Objective
Functional neuroimaging is important for understanding brain health, assessing pathologies and guiding therapeutic interventions. Fundamental to neuroimaging is the neurovascular unit (NVU) which relates delivery and consumption of oxygen to neuronal activity. Dysfunction of NVU is associated with pathologies like stroke as well as dyspraxia. Estimating the cerebral metabolic rate of oxygen (CMRO2) that describes NVU activity, requires estimates of oxygen saturation in cerebral blood as well as cerebral blood flow (CBF). Functional magnetic resonance imaging (fMRI), the current gold standard for functional neuroimaging, is expensive, lacks portability and provides only surrogate estimates of CBF. Recent advancements in diffuse optics and functional near-infrared imaging paved the way for non-invasive neuroimaging using diffuse optical techniques. Development of high-density diffuse optical tomography (HDDOT) for imaging oxygen saturation and high-density speckle contrast optical tomography (HDSCOT) for measuring CBF have enabled imaging at spatial resolutions comparable to fMRI. However, combining independently obtained CBF and oxygenation values to compute CMRO2 leads to artifacts and systematic errors. A hybrid imaging modality providing more accurate CMRO2 quantification via co-dependent estimates of oxygen saturation and CBF is needed to tap into potential of optical neuroimaging to paradigms like continuous cerebral monitoring in clinical and naturalistic settings. In this project, we propose development of algorithmic frameworks for such a modality i.e. hybrid HDSCOT/DOT for concurrent estimation of blood flow and oxygenation through (i) development of an inversion algorithm for hybrid imaging, (ii) development of frameworks for selection of optimal acquisition configuration and (iii) numerical and experimental validation of the developed frameworks. This research will closely follow ongoing hardware and system development in the Medical Optics group at ICFO.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pathology
- medical and health sciences basic medicine neurology stroke
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2022-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
08860 Castelldefels
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.