Objective
Oceans health is intimately linked to animal and human health in a One Health framework. Marine zoonotic diseases threaten animal and human health and well-being, ecosystem integrity and economic development of marine coastal systems.
Coastal waters, where oysters are produced, are low inerty systems highly sensitive to contaminants, which can also accelerate the emergence of epidemics/epizootics and zoonotic diseases in marine ecosystems. Among them, copper is a widespread pollutant that acts as a major selective pressure influencing microorganism survival and evolution as it can be deadly for many bacteria.
Vibrio aestuarianus subsp. francensis is an emerging pathogen that threatens European aquaculture since 2011. Recent work revealed that this bacterium is an oyster-restricted specialized pathogen. The IHPE laboratory has evidenced that an intimate relationship between virulence and copper resistance conferred by a pathogenicity island could be key in the adaptation of the subspecies to the oyster host.
This proposal aims to evaluate the role of copper resistance in V. aestuarianus francensis adaptation to oyster, and to unveil the copper resistance molecular pathways underlying this key phenotype and infection outcome. Specifically, we will address the following questions:
-Is copper resistance required for V. aestuarianus adaptation and virulence to its host?
-What is the diversity of V. aestuarianus copper resistance mechanisms?
-Does accumulated copper in oyster have an impact in the host-pathogen outcome?
By investigating resistance to copper and virulence as interlinked phenotypes of pathogens and its impact on oyster immunity, we will bring knowledge on the way copper influences the pathogens´dynamics, driving their evolution and specialization in marine ecosystems, but also modulating host-pathogen interactions. Ultimately, the project should help shellfish farmers and policy-makers mitigate the effects of anthropogenic pollution on aquaculture services.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- agricultural sciences agriculture, forestry, and fisheries fisheries
- natural sciences biological sciences microbiology bacteriology
- natural sciences earth and related environmental sciences environmental sciences pollution
- natural sciences biological sciences ecology ecosystems
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2022-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
29280 Plouzane
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.