I will employ three different biochemical approaches to obtain the labelling probes. The probe design comprising functionalized nanobodies, gold nanoparticles, and fluorophores will be unique. I foresee a broad application of the obtained probes for multimodal bioimaging when they become available to a community of cell biologists and microscopists."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences physical sciences optics microscopy
- engineering and technology nanotechnology nano-materials
- natural sciences physical sciences theoretical physics particle physics photons
- natural sciences physical sciences optics spectroscopy
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2022-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1165 KOBENHAVN
Denmark
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.