Objective
Current diagnosis of individuals suffering from disorders on the autism spectrum is based on behavioural and developmental observations, usually in their early life. Even so, there is a significant amount of people having to live with these life-long disorders that remain undetected and no treatment is provided to them. However, it is already established that such disorders are associated with metabolic changes. There is now a growing amount of evidence suggesting that such metabolic
alterations can be detected in samples such as blood or urine taken from children early in their life. These routines however can cause significant discomfort to the child.
The primary aim of the proposal will involve the use of less invasive sampling techniques such as exhaled breath and exhaled breath condensate for the early diagnosis of metabolic hallmarks of autism spectrum disorders. These samples will be analysed using already established chemical analysis techniques for the detection of small metabolic changes in the obtained samples. Tandem mass spectrometry techniques will be used for the unambiguous identification of these metabolites. Data analysis tools such as principal component analysis (PCA) and hierarchical clustering will be used, to associate these metabolic changes with existing medical records obtained from the patients, to establish a potential diagnostic tool.
The potential for the rapid detection of these metabolites will be examined through the integration of novel ambient mass spectrometric ionisation methods such as plasma ionisation. The ability to selectively ionise specific metabolites associated with autism will be investigated with the aim of generating an early prototype of a rapid screening method for routine use. Data generated during the initial stage of the work will be used to create a database that will be used for near real-time
characterisation of the exhaled breath through the analysis of metabolites and volatile organic compounds (VOCs).
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences computer and information sciences data science
- natural sciences computer and information sciences databases
- natural sciences chemical sciences organic chemistry volatile organic compounds
- natural sciences chemical sciences analytical chemistry mass spectrometry
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2022-PF-01
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1678 Nicosia
Cyprus
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.