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Applying photon Up-conversion in ROtaxanes for super-Resolution microscopy Analyses

Objective

This multidisciplinary AURORA project focuses on the development of prototype rotaxane (molecular ring-on-thread) structures displaying triplet fusion upconversion photoprocess. Structural design will instill this process via spontaneous excited dye collisions in confined trajectories of the designed interlocked molecules to create a fluorescent state (from two combined low energy photons). Such architectures will help to collect information on molecular photon upconversion and intramolecular diffusion processes through time-resolved spectroscopies. Moreover, it will produce intermittent fluorescence blinking by which detailed analysis will afford a new methodology for super-resolution imaging, namely below the diffraction limit of light. In theory this can provide solutions to some limitations of actual approaches and impact this research field. Fluorescence modulation within these autonomous [2]rotaxanes by triplet fusion will lead to studies down to the single-molecule level (based on Stochastic Optical Reconstruction Microscopy) which will be employed to establish a new localization microscopy method (T2-STORM) and be validated through imaging commercial nanostructured biomacromolecules.
Both leading French research institutes, Institut des Sciences Moleculaires (ISM) and Laboratoire Photonique Numerique et Nanosciences (LP2N) will co-host the AURORA project. The French fellow, specialist in synthetic organic and supramolecular chemistry, will be taught molecular photophysics/photochemistry and super-resolution fluorescence imaging. Additional work packages will guarantee efficient scientific advances, training, career development, management, communication and potentially technology transfer. Association of the fellow and research groups skills at the chemistry-photophysics-imaging interface, available infrastructure and equipment, will participate to both the fellows future independent research career and achieving ambitious AURORA objectives.

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Programme(s)

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Topic(s)

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HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships

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Call for proposal

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(opens in new window) HORIZON-MSCA-2022-PF-01

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Coordinator

UNIVERSITE DE BORDEAUX
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 195 914,88
Address
PLACE PEY BERLAND 35
33000 BORDEAUX
France

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Region
Nouvelle-Aquitaine Aquitaine Gironde
Activity type
Higher or Secondary Education Establishments
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Total cost

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